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Kazuhiko Igarashi

Kazuhiko Igarashi

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Genetics and Molecular Biology
Japan
2024

D-Index & Metrics

Molecular Biology

D-Index
88
Citations
36280
World Ranking
775
National Ranking
58

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award

Overview

Kazuhiko Igarashi is affiliated with Tohoku University in Japan and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, with a significant portion of work also intersecting Medicine. Their research output includes 103 publications in Biochemistry, Genetics and Molecular Biology and 62 in Medicine, reflecting a career grounded in molecular and medical sciences.

The subfields in which Igarashi has been most active include Molecular Biology, Immunology, Cancer Research, Pulmonary and Respiratory Medicine, and Cell Biology. Within these areas, the scientist's research addresses several highly specialized topics such as Epigenetics and DNA Methylation, RNA modifications and cancer, Ferroptosis and cancer prognosis, Cancer, Hypoxia, and Metabolism, Cancer, Lipids, and Metabolism, Cancer-related gene regulation, and Immune Cell Function and Interaction.

Recent notable publications by Igarashi include:

  • "Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study" (2020) published in Journal of Epidemiology
  • "BACH1 Promotes Pancreatic Cancer Metastasis by Repressing Epithelial Genes and Enhancing Epithelial-Mesenchymal Transition" (2020) published in Cancer Research
  • "Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal" (2022) published in FEBS Journal
  • "Lipid peroxidation and the subsequent cell death transmitting from ferroptotic cells to neighboring cells" (2021) published in Cell Death and Disease
  • "The transcription factor BACH1 at the crossroads of cancer biology: From epithelial-mesenchymal transition to ferroptosis" (2021) published in Journal of Biological Chemistry

The frequent co-authors associated with Igarashi's research include:

  • Hiroki Shima
  • Mitsuyo Matsumoto
  • Hironari Nishizawa
  • Akihiko Muto
  • Kyoko Ochiai

Publication venues where Igarashi's work has appeared multiple times consist of:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • The Journal of Biochemistry
  • Scientific Reports
  • Blood

Best Publications

  • AN NRF2/SMALL MAF HETERODIMER MEDIATES THE INDUCTION OF PHASE II DETOXIFYING ENZYME GENES THROUGH ANTIOXIDANT RESPONSE ELEMENTS

    Ken Itoh;Tomoki Chiba;Satoru Takahashi;Tetsuro Ishii

  • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

    Ken Itoh;Nobunao Wakabayashi;Yasutake Katoh;Tetsuro Ishii

  • Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

    Akira Kobayashi;Moon Il Kang;Hiromi Okawa;Makiko Ohtsuji

  • A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase

    Wilma Ross;Khoosheh K. Gosink;Julia Salomon;Kazuhiko Igarashi

  • Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene

    Jiying Sun;Jiying Sun;Hideto Hoshino;Hideto Hoshino;Kazuaki Takaku;Osamu Nakajima

  • Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.

    Tatsuya Oyake;Ken Itoh;Hozumi Motohashi;Norio Hayashi

  • Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1.

    Kazuhiro Ogawa;Jiying Sun;Jiying Sun;Shigeru Taketani;Osamu Nakajima

  • Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins

    Kazuhiko Igarashi;Kohsuke Kataokat;Ken Itoh;Norio Hayashi

  • CLONING AND CHARACTERIZATION OF A NOVEL ERYTHROID CELL-DERIVED CNC FAMILY TRANSCRIPTION FACTOR HETERODIMERIZING WITH THE SMALL MAF FAMILY PROTEINS

    K Itoh;K Igarashi;N Hayashi;M Nishizawa

  • BACH2 represses effector programs to stabilize T reg -mediated immune homeostasis

    Rahul Roychoudhuri;Kiyoshi Hirahara;Kiyoshi Hirahara;Kambiz Mousavi;David Clever

  • Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages

    Malay Haldar;Masako Kohyama;Alex Yick Lun So;Wumesh Kc

  • DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics

    Tsuyoshi Ikura;Satoshi Tashiro;Akemi Kakino;Hiroki Shima

  • Bipartite functional map of the E. coli RNA polymerase α subunit: Involvement of the C-terminal region in transcription activation by cAMP-CRP

    Kazuhiko Igarashi;Akira Ishihama

  • Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

    A.Kenneth MacLeod;Michael McMahon;Simon M. Plummer;Larry G. Higgins

  • Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network

    Jiying Sun;Marjorie Brand;Yukari Zenke;Satoshi Tashiro

  • Polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in urban air particulates and their relationship to emission sources in the Pan–Japan Sea countries

    Ning Tang;Tetsuyuki Hattori;Rina Taga;Kazuhiko Igarashi

  • Heme Induces Ubiquitination and Degradation of the Transcription Factor Bach1

    Yukari Zenke-Kawasaki;Yoshihiro Dohi;Yasutake Katoh;Tsuyoshi Ikura

  • Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3.

    Akira Kobayashi;Etsuro Ito;Tsutomu Toki;Keiji Kogame

  • The world according to Maf

    Hozumi Motohashi;Jordan A. Shavit;Kazuhiko Igarashi;Masayuki Yamamoto

  • The transcriptional programme of antibody class switching involves the repressor Bach2

    Akihiko Muto;Satoshi Tashiro;Osamu Nakajima;Hideto Hoshino;Hideto Hoshino

Frequent Co-Authors

Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Etsuro Ito
Etsuro Ito Hirosaki University
Keiko Nakayama
Keiko Nakayama Tohoku University
Hozumi Motohashi
Hozumi Motohashi Tohoku University
Akira Ishihama
Akira Ishihama Hosei University
Tomohisa Takagi
Tomohisa Takagi Kyoto Prefectural University of Medicine
Yuji Naito
Yuji Naito Kyoto Prefectural University of Medicine
Toshikazu Yoshikawa
Toshikazu Yoshikawa Kyoto Prefectural University of Medicine
Akira Kobayashi
Akira Kobayashi Doshisha University
Kengo Kinoshita
Kengo Kinoshita Tohoku University

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