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Biology and Biochemistry

D-Index
60
Citations
10598
World Ranking
12150
National Ranking
5195

Overview

William M. Pandak is affiliated with Virginia Commonwealth University in the United States. Their research primarily focuses on medicine, with significant contributions to epidemiology, surgery, endocrinology, diabetes and metabolism, oncology, and pediatrics, perinatology, and child health.

Their main research topics include:

  • Liver Disease Diagnosis and Treatment
  • Diet, Metabolism, and Disease
  • Cholesterol and Lipid Metabolism
  • Drug Transport and Resistance Mechanisms
  • Endoplasmic Reticulum Stress and Disease
  • Lipid metabolism and biosynthesis
  • Pharmacological Effects and Toxicity Studies

William M. Pandak has published extensively, with frequent appearances in the following publication venues:

  • Gastroenterology
  • Cells
  • Journal of Lipid Research
  • American Journal of Physiology-Gastrointestinal and Liver Physiology
  • iScience

Their recent published papers include:

  • Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways, 2021, Cells
  • Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition, 2020, Journal of Lipid Research
  • High Glucose Induces Lipid Accumulation via 25-Hydroxycholesterol DNA-CpG Methylation, 2020, iScience
  • Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial, 2023, JAMA Network Open
  • Mitochondrial Cholesterol Metabolites in a Bile Acid Synthetic Pathway Drive Nonalcoholic Fatty Liver Disease: A Revised "Two-Hit" Hypothesis, 2023, Cells

Frequent co-authors working alongside William M. Pandak include:

  • Genta Kakiyama
  • Daniel Rodríguez-Agudo
  • Huiping Zhou
  • Hajime Takei
  • Hiroshi Nittono

Best Publications

  • Bile acids as regulatory molecules.

    Phillip B. Hylemon;Huiping Zhou;William M. Pandak;Shunlin Ren

  • Modulation of the Fecal Bile Acid Profile by Gut Microbiota in Cirrhosis

    Genta Kakiyama;William M. Pandak;Patrick M. Gillevet;Phillip B. Hylemon

  • Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes.

    Elaine Studer;Xiqiao Zhou;Renping Zhao;Yun Wang

  • Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis.

    J. S. Bajaj;D. M. Heuman;P. B. Hylemon;A. J. Sanyal

  • Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat.

    W. M. Pandak;Yan Chun Li;J. Y. L. Chiang;E. J. Studer

  • Prevention of free fatty acid–induced hepatic lipotoxicity by 18β-glycyrrhetinic acid through lysosomal and mitochondrial pathways

    Xudong Wu;Luyong Zhang;Emily Gurley;Elaine Studer

  • Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1‐phosphate receptor 2

    Runping Liu;Renping Zhao;Xiqiao Zhou;Xiuyin Liang

  • Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial

    G Van Assche;W J Sandborn;B G Feagan;B A Salzberg

  • Cholangiocyte-Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis.

    Runping Liu;Xiaojiaoyang Li;Weiwei Zhu;Weiwei Zhu;Yanyan Wang;Yanyan Wang

  • The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice.

    Yongqing Wang;Hiroaki Aoki;Jing Yang;Kesong Peng

  • Conjugated bile acid–activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

    Masayuki Nagahashi;Kazuaki Takabe;Runping Liu;Runping Liu;Kesong Peng

  • Colonic inflammation and secondary bile acids in alcoholic cirrhosis.

    Genta Kakiyama;Phillip B. Hylemon;Huiping Zhou;William Michael Pandak

  • Transport of Cholesterol into Mitochondria Is Rate-limiting for Bile Acid Synthesis via the Alternative Pathway in Primary Rat Hepatocytes *

    William M. Pandak;Shunlin Ren;Dalila Marques;Elizabeth Hall

  • LXRα is the dominant regulator of CYP7A1 transcription

    Seema Gupta;William M Pandak;Phillip B Hylemon

  • Hormonal regulation of cholesterol 7 alpha-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures.

    P B Hylemon;E C Gurley;R T Stravitz;J S Litz

  • A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: validation by GC-MS and LC-MS

    Genta Kakiyama;Akina Muto;Hajime Takei;Hiroshi Nittono

  • Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat.

    ZR Vlahcevic;RT Stravitz;DM Heuman;PB Hylemon

  • Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans.

    Xiaojiaoyang Li;Runping Liu;Zhiming Huang;Emily C. Gurley

  • The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis : A known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis

    Antonio del Castillo-Olivares;José A. Campos;William M. Pandak;Gregorio Gil

  • HIV Protease Inhibitors Activate the Unfolded Protein Response and Disrupt Lipid Metabolism in Primary Hepatocytes

    Huiping Zhou;Emily C. Gurley;Sirikalaya Jarujaron;Hong Ding

Frequent Co-Authors

Phillip B. Hylemon
Phillip B. Hylemon Virginia Commonwealth University
Huiping Zhou
Huiping Zhou University of Tsukuba
Douglas M. Heuman
Douglas M. Heuman Virginia Commonwealth University
Jasmohan S. Bajaj
Jasmohan S. Bajaj Virginia Commonwealth University
Arun J. Sanyal
Arun J. Sanyal Virginia Commonwealth University
Patrick M. Gillevet
Patrick M. Gillevet George Mason University
Masoumeh Sikaroodi
Masoumeh Sikaroodi George Mason University
Guangji Wang
Guangji Wang China Pharmaceutical University
John Y. L. Chiang
John Y. L. Chiang Northeast Ohio Medical University
Oliver Fiehn
Oliver Fiehn University of California, Davis

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