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Biology and Biochemistry

D-Index
89
Citations
45048
World Ranking
2501
National Ranking
1315

Overview

Michael Downes is affiliated with the Salk Institute for Biological Studies in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several specialized subfields including Molecular Biology, Epidemiology, Physiology, Immunology, and Oncology.

Their work covers multiple main research topics such as Liver Disease Diagnosis and Treatment, Adipose Tissue and Metabolism, Epigenetics and DNA Methylation, Pancreatic and Hepatic Oncology Research, Immune Cell Function and Interaction, Fibroblast Growth Factor Research, and Pancreatic function and diabetes.

Downes has published extensively in prominent scientific venues. Frequent publication outlets include:

  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Cell Metabolism
  • Nature Metabolism

Some of the recent publications by Downes include:

  • Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors, 2021, Immunity
  • Global chemical effects of the microbiome include new bile-acid conjugations, 2020, Nature
  • Immune-evasive human islet-like organoids ameliorate diabetes, 2020, Nature
  • A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis, 2020, Cell Metabolism
  • Obesity alters pathology and treatment response in inflammatory disease, 2022, Nature

Collaborations play a significant role in Downes' research output. Frequent coauthors include Ronald M. Evans, Ruth T. Yu, Tae Gyu Oh, Annette R. Atkins, and Christopher Liddle. These collaborations highlight an extensive network particularly within molecular biology and metabolic research communities.

Best Publications

  • The genome sequence of Drosophila melanogaster

    M. D. Adams;S. E. Celniker;R. A. Holt;C. A. Evans

  • Transcriptional co-repressor that interacts with nuclear hormone receptors and uses therefor

    Ronald M. Evans;J. Don Chen

  • PPARγ signaling and metabolism: the good, the bad and the future

    Maryam Ahmadian;Jae Myoung Suh;Nasun Hah;Christopher Liddle

  • Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

    Ryan Lister;Mattia Pelizzola;Yasuyuki S. Kida;R. David Hawkins

  • AMPK and PPARδ Agonists Are Exercise Mimetics

    Vihang A Narkar;Michael Downes;Ruth T. Yu;Emi Embler

  • Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network

    Angie L. Bookout;Yangsik Jeong;Michael Downes;Ruth T. Yu

  • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.

    Takeshi Inagaki;Antonio Moschetta;Youn Kyoung Lee;Li Peng

  • Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

    Han Cho;Xuan Zhao;Megumi Hatori;Ruth T. Yu

  • Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

    Mara H. Sherman;Ruth T. Yu;Dannielle D. Engle;Ning Ding

  • Nuclear Receptor Expression Links the Circadian Clock to Metabolism

    Xiaoyong Yang;Michael Downes;Ruth T. Yu;Angie L. Bookout

  • Humanized xenobiotic response in mice expressing nuclear receptor SXR.

    Wen Xie;Joyce L. Barwick;Michael Downes;Bruce Blumberg

  • A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

    Hung Ying Kao;Peter Ordentlich;Peter Ordentlich;Peter Ordentlich;Naoko Koyano-Nakagawa;Zhenyu Tang;Zhenyu Tang

  • Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

    Sungsoon Fang;Jae Myoung Suh;Shannon M Reilly;Elizabeth Yu

  • A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

    Ning Ding;Ruth T. Yu;Nanthakumar Subramaniam;Mara H. Sherman

  • Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

    Katja A. Lamia;Katja A. Lamia;Stephanie J. Papp;Ruth T. Yu;Grant D. Barish

  • Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis.

    Maria M. Mihaylova;Debbie S. Vasquez;Kim Ravnskjaer;Pierre-Damien Denechaud

  • Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression

    Hung Ying Kao;Michael Downes;Peter Ordentlich;Ronald M. Evans

  • Genome-wide Orchestration of Cardiac Functions by the Orphan Nuclear Receptors ERRα and γ

    Catherine R. Dufour;Brian J. Wilson;Janice M. Huss;Daniel P. Kelly

  • Inflammation-induced IgA + cells dismantle anti-liver cancer immunity

    Shabnam Shalapour;Xue Jia Lin;Xue Jia Lin;Ingmar N. Bastian;John Brain

  • An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

    Shannon M. Reilly;Shian Huey Chiang;Shian Huey Chiang;Stuart J. Decker;Louise Chang

Frequent Co-Authors

Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Ruth T. Yu
Ruth T. Yu Salk Institute for Biological Studies
Christopher Liddle
Christopher Liddle University of Sydney
Alan R. Saltiel
Alan R. Saltiel University of California, San Diego
David A. Brenner
David A. Brenner University of California, San Diego
Rohit Loomba
Rohit Loomba University of California, San Diego
Daniel D. Von Hoff
Daniel D. Von Hoff Translational Genomics Research Institute
David J. Mangelsdorf
David J. Mangelsdorf The University of Texas Southwestern Medical Center
Jerrold M. Olefsky
Jerrold M. Olefsky University of California, San Diego
Pieter C. Dorrestein
Pieter C. Dorrestein University of California, San Diego

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