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Best Scientists
2025

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Best Scientists

D-Index
168
Citations
86042
World Ranking
952
National Ranking
564

Medicine

D-Index
172
Citations
91415
World Ranking
497
National Ranking
297

Research.com Recognitions

  • 2025 - Research.com Best Scientists Award

Overview

David A. Brenner is affiliated with the University of California, San Diego in the United States. Their research spans multiple fields with a focus primarily on medicine and biochemistry, genetics, and molecular biology. Within these broader areas, they have contributed substantially to subfields including epidemiology, hepatology, molecular biology, surgery, and cell biology.

The scholar's work covers a variety of topics related to liver disease and physiology, as well as associated conditions and biological mechanisms. Key research themes include liver disease diagnosis and treatment, liver physiology and pathology, endoplasmic reticulum stress and disease, liver disease and transplantation, alcohol consumption and health effects, pancreatic function and diabetes, and gut microbiota and health.

Recent published papers by David A. Brenner include:

  • Molecular and cellular mechanisms of liver fibrosis and its regression, 2020, Nature Reviews Gastroenterology & Hepatology
  • Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission, 2022, Nature
  • Mechanisms of liver fibrosis and its role in liver cancer, 2020, Experimental Biology and Medicine
  • A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis, 2020, Cell Metabolism
  • Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome, 2022, Nature

Frequent coauthors who have collaborated extensively with this researcher include Tatiana Kisseleva, Sara Brin Rosenthal, Debanjan Dhar, Jacopo Baglieri, and Michael Karin.

The researcher has published extensively in various venues. The most frequent publication venues include:

  • UNC Libraries
  • Gastroenterology
  • Nature
  • PLoS ONE
  • Cell Metabolism

Best Publications

  • Erratum: Liver fibrosis (Journal of Clinical Investigation (2005) 115 (209-218) DOI:10.1172/JCI200524282)

    Ramón Bataller;David A. Brenner

  • TLR4 enhances TGF-beta signaling and hepatic fibrosis.

    Ekihiro Seki;Samuele De Minicis;Samuele De Minicis;Christoph H Österreicher;Christoph H Österreicher;Johannes Kluwe

  • The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.

    John J. Lemasters;Anna Liisa Nieminen;Ting Qian;Lawrence C. Trost;Lawrence C. Trost

  • Molecular and cellular mechanisms of liver fibrosis and its regression.

    Tatiana Kisseleva;David Brenner

  • Liver inflammation and fibrosis

    Yukinori Koyama;David A. Brenner

  • The gut–liver axis and the intersection with the microbiome

    Anupriya Tripathi;Anupriya Tripathi;Justine Debelius;David A. Brenner;Michael Karin

  • Interactions between the intestinal microbiome and liver diseases.

    Bernd Schnabl;David A. Brenner

  • Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.

    C Jobin;C A Bradham;M P Russo;B Juma

  • Prolonged activation of jun and collagenase genes by tumour necrosis factor- α

    David A. Brenner;Maureen O'Hara;Peter Angel;Mario Chojkier

  • Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease

    Rohit Loomba;Victor Seguritan;Weizhong Li;Tao Long

  • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney.

    Shuei Liong Lin;Tatiana Kisseleva;David A. Brenner;Jeremy S. Duffield

  • Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways

    Robert F. Schwabe;David A. Brenner

  • Enteric dysbiosis associated with a mouse model of alcoholic liver disease

    Arthur W. Yan;Derrick E. Fouts;Johannes Brandl;Johannes Brandl;Peter Stärkel

  • Toll-Like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells

    Yong-Han Paik;Yong-Han Paik;Robert F. Schwabe;Ramón Bataller;Maria P. Russo

  • Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

    Tatiana Kisseleva;Min Cong;YongHan Paik;David Scholten

  • Toll-like receptors and adaptor molecules in liver disease: update.

    Ekihiro Seki;David A. Brenner

  • Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

    Kouichi Miura;Kouichi Miura;Yuzo Kodama;Sayaka Inokuchi;Bernd Schnabl

  • Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

    Sungsoon Fang;Jae Myoung Suh;Shannon M Reilly;Elizabeth Yu

  • NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis

    Ramón Bataller;Robert F. Schwabe;Youkyung H. Choi;Liu Yang

  • Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients with Biopsy-proven Nonalcoholic Fatty Liver Disease

    Charlie C. Park;Phirum Nguyen;Carolyn Hernandez;Ricki Bettencourt

Frequent Co-Authors

Tatiana Kisseleva
Tatiana Kisseleva University of California, San Diego
Bernd Schnabl
Bernd Schnabl University of California, San Diego
Rohit Loomba
Rohit Loomba University of California, San Diego
Robert F. Schwabe
Robert F. Schwabe Columbia University
Claude B. Sirlin
Claude B. Sirlin University of California, San Diego
Ramon Bataller
Ramon Bataller University of Pittsburgh
John J. Lemasters
John J. Lemasters Medical University of South Carolina
Ronald G. Thurman
Ronald G. Thurman University of North Carolina at Chapel Hill
Albert C. Ludolph
Albert C. Ludolph University of Ulm
Michael Karin
Michael Karin University of California, San Diego

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