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D-Index & Metrics

Genetics

D-Index
47
Citations
7623
World Ranking
4129
National Ranking
19

Overview

G. Jane Farrar is affiliated with Trinity College Dublin in Ireland and is an active researcher in the fields of biochemistry, genetics, and molecular biology, with additional work in medicine. Their research portfolio includes 61 publications in biochemistry, genetics, and molecular biology, and 16 in medicine, reflecting a strong interdisciplinary focus. The scientist's subfields of study emphasize molecular biology, genetics, and ophthalmology, alongside sensory systems and cell biology.

The main topics of Farrar's research focus on retinal development and disorders, retinal diseases and treatments, CRISPR and genetic engineering, RNA regulation and disease, genomics and rare diseases, virus-based gene therapy research, and advanced biosensing and bioanalysis techniques.

Recent publications by Farrar include:

  • Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids (2020, Stem Cell Reports)
  • Next-Generation Sequencing Applications for Inherited Retinal Diseases (2021, International Journal of Molecular Sciences)
  • Findings from a Genotyping Study of over 1000 People with Inherited Retinal Disorders in Ireland (2020, Genes)
  • Whole genome sequencing and in vitro splice assays reveal genetic causes for inherited retinal diseases (2021, npj Genomic Medicine)
  • Usher syndrome type IV: clinically and molecularly confirmed by novel ARSG variants (2022, Human Genetics)

Farrar frequently publishes in a variety of scientific journals. The most common venues include:

  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genes
  • Frontiers in Neuroscience
  • Scientific Reports

Throughout their career, Farrar has collaborated closely with several co-authors, including:

  • Paul F. Kenna
  • Naomi Chadderton
  • Arpad Palfi
  • Adrian Dockery
  • Laura Whelan

Best Publications

  • Retinopathy induced in mice by targeted disruption of the rhodopsin gene

    Humphries Mm;Rancourt D;Farrar Gj;Kenna P;Kenna P

  • NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

    Sarah L. Doyle;Matthew Campbell;Ema Ozaki;Robert G. Salomon

  • Autosomal dominant retinitis pigmentosa (ADRP): Localization of an ADRP gene to the long arm of chromosome 3

    Peter McWilliam;G.Jane Farrar;Paul Kenna;Daniel G. Bradley

  • On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention

    G. Jane Farrar;Paul F. Kenna;Peter Humphries

  • On the molecular genetics of retinitis pigmentosa

    P Humphries;P Kenna;GJ Farrar

  • Effective delivery of large genes to the retina by dual AAV vectors

    Ivana Trapani;Pasqualina Colella;Andrea Sommella;Carolina Iodice

  • RNA interference-mediated suppression and replacement of human rhodopsin in vivo.

    Mary O’Reilly;Arpad Palfi;Naomi Chadderton;Sophia Millington-Ward

  • Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice.

    Udo Bartsch;Wasi Oriyakhel;Paul F. Kenna;Stephan Linke

  • Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa.

    Carol J Loscher;Karsten Hokamp;Paul F Kenna;Alasdair C Ivens

  • Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy.

    Naomi Chadderton;Sophia Millington-Ward;Arpad Palfi;Mary O'Reilly

  • Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa

    Sophia Millington-Ward;Naomi Chadderton;Mary O'Reilly;Arpad Palfi

  • A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement

    Sara J. Bowne;Marian M. Humphries;Lori S. Sullivan;Paul F. Kenna;Paul F. Kenna

  • Autosomal dominant retinitis pigmentosa: linkage to rhodopsin and evidence for genetic heterogeneity

    G. Jane Farrar;Peter McWilliam;Daniel G. Bradley;Paul Kenna

  • CHD5 Is Required for Neurogenesis and Has a Dual Role in Facilitating Gene Expression and Polycomb Gene Repression

    Chris M. Egan;Ulrika Nyman;Julie Skotte;Gundula Streubel

  • Retinitis Pigmentosa and Progressive Sensorineural Hearing Loss Caused by a C12258A Mutation in the Mitochondrial MTTS2 Gene

    Fiona C. Mansergh;Sophia Millington-Ward;Avril Kennan;Anna-Sophia Kiang

  • Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids.

    Amelia Lane;Katarina Jovanovic;Ciara Shortall;Daniele Ottaviani

  • A NOVEL MUTATION WITHIN THE RHODOPSIN GENE (THR-94-ILE) CAUSING AUTOSOMAL DOMINANT CONGENITAL STATIONARY NIGHT BLINDNESS

    Najma al-Jandal;G. Jane Farrar;Anna-Sophia Kiang;Marian M. Humphries

  • Toward a Gene Therapy for Dominant Disease: Validation of an RNA Interference-Based Mutation-Independent Approach

    Anna-Sophia Kiang;Arpad Palfi;Marius Ader;Paul F. Kenna

  • Autosomal dominant retinitis pigmentosa: localization of a disease gene (RP6) to the short arm of chromosome 6.

    G.Jane Farrar;Siobhán A. Jordan;Paul Kenna;Marian M. Humphries

  • On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa

    Aileen Aherne;Avril Kennan;Paul F. Kenna;Niamh McNally

Frequent Co-Authors

Paul F. Kenna
Paul F. Kenna Trinity College Dublin
Peter Humphries
Peter Humphries Trinity College Dublin
Frans P.M. Cremers
Frans P.M. Cremers Radboud University
Karsten Hokamp
Karsten Hokamp Trinity College Dublin
Caroline C W Klaver
Caroline C W Klaver Erasmus University Rotterdam
Stephen P. Daiger
Stephen P. Daiger The University of Texas Health Science Center at Houston
Alison J. Hardcastle
Alison J. Hardcastle University College London
Christian Gilissen
Christian Gilissen Radboud University
Daniel G. Bradley
Daniel G. Bradley Trinity College Dublin
Uwe Wolfrum
Uwe Wolfrum Johannes Gutenberg University of Mainz

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