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Thomas V. O'Halloran

Thomas V. O'Halloran

D-Index & Metrics

Chemistry

D-Index
89
Citations
31072
World Ranking
2150
National Ranking
778

Research.com Recognitions

  • 2020 - Fellow, National Academy of Inventors
  • 2013 - Bioinorganic Chemistry Award, Royal Society of Chemistry (UK)
  • 1998 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1991 - Fellow of Alfred P. Sloan Foundation

Overview

Thomas V. O'Halloran is affiliated with Northwestern University in the United States. Their research spans multiple disciplines within biochemistry, genetics, and molecular biology, with a focus that includes molecular biology, nutrition and dietetics, genetics, materials chemistry, and areas related to health, toxicology, and mutagenesis.

The scientist's work frequently addresses topics such as trace elements in health, RNA and protein synthesis mechanisms, bacterial genetics and biotechnology, electrochemical analysis and applications, epigenetics and DNA methylation, cancer-related gene regulation, and reproductive system and pregnancy.

Recent publications by Thomas V. O'Halloran illustrate their focus across molecular and cellular biochemistry as well as metal ion dynamics with titles including:

  • "CueR activates transcription through a DNA distortion mechanism," 2020, Nature Chemical Biology
  • "Metal ion fluxes controlling amphibian fertilization," 2021, Nature Chemistry
  • "The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription," 2020, Nature Communications
  • "Iron drives anabolic metabolism through active histone demethylation and mTORC1," 2023, Nature Cell Biology
  • "Zinc Dynamics during Drosophila Oocyte Maturation and Egg Activation," 2020, iScience

Thomas V. O'Halloran collaborates regularly with several co-authors including Teresa K. Woodruff, Wenan Qiang, Kiwon Ok, Francesca E. Duncan, and Keith W. MacRenaris.

Their work has been published predominantly in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Journal of Biological Chemistry
  • SSRN Electronic Journal
  • The Cambridge Structural Database

Over their career, Thomas V. O'Halloran has received several professional distinctions:

  • Fellow of the National Academy of Inventors (2020)
  • Bioinorganic Chemistry Award, Royal Society of Chemistry (UK) (2013)
  • Fellow of the American Association for the Advancement of Science (AAAS) (1998)
  • Fellow of Alfred P. Sloan Foundation (1991)

Best Publications

  • Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase.

    T. D. Rae;P. J. Schmidt;R. A. Pufahl;V. C. Culotta

  • Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis

    Caryn E. Outten;Thomas V. O'halloran

  • Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors

    Lydia A. Finney;Thomas V. O'Halloran

  • Metallochaperones, an intracellular shuttle service for metal ions.

    Thomas V. O'Halloran;Valeria Cizewski Culotta

  • Metal ion chaperone function of the soluble Cu(I) receptor Atx1.

    R. A. Pufahl;C. P. Singer;K. L. Peariso;S. J. Lin

  • Transition metals in control of gene expression

    Thomas V. O'Halloran

  • Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR

    Anita Changela;Kui Chen;Yi Xue;Jackie Holschen

  • Activation of superoxide dismutases: putting the metal to the pedal.

    Valeria Cizewski Culotta;Mei Yang;Thomas V. O'Halloran

  • The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli.

    F. Wayne Outten;David L. Huffman;Jeremy A. Hale;Thomas V. O'Halloran

  • Function, structure, and mechanism of intracellular copper trafficking proteins.

    David L. Huffman;Thomas V. O'Halloran

  • Emission Ratiometric Imaging of Intracellular Zinc: Design of a Benzoxazole Fluorescent Sensor and Its Application in Two-Photon Microscopy

    Masayasu Taki;Janet L. Wolford;Thomas V. O'Halloran

  • Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

    Han Xiang Deng;Yong Shi;Yoshiaki Furukawa;Hong Zhai

  • A Role for the Saccharomyces cerevisiae ATX1 Gene in Copper Trafficking and Iron Transport

    Su Ju Lin;Robert A. Pufahl;Andrew Dancis;Thomas V. O'Halloran

  • Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins.

    Amy K. Wernimont;David L. Huffman;Audrey L. Lamb;Thomas V. O'Halloran

  • Oxygen-induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS.

    Yoshiaki Furukawa;Andrew S Torres;Thomas V O'Halloran

  • Transcriptional activation of an Escherichia coli copper efflux regulon by the chromosomal MerR homologue, cueR.

    F. Wayne Outten;Caryn E. Outten;Jeremy Hale;Thomas V. O'Halloran

  • Aqueous Coordination Chemistry of Quinoline-Based Fluorescence Probes for the Biological Chemistry of Zinc

    Christoph J. Fahrni;Thomas V. O'Halloran

  • Heterodimeric structure of superoxide dismutase in complex with its metallochaperone

    Audrey L. Lamb;Andrew S. Torres;Thomas V. O'Halloran;Amy C. Rosenzweig

  • The MerR heavy metal receptor mediates positive activation in a topologically novel transcription complex.

    Thomas V. O'Halloran;Betsy Frantz;Myung K. Shin;Diana M. Ralston

  • Metallochaperones and metal-transporting ATPases: a comparative analysis of sequences and structures.

    Fabio Arnesano;Lucia Banci;Ivano Bertini;Simone Ciofi-Baffoni

Frequent Co-Authors

Teresa K. Woodruff
Teresa K. Woodruff Northwestern University
James E. Penner-Hahn
James E. Penner-Hahn University of Michigan–Ann Arbor
SonBinh T. Nguyen
SonBinh T. Nguyen Northwestern University
Amy C. Rosenzweig
Amy C. Rosenzweig Northwestern University
Stefan Vogt
Stefan Vogt Argonne National Laboratory
Valeria C. Culotta
Valeria C. Culotta Johns Hopkins University
Ivano Bertini
Ivano Bertini University of Florence
Leonidas C. Platanias
Leonidas C. Platanias Northwestern University
Lucia Banci
Lucia Banci University of Florence

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