D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 67 Citations 18,953 171 World Ranking 1738 National Ranking 89

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Enzyme

The scientist’s investigation covers issues in Molecular biology, Transcription factor, Maf Transcription Factors, MafK Transcription Factor and Heme. His research in Molecular biology intersects with topics in Transfection, DNA-binding protein, Promoter, Regulation of gene expression and Transcription. The concepts of his Transcription factor study are interwoven with issues in B cell, Immunoglobulin class switching, Cellular differentiation and Effector.

Kazuhiko Igarashi has included themes like Enhancer and Proto-Oncogene Proteins c-maf in his Maf Transcription Factors study. His studies in MafK Transcription Factor integrate themes in fields like Globin and NF-E2 Transcription Factor. His work on Gene expression as part of general Biochemistry research is frequently linked to Antioxidant Response Elements, bridging the gap between disciplines.

His most cited work include:

  • AN NRF2/SMALL MAF HETERODIMER MEDIATES THE INDUCTION OF PHASE II DETOXIFYING ENZYME GENES THROUGH ANTIOXIDANT RESPONSE ELEMENTS (2925 citations)
  • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain (2507 citations)
  • Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2 (1487 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Molecular biology, Cell biology, Transcription factor, Heme and Biochemistry. In his study, Polymerase is inextricably linked to RNA polymerase, which falls within the broad field of Molecular biology. The Cell biology study combines topics in areas such as Chromatin, Genetics, Histone and Methylation.

His study looks at the intersection of Transcription factor and topics like Cellular differentiation with Cancer research. His work deals with themes such as Repressor and Globin, which intersect with Heme. His MafK Transcription Factor study combines topics in areas such as MafG Transcription Factor and NF-E2 Transcription Factor.

He most often published in these fields:

  • Molecular biology (39.68%)
  • Cell biology (33.65%)
  • Transcription factor (27.94%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cell biology (33.65%)
  • Transcription factor (27.94%)
  • Molecular biology (39.68%)

In recent papers he was focusing on the following fields of study:

Kazuhiko Igarashi spends much of his time researching Cell biology, Transcription factor, Molecular biology, Chromatin and Cellular differentiation. His Cell biology study integrates concerns from other disciplines, such as HMOX1, Histone, Methylation and Acetylation. His Transcription factor research includes themes of Progenitor cell, Pulmonary alveolar proteinosis and Homeostasis.

His Molecular biology study combines topics from a wide range of disciplines, such as Proteases, Chromatin immunoprecipitation, Regulation of gene expression, Gene silencing and Collagenase. His Chromatin study incorporates themes from IRF4, Psychological repression, Gene expression and Ubiquitin ligase. His Cellular differentiation study deals with the bigger picture of Biochemistry.

Between 2014 and 2021, his most popular works were:

  • The Tohoku Medical Megabank Project: Design and Mission (116 citations)
  • BACH2 regulates CD8 + T cell differentiation by controlling access of AP-1 factors to enhancers (116 citations)
  • BACH2 regulates CD8 + T cell differentiation by controlling access of AP-1 factors to enhancers (116 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Enzyme

His scientific interests lie mostly in Cell biology, Transcription factor, Cellular differentiation, Cancer research and Regulation of gene expression. His Cell biology research incorporates elements of Proteome, Proteomics and Immune system. His work carried out in the field of Transcription factor brings together such families of science as Proteasome inhibitor, Proteasome, Cancer cell, PI3K/AKT/mTOR pathway and Beta-Transducin Repeat-Containing Proteins.

Within one scientific family, Kazuhiko Igarashi focuses on topics pertaining to Effector under Cancer research, and may sometimes address concerns connected to Genetics. Kazuhiko Igarashi has researched Regulation of gene expression in several fields, including MRNA methylation, Methyltransferase, Molecular biology, Untranslated region and MRNA stabilization. His work in Molecular biology addresses subjects such as Hyperoxia, which are connected to disciplines such as Heme and Heme oxygenase.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

AN NRF2/SMALL MAF HETERODIMER MEDIATES THE INDUCTION OF PHASE II DETOXIFYING ENZYME GENES THROUGH ANTIOXIDANT RESPONSE ELEMENTS

Ken Itoh;Tomoki Chiba;Satoru Takahashi;Tetsuro Ishii.
Biochemical and Biophysical Research Communications (1997)

3687 Citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh;Nobunao Wakabayashi;Yasutake Katoh;Tetsuro Ishii.
Genes & Development (1999)

3244 Citations

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi;Moon Il Kang;Hiromi Okawa;Makiko Ohtsuji.
Molecular and Cellular Biology (2004)

1908 Citations

A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase

Wilma Ross;Khoosheh K. Gosink;Julia Salomon;Kazuhiko Igarashi.
Science (1993)

927 Citations

Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.

Tatsuya Oyake;Ken Itoh;Hozumi Motohashi;Norio Hayashi.
Molecular and Cellular Biology (1996)

638 Citations

Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene

Jiying Sun;Jiying Sun;Hideto Hoshino;Hideto Hoshino;Kazuaki Takaku;Osamu Nakajima.
The EMBO Journal (2002)

607 Citations

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1.

Kazuhiro Ogawa;Kazuhiro Ogawa;Jiying Sun;Jiying Sun;Shigeru Taketani;Osamu Nakajima.
The EMBO Journal (2001)

533 Citations

Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins

Kazuhiko Igarashi;Kohsuke Kataokat;Ken Itoh;Norio Hayashi.
Nature (1994)

503 Citations

CLONING AND CHARACTERIZATION OF A NOVEL ERYTHROID CELL-DERIVED CNC FAMILY TRANSCRIPTION FACTOR HETERODIMERIZING WITH THE SMALL MAF FAMILY PROTEINS

K Itoh;K Igarashi;N Hayashi;M Nishizawa.
Molecular and Cellular Biology (1995)

449 Citations

Bipartite functional map of the E. coli RNA polymerase α subunit: Involvement of the C-terminal region in transcription activation by cAMP-CRP

Kazuhiko Igarashi;Akira Ishihama.
Cell (1991)

394 Citations

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