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Molecular Biology

D-Index
64
Citations
22363
World Ranking
1705
National Ranking
860

Research.com Recognitions

  • 2018 - Fellow of the American Academy of Arts and Sciences

Overview

Allan Jacobson is affiliated with the University of Massachusetts Chan Medical School in the United States. Their work spans primarily the fields of biochemistry, genetics, and molecular biology, with a specific focus on molecular biology, genetics, pediatrics, perinatology, child health, neurology, and oncology.

Jacobson's research topics include:

  • RNA and protein synthesis mechanisms
  • RNA research and splicing
  • RNA modifications and cancer
  • Biochemical and molecular research
  • Neonatal health and biochemistry
  • Neurofibromatosis and schwannoma cases
  • Fungal and yeast genetics research

Their most frequent publication venues consist of:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS Genetics
  • Virus Research
  • Nature
  • Nature Communications

Jacobson's recent papers include the following:

  • The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines (2020, Virus Research)
  • Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae (2021, PLoS Genetics)
  • Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination (2020, Cell Reports)
  • Structural mechanism of angiogenin activation by the ribosome (2024, Nature)
  • Eukaryotic mRNA decapping factors: molecular mechanisms and activity (2022, FEBS Journal)

Their frequent co-authors include Kotchaphorn Mangkalaphiban, Feng He, Robin Ganesan, Chan Wu, and Richard Baker, reflecting collaboration across a range of studies mainly in molecular and genetic research areas.

Jacobson was named a Fellow of the American Academy of Arts and Sciences in 2018. This recognition situates them among peers acknowledged for contributions in scientific research.

Best Publications

  • Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents

    Philip L. Ross;Yulin N. Huang;Jason N. Marchese;Brian Williamson

  • PTC124 targets genetic disorders caused by nonsense mutations

    Ellen M. Welch;Elisabeth R. Barton;Jin Zhuo;Yuki Tomizawa

  • INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

    Allan Jacobson;Stuart W. Peltz

  • Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression

    David A Mangus;Matthew C Evans;Allan Jacobson

  • A faux 3'-UTR promotes aberrant termination and triggers nonsense- mediated mRNA decay

    Nadia Amrani;Robin Ganesan;Stephanie Kervestin;David A. Mangus

  • The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

    P Leeds;S W Peltz;A Jacobson;M R Culbertson

  • NMD: a multifaceted response to premature translational termination.

    Stephanie Kervestin;Allan Jacobson

  • Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae

    David Herrick;Roy Parker;Allan Jacobson

  • Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast.

    Feng He;Xiangrui Li;Phyllis Spatrick;Ryan Casillo

  • mRNA poly(A) tail, a 3' enhancer of translational initiation.

    David Munroe;Allan Jacobson

  • mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.

    S W Peltz;A H Brown;A Jacobson

  • Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

    Feng He;Allan Jacobson

  • Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story.

    Feng He;Allan Jacobson

  • Early nonsense: mRNA decay solves a translational problem

    Nadia Amrani;Matthew S. Sachs;Allan Jacobson

  • Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.

    Feng He;Stuart W. Peltz;Janet L. Donahue;Michael Rosbash

  • A single amino acid substitution in yeast eIF-5A results in mRNA stabilization

    Dorit Zuk;Allan Jacobson

  • Tales of poly(A): a review

    David Munroe;Allan Jacobson

  • Ataluren as an Agent for Therapeutic Nonsense Suppression

    Stuart W. Peltz;Manal Morsy;Ellen M. Welch;Allan Jacobson

  • Purification and fractionation of poly(A)+ RNA.

    Allan Jacobson

  • Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.

    Anirban Bhattacharya;Kevin Czaplinski;Panayiota Trifillis;Feng He

Frequent Co-Authors

Matthew S. Sachs
Matthew S. Sachs Texas A&M University
Roy Parker
Roy Parker University of Colorado Boulder
Richard Baker
Richard Baker University of Leicester
Richard A. Firtel
Richard A. Firtel University of California, San Diego
John D. Leszyk
John D. Leszyk University of Massachusetts Chan Medical School
H. Lee Sweeney
H. Lee Sweeney University of Florida
Barry S. Cooperman
Barry S. Cooperman University of Pennsylvania
Jeremy Luban
Jeremy Luban University of Massachusetts Chan Medical School
Elke Mühlberger
Elke Mühlberger Boston University

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