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Molecular Biology

D-Index
54
Citations
20302
World Ranking
2295
National Ranking
1132

Overview

Dudley W. Lamming is affiliated with the University of Wisconsin-Madison in the United States. Their primary fields of study include Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Physiology, Aging, Molecular Biology, Cell Biology, and Endocrine and Autonomic Systems.

The scientist's research topics cover a broad range of areas related to metabolism, aging, and longevity. Key topics of their work include:

  • Genetics, Aging, and Longevity in Model Organisms
  • Adipose Tissue and Metabolism
  • Diet and metabolism studies
  • Dietary Effects on Health
  • Biochemical effects in animals
  • Muscle metabolism and nutrition
  • Circadian rhythm and melatonin

Lamming has published extensively, with frequent appearances in several scientific venues. Notably, their work is often featured in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Metabolism
  • GeroScience
  • Aging Cell
  • The Journals of Gerontology Series A

Their recent published papers demonstrate an emphasis on the biology of aging, metabolism, and dietary interventions. Some examples include:

  • "Molecular mechanisms of dietary restriction promoting health and longevity," 2021, Nature Reviews Molecular Cell Biology
  • "The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine," 2021, Cell Metabolism
  • "Targeting the biology of aging with mTOR inhibitors," 2023, Nature Aging
  • "Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and life span in mice," 2021, Nature Aging
  • "Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice," 2021, Nature Metabolism

Collaborative efforts are a significant aspect of Lamming's research career, with frequent co-authors including:

  • Cara L. Green
  • Reji Babygirija
  • Michelle M. Sonsalla
  • Chung-Yang Yeh
  • Mariah F. Calubag

Best Publications

  • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

    Konrad T. Howitz;Kevin J. Bitterman;Haim Y. Cohen;Dudley W. Lamming

  • Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

    Dudley W. Lamming;Lan Ye;Pekka Katajisto;Marcus D. Goncalves

  • Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

    Hongying Yang;Tianle Yang;Joseph A. Baur;Evelyn Perez

  • mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

    Ömer H. Yilmaz;Pekka Katajisto;Dudley W. Lamming;Yetis Gültekin;Yetis Gültekin

  • High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

    Semir Beyaz;Semir Beyaz;Miyeko D. Mana;Jatin Roper;Jatin Roper;Dmitriy Kedrin;Dmitriy Kedrin

  • TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

    Stacey Robida-Stubbs;Kira Glover-Cutter;Dudley W. Lamming;Dudley W. Lamming;Masaki Mizunuma;Masaki Mizunuma

  • Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

    Basil P. Hubbard;Ana P. Gomes;Ana P. Gomes;Han Dai;Jun Li

  • The TSC-mTOR pathway regulates macrophage polarization

    Vanessa Byles;Anthony J. Covarrubias;Issam Ben-Sahra;Dudley W. Lamming

  • Rapalogs and mTOR inhibitors as anti-aging therapeutics.

    Dudley W. Lamming;Lan Ye;David M. Sabatini;Joseph A. Baur

  • The mechanistic Target of Rapamycin: The grand conducTOR of metabolism and aging

    Brian K. Kennedy;Dudley W. Lamming

  • Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

    Anthony J Covarrubias;Halil Ibrahim Aksoylar;Jiujiu Yu;Nathaniel W Snyder;Nathaniel W Snyder

  • Molecular mechanisms of dietary restriction promoting health and longevity.

    Cara L Green;Dudley W Lamming;Luigi Fontana

  • Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

    Luigi Fontana;Luigi Fontana;Nicole E. Cummings;Sebastian I. Arriola Apelo;Joshua C. Neuman

  • A Central role for mTOR in lipid homeostasis.

    Dudley W. Lamming;David M. Sabatini

  • Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

    Randy Strong;Richard A Miller;Adam Antebi;Clinton M Astle

  • MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae

    Oliver Medvedik;Dudley W Lamming;Keyman D Kim;David A Sinclair

  • Small molecules that regulate lifespan: evidence for xenohormesis.

    Dudley W. Lamming;Jason G. Wood;David A. Sinclair

  • Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

    B. P. Hubbard;A. P. Gomes;H. Dai;J. Li

  • High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

    Assieh Saadatpour;Sue-Jean Hong;Luca Pinello;Yarden Katz

  • Supplemental Information TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

    Stacey Robida-Stubbs;Kira Glover-Cutter;Dudley W. Lamming;Masaki Mizunuma

Frequent Co-Authors

Joseph A. Baur
Joseph A. Baur University of Pennsylvania
David A. Sinclair
David A. Sinclair Harvard University
Luigi Fontana
Luigi Fontana University of Sydney
Arlan Richardson
Arlan Richardson University of Oklahoma Health Sciences Center
John M. Denu
John M. Denu University of Wisconsin–Madison
Vincent L. Cryns
Vincent L. Cryns Northwestern University
James W. Dennis
James W. Dennis Lunenfeld-Tanenbaum Research Institute
David E. Harrison
David E. Harrison Jackson Laboratory
Brian K. Kennedy
Brian K. Kennedy National University of Singapore

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