World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
51
Citations
9894
World Ranking
13892
National Ranking
3602

Biology and Biochemistry

D-Index
57
Citations
10799
World Ranking
13925
National Ranking
5885

Overview

P. John Hart is affiliated with The University of Texas Health Science Center at San Antonio in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine, with specific subfields including Molecular Biology, Public Health, Environmental and Occupational Health, Inorganic Chemistry, Parasitology, and Neurology.

Their main research topics cover various aspects of RNA biology and biochemical processes. These topics include:

  • RNA Research and Splicing
  • RNA regulation and disease
  • RNA modifications and cancer
  • Metal-Catalyzed Oxygenation Mechanisms
  • Parasites and Host Interactions
  • Research on Leishmaniasis Studies
  • Biochemical and Molecular Research

Among recent papers authored or co-authored by P. John Hart are:

  • Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? (2020), published in International Journal for Parasitology Drugs and Drug Resistance
  • Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain (2023), published in Journal of Biological Chemistry
  • Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product (2022), published in Biochemistry
  • A pH Switch Controls Zinc Binding in Tomato Copper-Zinc Superoxide Dismutase (2021), published in Biochemistry
  • A pH Switch Controls Zinc Binding in Tomato Copper-Zinc Superoxide Dismutase (2020), published in The FASEB Journal

P. John Hart has frequently published research in the following venues:

  • Biochemistry
  • International Journal for Parasitology Drugs and Drug Resistance
  • Journal of Biological Chemistry
  • The FASEB Journal
  • arXiv (Cornell University)

Frequent co-authors collaborating with P. John Hart include:

  • Alexander B. Taylor
  • S. Holloway
  • Xiaohang Cao
  • Nathaniel E. Clark
  • Adam Katolik

In addition to journal publications, P. John Hart has contributed to book publications, including a work published by Frontiers Media titled Advances in Genetic and Epigenetic Mechanisms of Therapeutic Resistance in Cancer (2023).

Best Publications

  • Misfolded CuZnSOD and amyotrophic lateral sclerosis.

    Joan Selverstone Valentine;P. John Hart

  • Amyloid-like Filaments and Water-filled Nanotubes Formed by SOD1 Mutant Proteins Linked to Familial ALS

    Jennifer Stine Elam;Alexander B Taylor;Richard Strange;Svetlana Antonyuk

  • Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.

    P. John Hart;Shashank Deep;Alexander B. Taylor;Zhanyong Shu

  • Sequence-specific recognition and cooperative dimerization of N-terminal aromatic peptides in aqueous solution by a synthetic host.

    Lisa M Heitmann;Alexander B Taylor;P John Hart;Adam R Urbach

  • A structure-based mechanism for copper-zinc superoxide dismutase.

    P.J Hart;M.M Balbirnie;N.L Ogihara;A.M Nersissian

  • Molecular recognition of insulin by a synthetic receptor.

    Jordan M. Chinai;Alexander B. Taylor;Lisa M. Ryno;Nicholas D. Hargreaves

  • The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis.

    Richard W. Strange;Svetlana Antonyuk;Michael A. Hough;Peter A. Doucette

  • Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.

    Michael A. Hough;J. Günter Grossmann;Svetlana V. Antonyuk;Richard W. Strange

  • Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease.

    Mercedes Prudencio;P. John Hart;P. John Hart;David R. Borchelt;Peter M. Andersen

  • Structure of the Hsp110:Hsc70 Nucleotide Exchange Machine

    Jonathan P. Schuermann;Jianwen Jiang;Jorge Cuellar;Oscar Llorca

  • Shall We Dance? How A Multicopper Oxidase Chooses Its Electron Transfer Partner

    Liliana Quintanar;Christopher Stoj;Alexander B. Taylor;P. John Hart

  • Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

    Celeste M. Karch;Mercedes Prudencio;Duane D. Winkler;P. John Hart

  • The copper-iron connection in biology: structure of the metallo-oxidase Fet3p.

    Alexander B. Taylor;Christopher S. Stoj;Lynn Ziegler;Daniel J. Kosman

  • Chitinases, chitosanases, and lysozymes can be divided into procaryotic and eucaryotic families sharing a conserved core

    Arthur F. Monzingo;Edward M. Marcotte;P. John Hart;Jon D. Robertus

  • A missing link in cupredoxins: crystal structure of cucumber stellacyanin at 1.6 A resolution.

    P. J. Hart;A. M. Nersissian;R. G. Herrmann;R. M. Nalbandyan

  • The refined crystal structure of an endochitinasefrom Hordeum vulgare L. seeds at 1.8 Å resolution

    P. John Hart;Heather D. Pfluger;Arthur F. Monzingo;Thomas Hollis

  • Uclacyanins, stellacyanins, and plantacyanins are distinct subfamilies of phytocyanins: plant-specific mononuclear blue copper proteins.

    A. M. Nersissian;C. Immoos;M. G. Hill;P. J. Hart

  • Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant. Insights into the molecular basis for dimer stability.

    Peter A. Doucette;Lisa J. Whitson;Xiaohang Cao;Virgil Schirf

  • Genetic and Molecular Basis of Drug Resistance and Species-Specific Drug Action in Schistosome Parasites

    Claudia L. L. Valentim;Claudia L. L. Valentim;Donato Cioli;Frédéric D. Chevalier;Xiaohang Cao

  • Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS

    Magdalena I. Ivanova;Stuart A. Sievers;Stuart A. Sievers;Elizabeth L. Guenther;Lisa M. Johnson

Frequent Co-Authors

Joan Selverstone Valentine
Joan Selverstone Valentine University of California, Los Angeles
Borries Demeler
Borries Demeler University of Lethbridge
David R. Borchelt
David R. Borchelt University of Florida
Jon D. Robertus
Jon D. Robertus The University of Texas at Austin
Valeria C. Culotta
Valeria C. Culotta Johns Hopkins University
S. Samar Hasnain
S. Samar Hasnain University of Liverpool
Paul F. Fitzpatrick
Paul F. Fitzpatrick The University of Texas Health Science Center at San Antonio
Philip T. LoVerde
Philip T. LoVerde The University of Texas Health Science Center at San Antonio
Masad J. Damha
Masad J. Damha McGill University
Richard W. Strange
Richard W. Strange University of Essex

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