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Immunology

D-Index
46
Citations
7050
World Ranking
4639
National Ranking
2088

Overview

C. David Pauza is affiliated with the University of Maryland, Baltimore in the United States. The research encompasses several interconnected fields, primarily within medicine, biochemistry, genetics, and molecular biology with significant work also classified under immunology and microbiology.

The main subfields of study include molecular biology, immunology, oncology, virology, and hematology. Key research topics focus on immune cell function and interaction, CAR-T cell therapy research, HIV research and treatment, monoclonal and polyclonal antibodies research, glycosylation and glycoproteins research, transgenic plants and applications, and CRISPR and genetic engineering.

Selected recent publications by the scientist include:

  • "FcRn-Targeted Mucosal Vaccination against Influenza Virus Infection," 2021, The Journal of Immunology
  • "Advances in cell and gene therapy for HIV disease: it is good to be specific," 2021, Current Opinion in HIV and AIDS
  • "Preclinical Development and Clinical-Scale Manufacturing of HIV Gag-Specific, Lentivirus-Modified CD4 T Cells for HIV Functional Cure," 2020, Molecular Therapy - Methods & Clinical Development
  • "Safety and durability of AGT103-T autologous T cell therapy for HIV infection in a Phase 1 trial," 2022, Frontiers in Medicine
  • "Reducing farnesyl diphosphate synthase levels activates Vγ9Vδ2 T cells and improves tumor suppression in murine xenograft cancer models," 2022, Frontiers in Immunology

Frequent coauthors include Haishan Li, Tyler Lahusen, José Bordón, Lingzhi Xiao, and Nidal Muvarak, indicating collaborations spanning various aspects of immunology and cell therapy research.

Publication venues reflect multidisciplinary interests, such as:

  • The Journal of Immunology
  • Current Opinion in HIV and AIDS
  • Molecular Therapy - Methods & Clinical Development
  • Frontiers in Medicine
  • Frontiers in Immunology

Best Publications

  • Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

    C Terai;R S Kornbluth;C D Pauza;D D Richman

  • Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef.

    David T. Evans;David T. Evans;David H. O'Connor;Peicheng Jing;John L. Dzuris

  • Human γδ T lymphocytes induce robust NK cell mediated antitumor cytotoxicity through CD137 engagement

    Amudhan Maniar;Xiaoyu Zhang;Wei Lin;Brian R. Gastman

  • Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism

    A V Moses;F E Bloom;C D Pauza;J A Nelson

  • Vaccination with Tat toxoid attenuates disease in simian/HIV-challenged macaques

    C. David Pauza;Parul Trivedi;Matthew Wallace;Tracy J.Tracy Ruckwardt

  • Isopentenyl Pyrophosphate–Activated CD56+ γδ T Lymphocytes Display Potent Antitumor Activity toward Human Squamous Cell Carcinoma

    Alan A.Z. Alexander;Amudhan Maniar;Jean Saville Cummings;Andrew M. Hebbeler

  • Human immunodeficiency virus infection of T cells and monocytes proceeds via receptor-mediated endocytosis.

    Unknown

  • Monocytes Treated with Human Immunodeficiency Virus Tat Kill Uninfected CD4+ Cells by a Tumor Necrosis Factor-Related Apoptosis-Induced Ligand-Mediated Mechanism

    Yida Yang;Ilia Tikhonov;Tracy J. Ruckwardt;Mahmoud Djavani

  • Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions

    Lin Li;Hai Shan Li;Hai Shan Li;C David Pauza;Michael Bukrinsky

  • Rhesus Macaques That Become Systemically Infected With Pathogenic SHIV 89.6-PD After Intravenous, Rectal, or Vaginal Inoculation and Fail to Make an Antiviral Antibody Response Rapidly Develop AIDS

    Yichen Lu;C. D. Pauza;Xusheng Lu;D. C. Montefiori

  • A Neonatal Fc Receptor-Targeted Mucosal Vaccine Strategy Effectively Induces HIV-1 Antigen-Specific Immunity to Genital Infection

    Li Lu;Senthilkumar Palaniyandi;Rongyu Zeng;Yu Bai

  • Characterization of Primary Isolate-Like Variants of Simian-Human Immunodeficiency Virus

    John M. Crawford;Patricia L. Earl;Bernard Moss;Keith A. Reimann

  • Definition of Five New Simian Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitopes and Their Restricting Major Histocompatibility Complex Class I Molecules: Evidence for an Influence on Disease Progression

    D. T. Evans;P. Jing;T. M. Allen;D. H. O'Connor

  • Reinfection results in accumulation of unintegrated viral DNA in cytopathic and persistent human immunodeficiency virus type 1 infection of CEM cells.

    Unknown

  • Two bases are deleted from the termini of HIV-1 linear DNA during integrative recombination.

    C. David Pauza

  • Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections.

    M. Wallace;A. M. Scharko;C. D. Pauza;P. Fisch;P. Fisch

  • Gamma Interferon Secretion by Human Vγ2Vδ2 T Cells after Stimulation with Antibody against the T-Cell Receptor plus the Toll-Like Receptor 2 Agonist Pam3Cys

    Carl O. Deetz;Carl O. Deetz;Andrew M. Hebbeler;Andrew M. Hebbeler;Nadia A. Propp;Cristiana Cairo

  • In vitro stimulation with a non-peptidic alkylphosphate expands cells expressing Vγ2-Jγ1.2/Vδ2 T-cell receptors

    Peter S. Evans;Patrick J. Enders;Cheng Cameron Yin;Tracy J. Ruckwardt

  • Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local.

    C. David Pauza;Mei-Ling Liou;Tyler Lahusen;Lingzhi Xiao

  • Whole-body positron emission tomography in patients with HIV-1 infection.

    Alexander M Scharko;Scott B Perlman;Robert W Pyzalski;Franklin M Graziano

  • γδ T Cells in HIV Disease: Past, Present, and Future

    C. David Pauza;Bhawna Poonia;Haishan Li;Cristiana Cairo

  • Early blood profiles of virus infection in a monkey model for Lassa fever.

    Mahmoud M. Djavani;Oswald R. Crasta;Juan Carlos Zapata;Zhangjun Fei

  • Rapamycin reduces CCR5 mRNA levels in macaques: potential applications in HIV-1 prevention and treatment.

    Bruce L Gilliam;Alonso Heredia;Anthony DeVico;Nhut Le

Frequent Co-Authors

Robert R. Redfield
Robert R. Redfield Centers for Disease Control and Prevention
Vittorio Colizzi
Vittorio Colizzi University of Rome Tor Vergata
David C. Montefiori
David C. Montefiori Duke University
Ko Okumura
Ko Okumura Juntendo University
Hideo Yagita
Hideo Yagita Juntendo University
Pierre Hainaut
Pierre Hainaut Grenoble Alpes University
William A. Blattner
William A. Blattner University of Maryland, Baltimore
Renato Franco
Renato Franco University of Campania "Luigi Vanvitelli"
Franco M. Buonaguro
Franco M. Buonaguro MRC Laboratory of Molecular Biology
Daniel N. Streblow
Daniel N. Streblow Oregon Health & Science University

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