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Biology and Biochemistry

D-Index
52
Citations
13512
World Ranking
16504
National Ranking
6832

Overview

Vincent L. Cryns is affiliated with Northwestern University in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with a focus on several interconnected areas of molecular and cellular biology.

The scientist's work is notably concentrated in subfields such as molecular biology, cell biology, oncology, epidemiology, and physiology. These domains reflect the multifaceted nature of their research interests and contributions.

The major topics covered in their publications include:

  • Ubiquitin and proteasome pathways
  • Cancer-related molecular pathways
  • Cellular transport and secretion
  • Protein kinase regulation and GTPase signaling
  • Hippo pathway signaling and YAP/TAZ
  • Autophagy in disease and therapy
  • Metabolism, diabetes, and cancer

Vincent L. Cryns has collaborated frequently with several coauthors, including:

  • Richard A. Anderson
  • Tianmu Wen
  • Mo Chen
  • Noah D. Carrillo
  • Narendra Thapa

The primary venues where Vincent L. Cryns' research has been published are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Nature Cell Biology
  • Breast Cancer Research and Treatment
  • Biomolecules

Significant recent publications include:

  • A p53-phosphoinositide signalosome regulates nuclear AKT activation, 2022, Nature Cell Biology
  • Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence, 2020, Molecular Cell
  • Breast cancer risk for women with diabetes and the impact of metformin: A meta-analysis, 2022, Cancer Medicine
  • The nuclear phosphoinositide response to stress, 2020, Cell Cycle
  • Lysine oxidase exposes a dependency on the thioredoxin antioxidant pathway in triple-negative breast cancer cells, 2020, Breast Cancer Research and Treatment

The research contributions by Vincent L. Cryns reveal an emphasis on molecular signaling pathways involved in cancer and cellular stress responses, as well as the biochemical mechanisms underlying disease states related to metabolism and epigenetics.

Best Publications

  • Proteases to die for

    Vincent Cryns;Junying Yuan

  • Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

    T. Chris Gamblin;Feng Chen;Angara Zambrano;Aida Abraha

  • Catechol Polymers for pH-Responsive, Targeted Drug Delivery to Cancer Cells

    Jing Su;Feng Chen;Vincent L. Cryns;Phillip B. Messersmith

  • The Small Heat Shock Protein αB-Crystallin Negatively Regulates Cytochrome c- and Caspase-8-dependent Activation of Caspase-3 by Inhibiting Its Autoproteolytic Maturation

    Merideth C. Kamradt;Feng Chen;Vincent L. Cryns

  • C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease

    A. Abraha;N. Ghoshal;T.C. Gamblin;V. Cryns

  • Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis.

    Y. Byun;F. Chen;R. Chang;M. Trivedi

  • αB-Crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer

    Jose V. Moyano;Joseph R. Evans;Feng Chen;Meiling Lu

  • Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo.

    Thomas A. Holly;Andjela T Drincic;Youngsup Byun;Sakie Nakamura

  • The Mitochondrial Apoptotic Pathway Is Activated by Serum and Glucose Deprivation in Cardiac Myocytes

    Shani Bialik;Vincent L. Cryns;Andjela Drincic;Setsuya Miyata

  • Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma

    Vincent L. Cryns;Ann Thor;Hong Ji Xu;Shi Xue Hu

  • The Small Heat Shock Protein αB-crystallin Negatively Regulates Apoptosis during Myogenic Differentiation by Inhibiting Caspase-3 Activation

    Merideth C. Kamradt;Feng Chen;Susan Sam;Vincent L. Cryns

  • Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease

    Vincent L. Cryns;Louise Bergeron;Hong Zhu;Honglin Li

  • The Small Heat Shock Protein αB-crystallin Is a Novel Inhibitor of TRAIL-induced Apoptosis That Suppresses the Activation of Caspase-3 *

    Merideth C. Kamradt;Merideth C. Kamradt;Meiling Lu;Michael E. Werner;Toni Kwan

  • Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer's Disease

    Peleg M. Horowitz;Kristina R. Patterson;Angela L. Guillozet-Bongaarts;Matthew R. Reynolds

  • Antitumor activity of peptide amphiphile nanofiber-encapsulated camptothecin

    Stephen Soukasene;Daniel J. Toft;Tyson J. Moyer;Hsuming Lu

  • NanoFlares for the detection, isolation, and culture of live tumor cells from human blood

    Tiffany L. Halo;Kaylin M. McMahon;Nicholas L. Angeloni;Yilin Xu

  • Induction of Cancer Cell Death by Self-assembling Nanostructures Incorporating a Cytotoxic Peptide

    Stephany M. Standley;Daniel J. Toft;Hao Cheng;Stephen Soukasene

  • Minireview: Basal-Like Breast Cancer: From Molecular Profiles to Targeted Therapies

    Daniel J. Toft;Vincent L. Cryns

  • Deconstructing the molecular portrait of basal-like breast cancer

    Fruma Yehiely;Jose V. Moyano;Joseph R. Evans;Torsten O. Nielsen

  • Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.

    Angela L. Guillozet-Bongaarts;Michael E. Cahill;Vincent L. Cryns;Matthew R. Reynolds

Frequent Co-Authors

Samuel I. Stupp
Samuel I. Stupp Northwestern University
Thomas V. O'Halloran
Thomas V. O'Halloran Northwestern University
Torsten O. Nielsen
Torsten O. Nielsen University of British Columbia
Dudley W. Lamming
Dudley W. Lamming University of Wisconsin–Madison
Richard A. Anderson
Richard A. Anderson University of Edinburgh
Kathleen J. Green
Kathleen J. Green Northwestern University
John M. Denu
John M. Denu University of Wisconsin–Madison
Junying Yuan
Junying Yuan Harvard University
Andrew E. Aplin
Andrew E. Aplin Thomas Jefferson University
Kazuhiko Igarashi
Kazuhiko Igarashi Tohoku University

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