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Genetics

D-Index
88
Citations
30573
World Ranking
1161
National Ranking
558

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Austin L. Hughes was affiliated with the University of South Carolina in the United States. Their research primarily focused on medicine, with significant contributions in public health, environmental and occupational health, molecular biology, immunology, pharmacology, and epidemiology.

The scientist published extensively on topics related to malaria research and control, mosquito-borne diseases and control, vaccines and immunoinformatics approaches, traditional and medicinal uses of Annonaceae, the complement system in diseases, vaccine coverage and hesitancy, and alkaloids including their synthesis and pharmacology.

Some of their recent papers included the following:

  • Evidence of Artemisinin-Resistant Malaria in Africa, 2021, New England Journal of Medicine
  • Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda, 2020, Malaria Journal
  • Global Repertoire of Human Antibodies Against Plasmodium falciparum RIFINs, SURFINs, and STEVORs in a Malaria Exposed Population, 2020, Frontiers in Immunology
  • First-in-human randomised trial and follow-up study of Plasmodium falciparum blood-stage malaria vaccine BK-SE36 with CpG-ODN(K3), 2020, Vaccine
  • Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2, 2021, Biochemical and Biophysical Research Communications

The scientist frequently collaborated with other researchers such as Nirianne Palacpac, Takahiro Tougan, Yusuke Hirasawa, Hiroshi Morita, and Alfarius Eko Nugroho.

Their work was published often in venues including Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Journal of Natural Medicines, Frontiers in Immunology, Parasitology International, and Malaria Journal.

Austin L. Hughes was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2009.

Best Publications

  • Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

    Austin L. Hughes;Masatoshi Nei

  • The Evolution of Functionally Novel Proteins after Gene Duplication

    Austin L. Hughes

  • Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.

    Austin L. Hughes;Masatoshi Nei

  • Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia.

    Todd M. Allen;David H. O'Connor;Peicheng Jing;John L. Dzuris

  • A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks

    Greenberg As;Avila D;Hughes M;Hughes A

  • Natural selection at major histocompatibility complex loci of vertebrates

    Austin L. Hughes;Meredith Yeager

  • The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes.

    Ann L Erickson;Yoichi Kimura;Suzu Igarashi;Jennifer Eichelberger

  • Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef.

    David T. Evans;David T. Evans;David H. O'Connor;Peicheng Jing;John L. Dzuris

  • Reversion of CTL escape-variant immunodeficiency viruses in vivo.

    Thomas C Friedrich;Elizabeth J Dodds;Levi J Yant;Lara Vojnov

  • Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection.

    David H. O'Connor;Todd M. Allen;Thorsten U. Vogel;Peicheng Jing

  • Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.

    Amy Weiner;Ann L. Erickson;Joe Kansopon;Kevin Crawford

  • A genome-wide screen identifies a single β-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins

    Yanjing Xiao;Austin L. Hughes;Junko Ando;Yoichi Matsuda

  • Evolution of duplicate genes in a tetraploid animal, Xenopus laevis.

    Marianne K. Hughes;Austin L. Hughes

  • Looking for Darwin in all the wrong places: the misguided quest for positive selection at the nucleotide sequence level

    A L Hughes

  • Positive Darwinian selection promotes charge profile diversity in the antigen-binding cleft of class I major-histocompatibility-complex molecules.

    A L Hughes;T Ota;M Nei

  • Evolution of the major histocompatibility complex: independent origin of nonclassical class I genes in different groups of mammals.

    A L Hughes;M Nei

  • Natural selection on Plasmodium surface proteins

    Marianne K. Hughes;Austin L. Hughes

  • Pattern and timing of gene duplication in animal genomes.

    Robert Friedman;Austin L. Hughes

  • Small genomes for better flyers

    Austin L. Hughes;Marianne K. Hughes

  • New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci

    David I. Watkins;Stephen N. McAdam;Xiaomin Liu;Clarice R. Strang

Frequent Co-Authors

David H. O’Connor
David H. O’Connor University of Wisconsin–Madison
David I. Watkins
David I. Watkins George Washington University
Thomas C. Friedrich
Thomas C. Friedrich University of Wisconsin–Madison
Meredith Yeager
Meredith Yeager Hood College
Alessandro Sette
Alessandro Sette La Jolla Institute For Allergy & Immunology
Roger W. Wiseman
Roger W. Wiseman University of Wisconsin–Madison
John Sidney
John Sidney La Jolla Institute For Allergy & Immunology
Emma Gostick
Emma Gostick Cardiff University
Christopher M. Walker
Christopher M. Walker The Ohio State University
Stephen J. Chanock
Stephen J. Chanock National Institutes of Health

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