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Biology and Biochemistry

D-Index
71
Citations
18821
World Ranking
6615
National Ranking
3081

Overview

Kazuaki Takabe is a researcher affiliated with the Roswell Park Cancer Institute in the United States. Their work spans primarily the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on Oncology, Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine, and Immunology.

Their research addresses several key topics including:

  • Ferroptosis and cancer prognosis
  • Cancer Immunotherapy and Biomarkers
  • Cancer Genomics and Diagnostics
  • Cancer Cells and Metastasis
  • Cancer-related molecular mechanisms research
  • Breast Cancer Treatment Studies
  • RNA modifications and cancer

Kazuaki Takabe has contributed to numerous scientific publications, with notable recent papers including:

  • "M1 Macrophage and M1/M2 ratio defined by transcriptomic signatures resemble only part of their conventional clinical characteristics in breast cancer," 2020, Scientific Reports
  • "CD8 T Cell Score as a Prognostic Biomarker for Triple Negative Breast Cancer," 2020, International Journal of Molecular Sciences
  • "G2M Cell Cycle Pathway Score as a Prognostic Biomarker of Metastasis in Estrogen Receptor (ER)-Positive Breast Cancer," 2020, International Journal of Molecular Sciences
  • "Neoadjuvant Chemotherapy for Breast Cancer: Past, Present, and Future," 2020, Breast Cancer Basic and Clinical Research
  • "The E2F Pathway Score as a Predictive Biomarker of Response to Neoadjuvant Therapy in ER+/HER2− Breast Cancer," 2020, Cells

Frequent collaborators in their work include:

  • Masanori Oshi
  • Yoshihisa Tokumaru
  • Itaru Endo
  • Li Yan
  • Takashi Ishikawa

The primary publication venues for their research are:

  • Cancer Research
  • World Journal of Oncology
  • Cancers
  • Annals of Surgical Oncology
  • Journal of Clinical Oncology

Best Publications

  • “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

    Kazuaki Takabe;Steven W. Paugh;Sheldon Milstien;Sarah Spiegel

  • Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.

    Yi Zhou Jiang;Ding Ma;Chen Suo;Jinxiu Shi

  • Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

    Jie Liang;Masayuki Nagahashi;Eugene Y. Kim;Kuzhuvelil B. Harikumar

  • Cancer cachexia, mechanism and treatment.

    Tomoyoshi Aoyagi;Krista P Terracina;Ali Raza;Hisahiro Matsubara

  • Targeting SphK1 as a new strategy against cancer.

    Dai Shida;Kazuaki Takabe;Dmitri Kapitonov;Sheldon Milstien

  • Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.

    Masayuki Nagahashi;Subramaniam Ramachandran;Eugene Y. Kim;Jeremy C. Allegood

  • Estradiol Induces Export of Sphingosine 1-Phosphate from Breast Cancer Cells via ABCC1 and ABCG2

    Kazuaki Takabe;Roger H. Kim;Jeremy C. Allegood;Poulami Mitra

  • Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes.

    Elaine Studer;Xiqiao Zhou;Renping Zhao;Yun Wang

  • Sustained correction of bleeding disorder in hemophilia B mice by gene therapy.

    Lili Wang;Kazuaki Takabe;Scott M. Bidlingmaier;Charles R. Ill

  • Export and functions of sphingosine-1-phosphate.

    Roger H. Kim;Kazuaki Takabe;Sheldon Milstien;Sarah Spiegel

  • Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis

    Masayuki Nagahashi;Akimitsu Yamada;Akimitsu Yamada;Eriko Katsuta;Eriko Katsuta;Tomoyoshi Aoyagi

  • Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential.

    Masayo Aoki;Hiroaki Aoki;Rajesh Ramanathan;Nitai C. Hait

  • The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice.

    Yongqing Wang;Hiroaki Aoki;Jing Yang;Kesong Peng

  • Conjugated bile acid–activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

    Masayuki Nagahashi;Kazuaki Takabe;Runping Liu;Runping Liu;Kesong Peng

  • Export of sphingosine-1-phosphate and cancer progression.

    Kazuaki Takabe;Sarah Spiegel

  • Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

    Masayuki Nagahashi;Eugene Y. Kim;Akimitsu Yamada;Subramaniam Ramachandran

  • Cross-talk between LPA1 and Epidermal Growth Factor Receptors Mediates Up-regulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion

    Dai Shida;Xianjun Fang;Tomasz Kordula;Kazuaki Takabe

  • High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival

    Akimitsu Yamada;Takashi Ishikawa;Ikuko Ota;Mariko Kimura

  • Methods of esophagogastric anastomoses following esophagectomy for cancer: A systematic review.

    Roger H. Kim;Kazuaki Takabe

  • CD8 T Cell Score as a Prognostic Biomarker for Triple Negative Breast Cancer.

    Masanori Oshi;Masanori Oshi;Mariko Asaoka;Mariko Asaoka;Yoshihisa Tokumaru;Yoshihisa Tokumaru;Li Yan

Frequent Co-Authors

Li Yan
Li Yan Roswell Park Comprehensive Cancer Center
Sarah Spiegel
Sarah Spiegel Virginia Commonwealth University
Itaru Endo
Itaru Endo Yokohama City University
Sheldon Milstien
Sheldon Milstien Virginia Commonwealth University
Jeremy C. Allegood
Jeremy C. Allegood Virginia Commonwealth University
Huiping Zhou
Huiping Zhou University of Tsukuba
Stephen B. Edge
Stephen B. Edge Roswell Park Cancer Institute
Rajesh Ramanathan
Rajesh Ramanathan RMIT University
Phillip B. Hylemon
Phillip B. Hylemon Virginia Commonwealth University
Nicholas Farrell
Nicholas Farrell Virginia Commonwealth University

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