World's Best Scientists 2026 revealed!
Akira Kobayashi

Akira Kobayashi

D-Index & Metrics

Biology and Biochemistry

D-Index
45
Citations
20835
World Ranking
19024
National Ranking
1370

Overview

Akira Kobayashi is affiliated with Doshisha University in Japan and has contributed to multiple research fields, primarily focusing on Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans molecular biology, plant science, surgery, cell biology, and mechanical engineering, reflecting a multidisciplinary approach to scientific inquiry.

Their research addresses various topics, including:

  • Ubiquitin and proteasome pathways
  • Endoplasmic reticulum stress and disease
  • Plant pathogens and fungal diseases
  • Plant physiology and cultivation studies
  • Growth and nutrition in plants
  • Irrigation practices and water management
  • Cancer mechanisms and therapy

Kobayashi has published extensively in multiple journals, with frequent publications appearing in:

  • Plant Production Science
  • arXiv (Cornell University)
  • Scientific Reports
  • Molecular and Cellular Biology
  • iScience

Key papers include:

  • "Roles of NRF3 in the Hallmarks of Cancer: Proteasomal Inactivation of Tumor Suppressors," 2020, published in Cancers
  • "NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression," 2020, published in Molecular and Cellular Biology
  • "NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein," 2020, published in Molecular and Cellular Biology
  • "Influence of forward head posture on muscle activation pattern of the trapezius pars descendens muscle in young adults," 2022, published in Scientific Reports
  • "The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis," 2023, published in Scientific Reports

Kobayashi frequently collaborates with several researchers, including:

  • Tsuyoshi Waku
  • Yukari Kawata
  • Takeo Sakaigaichi
  • Keisuke Suematsu
  • Atsushi Hatanaka

Their contributions notably merge cancer research involving proteasome activity and tumor suppressor mechanisms with studies in plant science and physiological effects. This interdisciplinary work highlights overlap between molecular mechanisms in health and plant biology, exploring cellular pathways involved in disease and plant development.

Best Publications

  • Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

    Akira Kobayashi;Moon Il Kang;Hiromi Okawa;Makiko Ohtsuji

  • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

    Masaaki Komatsu;Hirofumi Kurokawa;Satoshi Waguri;Keiko Taguchi

  • Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

    Masaaki Komatsu;Satoshi Waguri;Masato Koike;Yu shin Sou;Yu shin Sou

  • Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.

    Nobunao Wakabayashi;Albena T. Dinkova-Kostova;W. David Holtzclaw;Moon Il Kang

  • Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1.

    Akira Kobayashi;Moon Il Kang;Yoriko Watai;Kit I. Tong

  • Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer

    Balasundaram Padmanabhan;Kit I. Tong;Tsutomu Ohta;Yoshihiro Nakamura

  • Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

    Tsutomu Ohta;Kumiko Iijima;Mamiko Miyamoto;Izumi Nakahara

  • Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

    Moon Il Kang;Akira Kobayashi;Nobunao Wakabayashi;Sang Geon Kim

  • Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.

    Tae Yamamoto;Takafumi Suzuki;Akira Kobayashi;Junko Wakabayashi

  • Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

    Kit I. Tong;Akira Kobayashi;Fumiki Katsuoka;Masayuki Yamamoto

  • Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1.

    Takumi Satoh;Kunio Kosaka;Ken Itoh;Akira Kobayashi

  • Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response.

    Kit I. Tong;Balasundaram Padmanabhan;Akira Kobayashi;Chengwei Shang

  • Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

    Hiromi Okawa;Hozumi Motohashi;Akira Kobayashi;Hiroyuki Aburatani

  • Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene.

    H. Imataka;K. Sogawa;K.-I. Yasumoto;Y. Kikuchi

  • Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

    Makiko Ohtsuji;Fumiki Katsuoka;Akira Kobayashi;Hiroyuki Aburatani

  • Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3.

    Akira Kobayashi;Etsuro Ito;Tsutomu Toki;Keiji Kogame

  • Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes.

    Akira Kobayashi;Tsutomu Ohta;Masayuki Yamamoto

  • Protein S-guanylation by the biological signal 8-nitroguanosine 3′,5′-cyclic monophosphate

    Tomohiro Sawa;Mohammad Hasan Zaki;Tatsuya Okamoto;Teruo Akuta

  • CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt)

    Akira Kobayashi;Keiko Numayama-Tsuruta;Kazuhiro Sogawa;Yoshiaki Fujii-Kuriyama

  • Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation.

    Kazuhiro Sogawa;Ryosuke Nakano;Akira Kobayashi;Yasuo Kikuchi

Frequent Co-Authors

Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Yoshiaki Fujii-Kuriyama
Yoshiaki Fujii-Kuriyama Tokyo Medical and Dental University
Kazuhiko Igarashi
Kazuhiko Igarashi Tohoku University
Kazuhiro Sogawa
Kazuhiro Sogawa Tohoku University
Ken Itoh
Ken Itoh Hirosaki University
Hozumi Motohashi
Hozumi Motohashi Tohoku University
Tohru Natsume
Tohru Natsume National Institute of Advanced Industrial Science and Technology
Masaru Uchiyama
Masaru Uchiyama Tohoku University
Shun-ichiro Iemura
Shun-ichiro Iemura Fukushima Medical University
Akira Watanabe
Akira Watanabe Kyoto University

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