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Michael Downes

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
45048
World Ranking
2500
National Ranking
1314

Michael Downes publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Michael Downes sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 413 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 848 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 949 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 840 scientists 207–216 publications: 733 scientists 217–226 publications: 708 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 417 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 196 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 59 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 279 publications — 74th percentile

74% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Michael Downes D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Michael Downes sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 316 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 899 scientists 52–53 D-Index: 1,025 scientists 54–55 D-Index: 1,149 scientists 56–57 D-Index: 1,235 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,162 scientists 62–63 D-Index: 1,130 scientists 64–65 D-Index: 1,031 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 714 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 71 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 89 D-Index — 87th percentile

87% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Michael Downes is affiliated with the Salk Institute for Biological Studies in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several specialized subfields including Molecular Biology, Epidemiology, Physiology, Immunology, and Oncology.

Their work covers multiple main research topics such as Liver Disease Diagnosis and Treatment, Adipose Tissue and Metabolism, Epigenetics and DNA Methylation, Pancreatic and Hepatic Oncology Research, Immune Cell Function and Interaction, Fibroblast Growth Factor Research, and Pancreatic function and diabetes.

Downes has published extensively in prominent scientific venues. Frequent publication outlets include:

  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Cell Metabolism
  • Nature Metabolism

Some of the recent publications by Downes include:

  • Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors, 2021, Immunity
  • Global chemical effects of the microbiome include new bile-acid conjugations, 2020, Nature
  • Immune-evasive human islet-like organoids ameliorate diabetes, 2020, Nature
  • A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis, 2020, Cell Metabolism
  • Obesity alters pathology and treatment response in inflammatory disease, 2022, Nature

Collaborations play a significant role in Downes' research output. Frequent coauthors include Ronald M. Evans, Ruth T. Yu, Tae Gyu Oh, Annette R. Atkins, and Christopher Liddle. These collaborations highlight an extensive network particularly within molecular biology and metabolic research communities.

Best Publications

  • The genome sequence of Drosophila melanogaster

    M. D. Adams;S. E. Celniker;R. A. Holt;C. A. Evans

  • Transcriptional co-repressor that interacts with nuclear hormone receptors and uses therefor

    Ronald M. Evans;J. Don Chen

  • PPARγ signaling and metabolism: the good, the bad and the future

    Maryam Ahmadian;Jae Myoung Suh;Nasun Hah;Christopher Liddle

  • Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

    Ryan Lister;Mattia Pelizzola;Yasuyuki S. Kida;R. David Hawkins

  • AMPK and PPARδ Agonists Are Exercise Mimetics

    Vihang A Narkar;Michael Downes;Ruth T. Yu;Emi Embler

  • Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network

    Angie L. Bookout;Yangsik Jeong;Michael Downes;Ruth T. Yu

  • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.

    Takeshi Inagaki;Antonio Moschetta;Youn Kyoung Lee;Li Peng

  • Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

    Han Cho;Xuan Zhao;Megumi Hatori;Ruth T. Yu

  • Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

    Mara H. Sherman;Ruth T. Yu;Dannielle D. Engle;Ning Ding

  • Nuclear Receptor Expression Links the Circadian Clock to Metabolism

    Xiaoyong Yang;Michael Downes;Ruth T. Yu;Angie L. Bookout

  • Humanized xenobiotic response in mice expressing nuclear receptor SXR.

    Wen Xie;Joyce L. Barwick;Michael Downes;Bruce Blumberg

  • A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

    Hung Ying Kao;Peter Ordentlich;Peter Ordentlich;Peter Ordentlich;Naoko Koyano-Nakagawa;Zhenyu Tang;Zhenyu Tang

  • Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

    Sungsoon Fang;Jae Myoung Suh;Shannon M Reilly;Elizabeth Yu

  • A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

    Ning Ding;Ruth T. Yu;Nanthakumar Subramaniam;Mara H. Sherman

  • Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

    Katja A. Lamia;Katja A. Lamia;Stephanie J. Papp;Ruth T. Yu;Grant D. Barish

  • Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis.

    Maria M. Mihaylova;Debbie S. Vasquez;Kim Ravnskjaer;Pierre-Damien Denechaud

  • Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression

    Hung Ying Kao;Michael Downes;Peter Ordentlich;Ronald M. Evans

  • Genome-wide Orchestration of Cardiac Functions by the Orphan Nuclear Receptors ERRα and γ

    Catherine R. Dufour;Brian J. Wilson;Janice M. Huss;Daniel P. Kelly

  • Inflammation-induced IgA + cells dismantle anti-liver cancer immunity

    Shabnam Shalapour;Xue Jia Lin;Xue Jia Lin;Ingmar N. Bastian;John Brain

  • An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

    Shannon M. Reilly;Shian Huey Chiang;Shian Huey Chiang;Stuart J. Decker;Louise Chang

Frequent Co-Authors

Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Ruth T. Yu
Ruth T. Yu Salk Institute for Biological Studies
Christopher Liddle
Christopher Liddle University of Sydney
Alan R. Saltiel
Alan R. Saltiel University of California, San Diego
David A. Brenner
David A. Brenner University of California, San Diego
Rohit Loomba
Rohit Loomba University of California, San Diego
Daniel D. Von Hoff
Daniel D. Von Hoff Translational Genomics Research Institute
David J. Mangelsdorf
David J. Mangelsdorf The University of Texas Southwestern Medical Center
Jerrold M. Olefsky
Jerrold M. Olefsky University of California, San Diego
Pieter C. Dorrestein
Pieter C. Dorrestein University of California, San Diego

External Links

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Best Scientists Citing Michael Downes

Ronald M. Evans

Ronald M. Evans

Salk Institute for Biological Studies

Publications: 85

Frank J. Gonzalez

Frank J. Gonzalez

National Institutes of Health

Publications: 78

Wen Xie

Wen Xie

University of Pittsburgh

Publications: 73

Bart Staels

Bart Staels

University of Lille

Publications: 72

Bernd Schnabl

Bernd Schnabl

University of California, San Diego

Publications: 67

Johan Auwerx

Johan Auwerx

École Polytechnique Fédérale de Lausanne

Publications: 66

Mitchell A. Lazar

Mitchell A. Lazar

University of Pennsylvania

Publications: 64

Walter Wahli

Walter Wahli

University of Lausanne

Publications: 64

Michael Trauner

Michael Trauner

Medical University of Vienna

Publications: 59

Carsten Carlberg

Carsten Carlberg

University of Eastern Finland

Publications: 46

Stefano Fiorucci

Stefano Fiorucci

University of Perugia

Publications: 42

David W. Ray

David W. Ray

University of Oxford

Publications: 42

Vincent Giguère

Vincent Giguère

McGill University

Publications: 39

Gerald M. Rubin

Gerald M. Rubin

Howard Hughes Medical Institute

Publications: 38

Benoit Viollet

Benoit Viollet

Institut Cochin

Publications: 37

Susan E. Celniker

Susan E. Celniker

Lawrence Berkeley National Laboratory

Publications: 35

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