World's Best Scientists 2026 revealed!

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Medicine

D-Index
113
Citations
44812
World Ranking
4976
National Ranking
2701

Research.com Recognitions

  • 1982 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1979 - William Beaumont Prize, American Gastroenterological Association (AGA)

Overview

Alan F. Hofmann is affiliated with the University of California, San Diego in the United States. Their research contributions focus primarily on medicine with a specialization in oncology, hepatology, surgery, epidemiology, and public health, environmental and occupational health. The scientist's work spans various topics including drug transport and resistance mechanisms, liver diseases and immunity, pediatric hepatobiliary diseases and treatments, liver disease diagnosis and treatment, reproductive biology and fertility, ovarian cancer diagnosis and treatment, and cancer risks and factors.

The main publication venues for their research include the Journal of Hepatology, Cellular and Molecular Gastroenterology and Hepatology, and Reproduction.

Recent papers authored or co-authored by Alan F. Hofmann showcase a focus on liver diseases and treatments. Notable publications include:

  • "Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis," 2020, Journal of Hepatology
  • "Quantifying the Complexities of Bile Acid Metabolism in Man: Continued Progress," 2020, Cellular and Molecular Gastroenterology and Hepatology
  • "Reply to: 'Obeticholic acid and hepatic bile acids: Excellent study faulty conclusion,'" 2021, Journal of Hepatology
  • "Mechanisms of chemotherapy-induced oocyte death through activation of TAp63α," 2025, Reproduction

Frequent co-authors in their research include:

  • Kim Frisch
  • Susanne Keiding
  • Kristoffer Kjærgaard
  • Michael Sørensen
  • Ole Lajord Munk

Alan F. Hofmann's scholarly focus in medicine is further characterized by attention to subfields such as oncology, hepatology, surgery, epidemiology, and public health-related studies.

Awards received by Alan F. Hofmann are the Fellow of the American Association for the Advancement of Science (AAAS) awarded in 1982 and the William Beaumont Prize from the American Gastroenterological Association (AGA) awarded in 1979.

Best Publications

  • The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver.

    Thomas Gerloff;Bruno Stieger;Bruno Hagenbuch;Jerzy Madon

  • The Continuing Importance of Bile Acids in Liver and Intestinal Disease

    Alan F. Hofmann

  • Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

    A. F. Hofmann;L. R. Hagey

  • Dissolution of cholesterol gallstones by chenodeoxycholic acid.

    Rudy G. Danzinger;Alan F. Hofmann;Leslie J. Schoenfield;Johnson L. Thistle

  • Role of Bile Acid Malabsorption in Pathogenesis of Diarrhea and Steatorrhea in Patients with Ileal Resection: I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride

    Alan F. Hofmann;J. Rainer Poley

  • Detergent Properties of Bile Salts: Correlation with Physiological Function

    and A F Hofmann;D M Small

  • Colonic Secretion of Water and Electrolytes Induced by Bile Acids: Perfusion Studies in Man

    H S Mekjian;S F Phillips;A F Hofmann

  • Ursodeoxycholic acid in the treatment of primary biliary cirrhosis

    Keith D. Lindor;E.Rolland Dickson;William P. Baldus;Roberta A. Jorgensen

  • Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.

    Gerd A. Kullak-Ublick;Bruno Hagenbuch;Bruno Stieger;Claudio D. Schteingart

  • THE INTRALUMINAL PHASE OF FAT DIGESTION IN MAN: THE LIPID CONTENT OF THE MICELLAR AND OIL PHASES OF INTESTINAL CONTENT OBTAINED DURING FAT DIGESTION AND ABSORPTION.

    Alan F. Hofmann;Bengt Borgström

  • Bile Acids: The Good, the Bad, and the Ugly.

    Alan F. Hofmann

  • Origin of myofibroblasts in the fibrotic liver in mice

    Keiko Iwaisako;Chunyan Jiang;Mingjun Zhang;Min Cong

  • Letter: A simple calculation of the lithogenic index of bile: expressing biliary lipid composition on rectangular coordinates.

    Paul J. Thomas;Alan F. Hofmann

  • The bile acid TGR5 membrane receptor: from basic research to clinical application.

    Henri Duboc;Yvette Taché;Alan F. Hofmann

  • Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis part II

    William H. Bachrach;William H. Bachrach;Alan F. Hofmann;Alan F. Hofmann

  • Bile salts of vertebrates: structural variation and possible evolutionary significance.

    Alan F. Hofmann;Lee R. Hagey;Matthew D. Krasowski

  • Prospective Comparison of Indirect Methods for Detecting Lactase Deficiency

    Albert D. Newcomer;Douglas B. McGill;Paul J. Thomas;Alan F. Hofmann

  • Increased reflux of bile into the stomach in patients with gastric ulcer.

    John Rhodes;David E. Barnardo;Sidney F. Phillips;Randolph A. Rovelstad

  • The Enterohepatic Circulation of Bile Acids in Man

    Alan F. Hofmann

  • A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis

    Burton Combes;Robert L. Carithers;Willis C. Maddrey;Willis C. Maddrey;Danyu Lin

Frequent Co-Authors

Michael Trauner
Michael Trauner Medical University of Vienna
William I. Higuchi
William I. Higuchi University of Utah
Aldo Roda
Aldo Roda University of Bologna
John M. Lachin
John M. Lachin George Washington University
Keith D. Lindor
Keith D. Lindor Arizona State University
Bengt Borgström
Bengt Borgström Lund University
Phillip B. Hylemon
Phillip B. Hylemon Virginia Commonwealth University
Bruno Stieger
Bruno Stieger University of Zurich

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