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Biology and Biochemistry

D-Index
63
Citations
14676
World Ranking
10192
National Ranking
4451

Overview

Andrew E. Aplin is affiliated with Thomas Jefferson University in the United States. Their research spans multiple fields with a focus on biochemistry, genetics, and molecular biology, as well as medicine. Within these broad areas, their work is concentrated on several subfields including molecular biology, ophthalmology, oncology, immunology, and cell biology.

Their main research topics cover diverse aspects of cancer biology and treatment strategies, particularly in ocular oncology and treatments, melanoma and MAPK pathways, immunotherapy and immune responses, ubiquitin and proteasome pathways, protein degradation and inhibitors, CAR-T cell therapy research, and cancer-related molecular pathways.

Aplin has contributed to notable recent publications including:

  • Melanoma models for the next generation of therapies, 2021, Cancer Cell
  • Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy, 2021, Cancer Discovery
  • Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway, 2022, Journal of Experimental & Clinical Cancer Research
  • Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma, 2022, Nature Communications
  • Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma, 2021, Clinical Cancer Research

They frequently collaborate with several researchers including:

  • Timothy J. Purwin
  • Vivian Chua
  • Claudia Capparelli
  • Takami Sato
  • Manoela Tiago

Aplin has published extensively in well-known scientific venues, with a particular concentration of work appearing in:

  • Cancer Research
  • UNC Libraries
  • Molecular Cancer Research
  • Clinical Cancer Research
  • Molecular Cancer Therapeutics

Best Publications

  • Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins

    A. E. Aplin;A. Howe;S. K. Alahari;R. L. Juliano

  • Integrin signaling and cell growth control.

    Alan Howe;Andrew E. Aplin;Suresh K. Alahari;Rudolph L Juliano

  • Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation.

    Corey Rogers;Dan A. Erkes;Alexandria Nardone;Andrew E. Aplin

  • m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.

    Seungwon Yang;Jiangbo Wei;Yan-Hong Cui;Gayoung Park

  • Cell adhesion molecules, signal transduction and cell growth.

    Andrew E. Aplin;Alan K. Howe;Rl L. Juliano

  • Anchorage-dependent ERK signaling: mechanisms and consequences

    Alan K. Howe;Andrew E. Aplin;Rudolph L Juliano

  • Mutant BRAF and MEK inhibitors regulate the tumor immune microenvironment via pyroptosis

    Dan A. Erkes;Weijia Cai;Ileine M. Sanchez;Timothy J. Purwin

  • Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts

    Tsung H. Lin;Andrew E. Aplin;Yu Shen;Qiming Chen

  • Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1.

    Andrew E. Aplin;Sheryl A. Stewart;Richard K. Assoian;R.L. Juliano

  • Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation.

    Kip M. Connor;Sita Subbaram;Kevin J. Regan;Kristin K. Nelson

  • Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

    Ethan V. Abel;Kevin J. Basile;Curtis H. Kugel;Agnieszka K. Witkiewicz

  • In Vitro Phosphorylation of the Cytoplasmic Domain of the Amyloid Precursor Protein by Glycogen Synthase Kinase‐3β

    Aplin Ae;Gibb Gm;Jacobsen Js;Gallo Jm

  • Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles.

    A. Aplin;T. Jasionowski;D. L. Tuttle;S. E. Lenk

  • Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway

    Andrew E. Aplin;R. L. Juliano

  • Akt3-Mediated Resistance to Apoptosis in B-RAF-Targeted Melanoma Cells

    Yongping Shao;Andrew E. Aplin

  • Melanoma models for the next generation of therapies

    E. Elizabeth Patton;Kristen L. Mueller;David J. Adams;Niroshana Anandasabapathy

  • Integrin regulation of cell signalling and motility.

    R.L. Juliano;P. Reddig;S. Alahari;M. Edin

  • Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling

    Kavita V Bhatt;Laurie S Spofford;Gazelle Aram;Meghan McMullen

  • TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells

    Michele B. Weiss;Ethan V. Abel;Melanie M. Mayberry;Kevin J. Basile

  • Mcl-1 is required for melanoma cell resistance to anoikis.

    Karen Boisvert-Adamo;Whitney Longmate;Ethan V. Abel;Andrew E. Aplin

Frequent Co-Authors

Michael A. Davies
Michael A. Davies The University of Texas MD Anderson Cancer Center
Reinhard Dummer
Reinhard Dummer University of Zurich
Rudy L. Juliano
Rudy L. Juliano University of North Carolina at Chapel Hill
Julio A. Aguirre-Ghiso
Julio A. Aguirre-Ghiso Icahn School of Medicine at Mount Sinai
Marcus Bosenberg
Marcus Bosenberg Yale University
Xiaowei Xu
Xiaowei Xu University of Pennsylvania
Heinz Arnheiter
Heinz Arnheiter National Institutes of Health
Robert N. Kelsh
Robert N. Kelsh University of Bath
Yu-Ying He
Yu-Ying He Duke University
Paolo Fortina
Paolo Fortina Thomas Jefferson University

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