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Biology and Biochemistry

D-Index
54
Citations
9265
World Ranking
15746
National Ranking
6559

Overview

Li Yan is affiliated with the Roswell Park Comprehensive Cancer Center in the United States. Their research primarily focuses on oncology and molecular biology, with extensive work in cancer research and immunology. The main fields of study associated with their work include Medicine and Biochemistry, Genetics and Molecular Biology.

Yan has published numerous papers, notably in journals such as Cancers, Journal of Clinical Oncology, Cancer Research, Scientific Reports, and International Journal of Molecular Sciences. Their publications cover a wide range of topics related to cancer immunotherapy and biomarkers, ferroptosis and cancer prognosis, cancer genomics and diagnostics, immune cells in cancer, immunotherapy and immune responses, epigenetics and DNA methylation, and cancer-related molecular mechanisms research.

Some recent key papers authored by Yan include:

  • "M1 Macrophage and M1/M2 ratio defined by transcriptomic signatures resemble only part of their conventional clinical characteristics in breast cancer" (2020, Scientific Reports)
  • "CD8 T Cell Score as a Prognostic Biomarker for Triple Negative Breast Cancer" (2020, International Journal of Molecular Sciences)
  • "G2M Cell Cycle Pathway Score as a Prognostic Biomarker of Metastasis in Estrogen Receptor (ER)-Positive Breast Cancer" (2020, International Journal of Molecular Sciences)
  • "The E2F Pathway Score as a Predictive Biomarker of Response to Neoadjuvant Therapy in ER+/HER2− Breast Cancer" (2020, Cells)
  • "Abundance of Regulatory T Cell (Treg) as a Predictive Biomarker for Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer" (2020, Cancers)

Yan frequently collaborates with a core group of coauthors contributing to cancer research, including Kazuaki Takabe, Masanori Oshi, Yoshihisa Tokumaru, Itaru Endo, and Ryusei Matsuyama. These collaborations have resulted in multiple publications advancing the understanding of cancer biology and treatment.

The publication venues where Yan has contributed the most include:

  • Cancers (19 publications)
  • Journal of Clinical Oncology (10 publications)
  • Cancer Research (7 publications)
  • Scientific Reports (6 publications)
  • International Journal of Molecular Sciences (6 publications)

Yan's work has a strong emphasis on identifying and validating biomarkers for cancer prognosis and treatment response, particularly in breast cancer subtypes. Their focus on immune cells, pathway scores, and molecular mechanisms reflects an interdisciplinary approach combining clinical oncology with molecular and cellular biology.

Best Publications

  • The High Molecular Weight Urinary Matrix Metalloproteinase (MMP) Activity Is a Complex of Gelatinase B/MMP-9 and Neutrophil Gelatinase-associated Lipocalin (NGAL) MODULATION OF MMP-9 ACTIVITY BY NGAL

    Li Yan;Niels Borregaard;Lars Kjeldsen;Marsha A. Moses

  • The Matrix Metalloproteinase-9/Neutrophil Gelatinase-Associated Lipocalin Complex Plays a Role in Breast Tumor Growth and Is Present in the Urine of Breast Cancer Patients

    Cecilia A. Fernández;Li Yan;Gwendolyn Louis;Jiang Yang

  • IMA: an R package for high-throughput analysis of Illumina's 450K Infinium methylation data.

    Dan Wang;L i Yan;Qiang Hu;Lara E. Sucheston

  • Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction.

    Eric E. Gabison;Samia Mourah;Emanuelle Steinfels;Li Yan

  • Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients

    Kerry-Ann McDonald;Tsutomu Kawaguchi;Tsutomu Kawaguchi;Qianya Qi;Xuan Peng

  • CD8 T Cell Score as a Prognostic Biomarker for Triple Negative Breast Cancer.

    Masanori Oshi;Masanori Oshi;Mariko Asaoka;Mariko Asaoka;Yoshihisa Tokumaru;Yoshihisa Tokumaru;Li Yan

  • M1 Macrophage and M1/M2 ratio defined by transcriptomic signatures resemble only part of their conventional clinical characteristics in breast cancer.

    Masanori Oshi;Masanori Oshi;Yoshihisa Tokumaru;Yoshihisa Tokumaru;Mariko Asaoka;Mariko Asaoka;Li Yan

  • G2M Cell Cycle Pathway Score as a Prognostic Biomarker of Metastasis in Estrogen Receptor (ER)-Positive Breast Cancer

    Masanori Oshi;Masanori Oshi;Hideo Takahashi;Yoshihisa Tokumaru;Yoshihisa Tokumaru;Li Yan

  • Cytolytic Activity Score to Assess Anticancer Immunity in Colorectal Cancer.

    Sumana Narayanan;Tsutomu Kawaguchi;Li Yan;Xuan Peng

  • Triple-Negative Breast Cancer with High Levels of Annexin A1 Expression Is Associated with Mast Cell Infiltration, Inflammation, and Angiogenesis.

    Maiko Okano;Masanori Oshi;Ali Linsk Butash;Eriko Katsuta

  • Pancreatic adenocarcinomas with mature blood vessels have better overall survival.

    Eriko Katsuta;Qianya Qi;Xuan Peng;Steven N. Hochwald;Steven N. Hochwald

  • The E2F Pathway Score as a Predictive Biomarker of Response to Neoadjuvant Therapy in ER+/HER2- Breast Cancer.

    Masanori Oshi;Masanori Oshi;Hideo Takahashi;Yoshihisa Tokumaru;Yoshihisa Tokumaru;Li Yan

  • Clinical Relevance of microRNA Expressions in Breast Cancer Validated Using the Cancer Genome Atlas (TCGA).

    Sara Y Kim;Tsutomu Kawaguchi;Li Yan;Jessica Young

  • KRAS signaling enriched triple negative breast cancer is associated with favorable tumor immune microenvironment and better survival.

    Yoshihisa Tokumaru;Yoshihisa Tokumaru;Masanori Oshi;Eriko Katsuta;Li Yan

  • Tumor Infiltrating Lymphocytes and Macrophages Improve Survival in Microsatellite Unstable Colorectal Cancer.

    Sumana Narayanan;Tsutomu Kawaguchi;Xuan Peng;Qianya Qi

  • Circulating miR-148b and miR-133a as biomarkers for breast cancer detection

    Jie Shen;Qiang Hu;Michael Schrauder;Li Yan

  • Abundance of Regulatory T Cell (Treg) as a Predictive Biomarker for Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer.

    Masanori Oshi;Mariko Asaoka;Mariko Asaoka;Yoshihisa Tokumaru;Yoshihisa Tokumaru;Fernando A. Angarita

  • Ceramide species are elevated in human breast cancer and are associated with less aggressiveness.

    Kazuki Moro;Tsutomu Kawaguchi;Junko Tsuchida;Emmanuel Gabriel

  • Adolescent smoking in Wuhan, China: Baseline data from the Wuhan smoking prevention trial

    Jennifer B Unger;Li Yan;Xinguang Chen;Xia Jiang

  • Plasma Metabolomic Profiles in Breast Cancer Patients and Healthy Controls: By Race and Tumor Receptor Subtypes

    Jie Shen;Li Yan;Song Liu;Christine B. Ambrosone

Frequent Co-Authors

Kazuaki Takabe
Kazuaki Takabe Roswell Park Cancer Institute
Itaru Endo
Itaru Endo Yokohama City University
Stephen R. Spellman
Stephen R. Spellman Medical College of Wisconsin
Daniel O. Stram
Daniel O. Stram University of Southern California
Christine B. Ambrosone
Christine B. Ambrosone Roswell Park Cancer Institute
Christopher A. Haiman
Christopher A. Haiman University of Southern California
David Van Den Berg
David Van Den Berg University of Southern California
Kunle Odunsi
Kunle Odunsi Roswell Park Cancer Institute
Carl Morrison
Carl Morrison Roswell Park Cancer Institute
Candace S. Johnson
Candace S. Johnson Roswell Park Cancer Institute

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