The scientist’s investigation covers issues in Molecular biology, Transcription factor, Maf Transcription Factors, MafK Transcription Factor and Heme. His research in Molecular biology intersects with topics in Transfection, DNA-binding protein, Promoter, Regulation of gene expression and Transcription. The concepts of his Transcription factor study are interwoven with issues in B cell, Immunoglobulin class switching, Cellular differentiation and Effector.
Kazuhiko Igarashi has included themes like Enhancer and Proto-Oncogene Proteins c-maf in his Maf Transcription Factors study. His studies in MafK Transcription Factor integrate themes in fields like Globin and NF-E2 Transcription Factor. His work on Gene expression as part of general Biochemistry research is frequently linked to Antioxidant Response Elements, bridging the gap between disciplines.
His primary scientific interests are in Molecular biology, Cell biology, Transcription factor, Heme and Biochemistry. In his study, Polymerase is inextricably linked to RNA polymerase, which falls within the broad field of Molecular biology. The Cell biology study combines topics in areas such as Chromatin, Genetics, Histone and Methylation.
His study looks at the intersection of Transcription factor and topics like Cellular differentiation with Cancer research. His work deals with themes such as Repressor and Globin, which intersect with Heme. His MafK Transcription Factor study combines topics in areas such as MafG Transcription Factor and NF-E2 Transcription Factor.
Kazuhiko Igarashi spends much of his time researching Cell biology, Transcription factor, Molecular biology, Chromatin and Cellular differentiation. His Cell biology study integrates concerns from other disciplines, such as HMOX1, Histone, Methylation and Acetylation. His Transcription factor research includes themes of Progenitor cell, Pulmonary alveolar proteinosis and Homeostasis.
His Molecular biology study combines topics from a wide range of disciplines, such as Proteases, Chromatin immunoprecipitation, Regulation of gene expression, Gene silencing and Collagenase. His Chromatin study incorporates themes from IRF4, Psychological repression, Gene expression and Ubiquitin ligase. His Cellular differentiation study deals with the bigger picture of Biochemistry.
His scientific interests lie mostly in Cell biology, Transcription factor, Cellular differentiation, Cancer research and Regulation of gene expression. His Cell biology research incorporates elements of Proteome, Proteomics and Immune system. His work carried out in the field of Transcription factor brings together such families of science as Proteasome inhibitor, Proteasome, Cancer cell, PI3K/AKT/mTOR pathway and Beta-Transducin Repeat-Containing Proteins.
Within one scientific family, Kazuhiko Igarashi focuses on topics pertaining to Effector under Cancer research, and may sometimes address concerns connected to Genetics. Kazuhiko Igarashi has researched Regulation of gene expression in several fields, including MRNA methylation, Methyltransferase, Molecular biology, Untranslated region and MRNA stabilization. His work in Molecular biology addresses subjects such as Hyperoxia, which are connected to disciplines such as Heme and Heme oxygenase.
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AN NRF2/SMALL MAF HETERODIMER MEDIATES THE INDUCTION OF PHASE II DETOXIFYING ENZYME GENES THROUGH ANTIOXIDANT RESPONSE ELEMENTS
Ken Itoh;Tomoki Chiba;Satoru Takahashi;Tetsuro Ishii.
Biochemical and Biophysical Research Communications (1997)
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Ken Itoh;Nobunao Wakabayashi;Yasutake Katoh;Tetsuro Ishii.
Genes & Development (1999)
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
Akira Kobayashi;Moon Il Kang;Hiromi Okawa;Makiko Ohtsuji.
Molecular and Cellular Biology (2004)
A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase
Wilma Ross;Khoosheh K. Gosink;Julia Salomon;Kazuhiko Igarashi.
Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.
Tatsuya Oyake;Ken Itoh;Hozumi Motohashi;Norio Hayashi.
Molecular and Cellular Biology (1996)
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene
Jiying Sun;Jiying Sun;Hideto Hoshino;Hideto Hoshino;Kazuaki Takaku;Osamu Nakajima.
The EMBO Journal (2002)
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1.
Kazuhiro Ogawa;Kazuhiro Ogawa;Jiying Sun;Jiying Sun;Shigeru Taketani;Osamu Nakajima.
The EMBO Journal (2001)
Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins
Kazuhiko Igarashi;Kohsuke Kataokat;Ken Itoh;Norio Hayashi.
CLONING AND CHARACTERIZATION OF A NOVEL ERYTHROID CELL-DERIVED CNC FAMILY TRANSCRIPTION FACTOR HETERODIMERIZING WITH THE SMALL MAF FAMILY PROTEINS
K Itoh;K Igarashi;N Hayashi;M Nishizawa.
Molecular and Cellular Biology (1995)
Bipartite functional map of the E. coli RNA polymerase α subunit: Involvement of the C-terminal region in transcription activation by cAMP-CRP
Kazuhiko Igarashi;Akira Ishihama.
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