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Christopher Liddle

Christopher Liddle

D-Index & Metrics

Medicine

D-Index
74
Citations
25690
World Ranking
19312
National Ranking
651

Overview

Christopher Liddle is a researcher affiliated with the University of Sydney in Australia. Their work spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a notable focus on Molecular Biology, Immunology, Genetics, Epidemiology, and Physiology as subfields.

The scientist's research covers several core topics including Adipose Tissue and Metabolism, Liver Disease Diagnosis and Treatment, Immune Cell Function and Interaction, Epigenetics and DNA Methylation, Estrogen and related hormone effects, Pancreatic function and diabetes, as well as Diabetes and associated disorders.

Important recent papers authored or co-authored by Christopher Liddle include:

  • Immune-evasive human islet-like organoids ameliorate diabetes (2020, Nature)
  • Obesity alters pathology and treatment response in inflammatory disease (2022, Nature)
  • Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation (2024, Nature Metabolism)
  • FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes (2021, Cell Reports)
  • Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer (2020, Breast Cancer Research)

Christopher Liddle frequently publishes in a variety of scientific journals. The most common publication venues include:

  • Nature
  • Proceedings of the National Academy of Sciences
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Metabolism

The scientist has collaborated often with several researchers, many of whom have multiple joint publications. The frequent co-authors include:

  • Michael Downes
  • Ronald M. Evans
  • Ruth T. Yu
  • Annette R. Atkins
  • Jacob George

Best Publications

  • PPARγ signaling and metabolism: the good, the bad and the future

    Maryam Ahmadian;Jae Myoung Suh;Nasun Hah;Christopher Liddle

  • NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome

    Shivakumar Chitturi;Shehan Abeygunasekera;Geoffrey C. Farrell;Jane Holmes-Walker

  • Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

    Han Cho;Xuan Zhao;Megumi Hatori;Ruth T. Yu

  • Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

    Mara H. Sherman;Ruth T. Yu;Dannielle D. Engle;Ning Ding

  • Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

    Linda B. Moore;Derek J. Parks;Stacey A. Jones;Randy K. Bledsoe

  • The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module.

    Bryan Goodwin;Ecushla Hodgson;Christopher Liddle

  • Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis

    Martin D. Weltman;Geoffrey C. Farrell;Pauline Hall;Magnus Ingelman‐Sundberg

  • Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

    Sungsoon Fang;Jae Myoung Suh;Shannon M Reilly;Elizabeth Yu

  • A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

    Ning Ding;Ruth T. Yu;Nanthakumar Subramaniam;Mara H. Sherman

  • Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: A manifestation of lipotoxicity?☆

    Shivakumar Chitturi;Geoffrey Farrell;Linda Frost;Adamandia Kriketos

  • Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation

    Weltman;GC Farrell;C Liddle

  • In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.

    Prakash Mistry;Alistair J. Stewart;Wendy Dangerfield;Sade Okiji

  • An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

    Shannon M. Reilly;Shian Huey Chiang;Shian Huey Chiang;Stuart J. Decker;Louise Chang

  • Regulation of Drug Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer

    Edward T. Morgan;Kerry B. Goralski;Micheline Piquette-Miller;Kenneth W. Renton

  • Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis

    Jacob George;Christopher Liddle;Michael Murray;Karen Byth

  • Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor.

    Bryan Goodwin;Ecushla Hodgson;Daniel J. D'Costa;Graham R. Robertson

  • FXR Regulates Intestinal Cancer Stem Cell Proliferation.

    Ting Fu;Sally Coulter;Eiji Yoshihara;Tae Gyu Oh

  • Depletion of fat-resident Treg cells prevents age-associated insulin resistance

    Sagar P. Bapat;Jae Myoung Suh;Jae Myoung Suh;Sungsoon Fang;Sungsoon Fang;Sihao Liu

  • Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes

    N. Henriette Uhlenhaut;Grant D. Barish;Ruth T. Yu;Michael Downes

  • HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity.

    Shivakumar Chitturi;Martin Weltman;Geoffrey C. Farrell;David McDonald

Frequent Co-Authors

Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Michael Downes
Michael Downes Salk Institute for Biological Studies
Jacob George
Jacob George University of Sydney
Ruth T. Yu
Ruth T. Yu Salk Institute for Biological Studies
Geoffrey C. Farrell
Geoffrey C. Farrell Australian National University
David R. Booth
David R. Booth University of Sydney
Elisabetta Bugianesi
Elisabetta Bugianesi University of Turin
James G. Kench
James G. Kench Royal Prince Alfred Hospital
Graeme J. Stewart
Graeme J. Stewart University of Sydney
Alan R. Saltiel
Alan R. Saltiel University of California, San Diego

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