World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
96
Citations
31259
World Ranking
1836
National Ranking
1010

Medicine

D-Index
96
Citations
31016
World Ranking
9747
National Ranking
5013

Overview

Phillip B. Hylemon is affiliated with Virginia Commonwealth University in the United States. Their research focuses on several intersecting areas within medicine and molecular biology with an emphasis on liver diseases and related physiological and pathological processes.

The scholar has contributed extensively to fields including Medicine with 115 publications and Biochemistry, Genetics and Molecular Biology with 34 publications. More specifically, their work addresses subfields such as Epidemiology, Hepatology, Molecular Biology, Surgery, and Oncology.

Their scientific investigations cover a range of main topics, including:

  • Liver Disease Diagnosis and Treatment
  • Drug Transport and Resistance Mechanisms
  • Liver Disease and Transplantation
  • Liver Diseases and Immunity
  • Diet, Metabolism, and Disease
  • Liver physiology and pathology
  • Pediatric Hepatobiliary Diseases and Treatments

Hylemon's frequent co-authors include Huiping Zhou, Derrick Zhao, Emily C. Gurley, Yunling Tai, and Jasmohan S. Bajaj.

Their research has been published in notable scientific venues such as:

  • Gastroenterology (14 publications)
  • Cells (5 publications)
  • Gut (3 publications)
  • Hepatology Communications (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)

Among their recent papers are:

  • "Cholangiocyte-Derived Exosomal lncRNA H19 Promotes Macrophage Activation and Hepatic Inflammation under Cholestatic Conditions," 2020, Cells
  • "Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes," 2020, PLoS ONE
  • "Interaction of bacterial metagenome and virome in patients with cirrhosis and hepatic encephalopathy," 2020, Gut
  • "Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC," 2022, Gut
  • "Bile Acid Receptors and the Gut-Liver Axis in Nonalcoholic Fatty Liver Disease," 2021, Cells

Best Publications

  • Bile salt biotransformations by human intestinal bacteria.

    Jason M. Ridlon;Dae Joong Kang;Phillip B. Hylemon

  • Bile Acids and the Gut Microbiome

    Jason M. Ridlon;Dae Joong Kang;Phillip B. Hylemon;Jasmohan S. Bajaj

  • Altered profile of human gut microbiome is associated with cirrhosis and its complications

    Jasmohan S. Bajaj;Douglas M. Heuman;Phillip B. Hylemon;Arun J. Sanyal

  • Consequences of bile salt biotransformations by intestinal bacteria

    Jason M. Ridlon;Spencer C. Harris;Shiva Bhowmik;Dae Joong Kang

  • Bile acids as regulatory molecules.

    Phillip B. Hylemon;Huiping Zhou;William M. Pandak;Shunlin Ren

  • Modulation of the Fecal Bile Acid Profile by Gut Microbiota in Cirrhosis

    Genta Kakiyama;William M. Pandak;Patrick M. Gillevet;Phillip B. Hylemon

  • Linkage of gut microbiome with cognition in hepatic encephalopathy

    Jasmohan Singh Bajaj;Jason M. Ridlon;Phillip B. Hylemon;Leroy R Thacker

  • Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation

    Jasmohan Singh Bajaj;Phillip B. Hylemon;Jason M. Ridlon;Douglas M. Heuman

  • Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy.

    Jasmohan S. Bajaj;Douglas M. Heuman;Arun J. Sanyal;Phillip B. Hylemon

  • Down-regulation of Cholesterol 7α-Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-terminal Kinase Pathway

    Seema Gupta;R. Todd Stravitz;Paul Dent;Phillip B. Hylemon

  • Cirrhosis, bile acids and gut microbiota: Unraveling a complex relationship

    Jason M. Ridlon;João Marcelo Pereira Alves;Phillip B. Hylemon;Jasmohan S. Bajaj

  • The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids

    Puneet Puri;Kalyani Daita;Andrew Joyce;Faridoddin Mirshahi

  • Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature

    Sean E McGarr;Jason M Ridlon;Phillip B Hylemon

  • Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens

    Jason M. Ridlon;Jason M. Ridlon;Shigeo Ikegawa;João M.P. Alves;Biao Zhou

  • Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy

    Jasmohan S. Bajaj;Naga S. Betrapally;Phillip B. Hylemon;Douglas M. Heuman

  • Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes.

    Elaine Studer;Xiqiao Zhou;Renping Zhao;Yun Wang

  • Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis.

    J. S. Bajaj;D. M. Heuman;P. B. Hylemon;A. J. Sanyal

  • Bile acids are nutrient signaling hormones.

    Huiping Zhou;Phillip B. Hylemon;Phillip B. Hylemon

  • Regulation of bile acid synthesis

    Z. Reno Vlahcevic;Douglas M. Heuman;Phillip B. Hylemon

  • Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat.

    W. M. Pandak;Yan Chun Li;J. Y. L. Chiang;E. J. Studer

Frequent Co-Authors

William M. Pandak
William M. Pandak Virginia Commonwealth University
Huiping Zhou
Huiping Zhou University of Tsukuba
Douglas M. Heuman
Douglas M. Heuman Virginia Commonwealth University
Jasmohan S. Bajaj
Jasmohan S. Bajaj Virginia Commonwealth University
Patrick M. Gillevet
Patrick M. Gillevet George Mason University
Masoumeh Sikaroodi
Masoumeh Sikaroodi George Mason University
Arun J. Sanyal
Arun J. Sanyal Virginia Commonwealth University
Richard K. Sterling
Richard K. Sterling Virginia Commonwealth University
Guangji Wang
Guangji Wang China Pharmaceutical University
Paul Dent
Paul Dent Virginia Commonwealth University

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