World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
88
Citations
23855
World Ranking
2331
National Ranking
833

Biology and Biochemistry

D-Index
95
Citations
29390
World Ranking
1927
National Ranking
1056

Overview

Ronen Marmorstein is affiliated with the University of Pennsylvania in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans 125 publications in the broader area of Biochemistry, Genetics and Molecular Biology, with significant focus on Molecular Biology, Oncology, and Cancer Research.

Their recent research output includes papers on various molecular processes and disease mechanisms, covering topics such as signaling pathways, peptidase inhibition, and protein folding. Notable recent papers include:

  • The MEK/ERK Network as a Therapeutic Target in Human Cancer, 2020, Molecular Cancer Research
  • Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation, 2020, Trends in Biochemical Sciences
  • DAXX Represents a New Type of Protein-Folding Enabler, 2021, Nature
  • The Copper Chaperone CCS Facilitates Copper Binding to MEK1/2 to Promote Kinase Activation, 2021, Journal of Biological Chemistry
  • Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers, 2021, Cancer Research

The scientist's research topics include but are not limited to:

  • Peptidase Inhibition and Analysis
  • Signaling Pathways in Disease
  • Ubiquitin and Proteasome Pathways
  • RNA Modifications and Cancer
  • Melanoma and MAPK Pathways
  • Cancer, Lipids, and Metabolism
  • Microbial Natural Products and Biosynthesis

Frequent publication venues for Ronen Marmorstein include journals such as:

  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • The FASEB Journal
  • Cancer Research

Collaborations are a significant aspect of their research, with recurrent coauthors being Kollin Schultz, Xuepeng Wei, Nancy Meyer, Leah Gottlieb, and Sunbin Deng.

This body of work reflects a focus on molecular mechanisms underlying disease processes, particularly cancer, and the biochemical pathways and molecular biology techniques related to therapeutic targets and molecular function modulation.

Best Publications

  • Crystal structure of trp repressor/operator complex at atomic resolution.

    Otwinowski Z;Schevitz Rw;Zhang Rg;Lawson Cl

  • Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

    Nitai C. Hait;Jeremy Allegood;Michael Maceyka;Graham M. Strub

  • p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage.

    Lin Liu;Daniel M. Scolnick;Raymond C. Trievel;Hong Bing Zhang

  • Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

    Stephen M. Sykes;Hestia S. Mellert;Hestia S. Mellert;Marc A. Holbert;Keqin Li

  • DNA recognition by GAL4: structure of a protein-DNA complex

    Ronen Marmorstein;Michael Carey;Michael Carey;Mark Ptashne;Stephen C. Harrison;Stephen C. Harrison

  • Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

    Loren M. Lasko;Clarissa G. Jakob;Rohinton P. Edalji;Wei Qiu

  • Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14

    Wan Sheng Lo;Raymond C. Trievel;Jeannie R. Rojas;Laura Duggan

  • Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.

    Erin M. Bowers;Gai Yan;Chandrani Mukherjee;Andrew Orry

  • Autophagy mediates degradation of nuclear lamina

    Zhixun Dou;Caiyue Xu;Greg Donahue;Takeshi Shimi

  • Writers and Readers of Histone Acetylation: Structure, Mechanism, and Inhibition

    Ronen Marmorstein;Ming-Ming Zhou

  • Histone acetyltransferases: function, structure, and catalysis

    Ronen Marmorstein;Sharon Y Roth

  • The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

    Xin Liu;Ling Wang;Kehao Zhao;Kehao Zhao;Paul R. Thompson;Paul R. Thompson

  • Histone modifying enzymes: structures, mechanisms, and specificities.

    Ronen Marmorstein;Raymond C. Trievel

  • Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design

    S C Hodawadekar;R Marmorstein

  • Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor.

    Xin Liu;Xin Liu;Adrienne Clements;Adrienne Clements;Kehao Zhao;Ronen Marmorstein;Ronen Marmorstein

  • Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide.

    Jeannie R. Rojas;Raymond C. Trievel;Raymond C. Trievel;Jianxin Zhou;Yi Mo

  • Structural basis for sirtuin function: what we know and what we don't.

    Brandi D. Sanders;Brittany Jackson;Ronen Marmorstein

  • A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions

    Chunling Yi;Scott Troutman;Daniela Fera;Daniela Fera;Anat Stemmer-Rachamimov

  • Protein modules that manipulate histone tails for chromatin regulation

    Ronen Marmorstein

  • Catalytic Mechanism and Function of Invariant Glutamic Acid 173 from the Histone Acetyltransferase GCN5 Transcriptional Coactivator

    Kirk G. Tanner;Raymond C. Trievel;Raymond C. Trievel;Min-Hao Kuo;Robyn M. Howard

Frequent Co-Authors

Shelley L. Berger
Shelley L. Berger University of Pennsylvania
Thomas Arnesen
Thomas Arnesen University of Bergen
Philip A. Cole
Philip A. Cole Brigham and Women's Hospital
Xin Liu
Xin Liu Chinese Academy of Sciences
Cheng Luo
Cheng Luo Chinese Academy of Sciences
Eric Meggers
Eric Meggers Philipp University of Marburg
David W. Speicher
David W. Speicher The Wistar Institute
Peter D. Adams
Peter D. Adams Sanford Burnham Prebys Medical Discovery Institute
Pierre Thibault
Pierre Thibault University of Montreal
Stephen C. Harrison
Stephen C. Harrison Harvard University

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