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Biology and Biochemistry

D-Index
52
Citations
10646
World Ranking
16617
National Ranking
1313

Overview

Jane C. Sowden is affiliated with University College London in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Neuroscience. Within these fields, Sowden's work is focused on several subfields including Molecular Biology, Genetics, Cellular and Molecular Neuroscience, Ophthalmology, and Neurology.

The main topics of Sowden's research involve retinal and ocular health, with particular emphasis on:

  • Retinal Development and Disorders
  • Ocular Disorders and Treatments
  • CRISPR and Genetic Engineering
  • Photoreceptor and Optogenetics Research
  • RNA Regulation and Disease
  • Retinal Diseases and Treatments
  • Neurological Diseases and Metabolism

Sowden has contributed to scientific literature in several notable venues. Frequently publishing in:

  • Scientific Reports
  • Stem Cells
  • Ophthalmology
  • Nature Communications
  • Journal of Autism and Developmental Disorders

Some of the recent papers authored or co-authored by Sowden include:

  • Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina, 2024, Nature Communications
  • NRL −/− gene edited human embryonic stem cells generate rod-deficient retinal organoids enriched in S-cone-like photoreceptors, 2021, Stem Cells
  • Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder, 2020, Journal of Autism and Developmental Disorders
  • Molecular pathology of Usher 1B patient-derived retinal organoids at single cell resolution, 2022, Stem Cell Reports
  • Spectrum of Mutations in NDP Resulting in Ocular Disease; a Systematic Review, 2022, Frontiers in Genetics

Frequent collaborators working alongside Sowden include:

  • Aara Patel
  • Yeh Chwan Leong
  • Wolfgang Berger
  • Karen P. Steel
  • Paul A. Constable

Best Publications

  • Retinal Repair by Transplantation of Photoreceptor Precursors

    R. E. MacLaren;R. A. Pearson;A. MacNeil;R. H. Douglas

  • Restoration of vision after transplantation of photoreceptors

    R. A. Pearson;A. C. Barber;M. Rizzi;C. Hippert

  • Fox's in development and disease.

    Ordan J Lehmann;Jane C Sowden;Peter Carlsson;Tim Jordan

  • Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina

    Anai Gonzalez-Cordero;Emma L West;Rachael A Pearson;Yanai Duran

  • A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene

    Maria Bitner-Glindzicz;Keith J. Lindley;Paul Rutland;Diana Blaydon

  • Human microphthalmia associated with mutations in the retinal homeobox gene CHX10.

    E Ferda Percin;L A Ploder;J J Yu;K Arici

  • A single-cell transcriptome atlas of the adult human retina

    Samuel W. Lukowski;Camden Y. Lo;Alexei A. Sharov;Quan Nguyen

  • Repair of the degenerate retina by photoreceptor transplantation

    Amanda C. Barber;Claire Hippert;Yanai Duran;Emma L. West

  • Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors.

    R. A. Pearson;A. Gonzalez-Cordero;E. L. West;J. R. Ribeiro

  • Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors

    Anai Gonzalez-Cordero;Kamil Kruczek;Arifa Naeem;Milan Fernando

  • A review of anterior segment dysgeneses.

    Faisal Idrees;Daniela Vaideanu;Scott G. Fraser;Jane C. Sowden

  • Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors.

    E.L. West;R.A. Pearson;M. Tschernutter;J.C. Sowden

  • Molecular and developmental mechanisms of anterior segment dysgenesis

    J C Sowden

  • Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH

    Julian Morcillo;Juan Ramon Martínez-Morales;Françoise Trousse;Yasmin Fermin

  • Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.

    Celene Grayson;Silvia N.M. Reid;Juliet A. Ellis;Adam Rutherford

  • Defining the Integration Capacity of Embryonic Stem Cell-Derived Photoreceptor Precursors†‡§

    Emma L. West;Anai Gonzalez-Cordero;Claire Hippert;Fumitaka Osakada

  • Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina.

    R. A. Pearson;A. C. Barber;E. L. West;R. E. Maclaren

  • Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation.

    Emma L. West;Rachael A. Pearson;Susie E. Barker;Ulrich F.O. Luhmann

  • The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup

    Hourinaz Behesti;James K L Holt;Jane C Sowden

  • Retinoschisin, the X-linked Retinoschisis protein, is a secreted photoreceptor protein.

    D Trump;C Grayson;Snm Reid;J Sowden

Frequent Co-Authors

Robin R. Ali
Robin R. Ali King's College London
Peng T. Khaw
Peng T. Khaw University College London
Michael A. Walter
Michael A. Walter University of Alberta
Anthony T. Moore
Anthony T. Moore University of California, San Francisco
Shomi S. Bhattacharya
Shomi S. Bhattacharya University College London
Clare Gilbert
Clare Gilbert London School of Hygiene & Tropical Medicine
Scott E. Fraser
Scott E. Fraser University of Southern California
Mike Hubank
Mike Hubank Royal Marsden NHS Foundation Trust
Joseph E. Powell
Joseph E. Powell Garvan Institute of Medical Research
Alex W. Hewitt
Alex W. Hewitt University of Tasmania

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