World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
100
Citations
43476
World Ranking
8190
National Ranking
4246

Overview

Kenneth D. R. Setchell is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research spans a broad array of topics within medicine, particularly focused on pediatric hepatobiliary diseases and treatments, drug transport and resistance mechanisms, and metabolism and genetic disorders. Additional areas of their work include neonatal health and biochemistry, hematopoietic stem cell transplantation, prenatal substance exposure effects, and tuberous sclerosis complex research.

Their main field of study is medicine, with a notable focus on subfields such as surgery, molecular biology, oncology, hematology, and pediatrics, perinatology, and child health.

Among their frequent co-authors are:

  • Xueheng Zhao
  • Wujuan Zhang
  • Junfang Zhao
  • Mónica Narváez-Rivas
  • Najeeha Talat Iqbal

Setchell has published extensively in several scientific journals, with numerous papers appearing in Gastroenterology, Journal of Pediatric Gastroenterology and Nutrition, Metabolites, Transplantation and Cellular Therapy, and SSRN Electronic Journal.

Selected recent papers include:

  • Efficacy and safety of maralixibat treatment in patients with Alagille syndrome and cholestatic pruritus (ICONIC): a randomised phase 2 study, 2021, The Lancet
  • Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice, 2020, Aging Cell
  • Maralixibat for the treatment of PFIC: Long-term, IBAT inhibition in an open-label, Phase 2 study, 2022, Hepatology Communications
  • Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis, 2022, Science Translational Medicine
  • Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy, 2022, Hepatology

Best Publications

  • Soy intake and cancer risk: A review of the in vitro and in vivo data

    Mark J. Messina;Victoria Persky;Kenneth D. R. Setchell;Stephen Barnes

  • The Clinical Importance of the Metabolite Equol—A Clue to the Effectiveness of Soy and Its Isoflavones

    Kenneth D. R. Setchell;Nadine M. Brown;Eva Lydeking-Olsen

  • Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones.

    K. D. R. Setchell

  • Dietary Isoflavones: Biological Effects and Relevance to Human Health

    Kenneth D. R. Setchell;Aedin Cassidy

  • Genistein, daidzein, and their .beta.-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets

    Lori. Coward;Neil C. Barnes;Kenneth D. R. Setchell;Stephen. Barnes

  • Bioavailability of Pure Isoflavones in Healthy Humans and Analysis of Commercial Soy Isoflavone Supplements

    Kenneth D. R. Setchell;Nadine M. Brown;Pankaj Desai;Linda Zimmer-Nechemias

  • Bile acid biosynthesis

    David W. Russell;Kenneth D. R. Setchell

  • Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women.

    A. Cassidy;S. Bingham;K. D. R. Setchell

  • Exposure of infants to phyto-oestrogens from soy-based infant formula

    Kenneth Dr Setchell;Linda Zimmer-Nechemias;Jinnan Cai;James E Heubi

  • Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease.

    K. D. R. Setchell;S. P. Borriello;P. Hulme;D. N. Kirk

  • Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability.

    Kenneth D R Setchell;Nadine M Brown;Linda Zimmer-Nechemias;Wayne T Brashear

  • S-Equol, a potent ligand for estrogen receptor β, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora

    Kenneth D R Setchell;Carlo Clerici;Edwin D Lephart;Sidney J Cole

  • Equol: History, Chemistry, and Formation

    Kenneth D. R. Setchell;Carlo Clerici

  • Origin of lignans in mammals and identification of a precursor from plants

    M. Axelson;J. Sjövall;B. E. Gustafsson;K. D. R. Setchell

  • Soybeans inhibit mammary tumors in models of breast cancer.

    S Barnes;C Grubbs;K D Setchell;J Carlson

  • Production and metabolism of lignans by the human faecal flora.

    S.P. Borriello;K.D.R. Setchell;M. Axelson;A.M. Lawson

  • Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies

    Kenneth D R Setchell;Eva Lydeking-Olsen

  • Soy isoflavones--benefits and risks from nature's selective estrogen receptor modulators (SERMs).

    Kenneth D. R. Setchell

  • Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life.

    K D Setchell;L Zimmer-Nechemias;J Cai;J E Heubi

  • Dietary estrogens--a probable cause of infertility and liver disease in captive cheetahs.

    K.D.R. Setchell;S.J. Gosselin;M.B. Welsh;J.O. Johnston

Frequent Co-Authors

David P. Witte
David P. Witte Cincinnati Children's Hospital Medical Center
Cecília M. P. Rodrigues
Cecília M. P. Rodrigues University of Lisbon
Antonio Morelli
Antonio Morelli University of Perugia
Mauro Podda
Mauro Podda University of Cagliari
Randy J. Seeley
Randy J. Seeley University of Michigan–Ann Arbor
Roberto Pellicciari
Roberto Pellicciari University of Perugia
David W. Russell
David W. Russell University of Washington
Gregory A. Grabowski
Gregory A. Grabowski University of Cincinnati Medical Center
Jan Sjövall
Jan Sjövall Karolinska Institute
Jörg Köhl
Jörg Köhl University of Lübeck

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

If you’re interested in alternative or complementary routes to a career in medicine, many flexible online degrees can support your goals. Pursuing advanced nursing credentials is becoming increasingly popular. For instance, students seeking affordable post-graduate options may consider the cheapest dnp program online, which offers a cost-effective way to achieve a Doctor of Nursing Practice.

Those who want to quickly enter the workforce might explore a 6 month lpn program online. These programs provide a streamlined path into essential patient care roles with minimal time commitment.

Mental health is also a growing field in healthcare. The psychiatric np programs online allow registered nurses to specialize in mental health and serve communities in need.

For those more interested in the business side of healthcare, the cheapest online healthcare administration degree can help you start or advance a career in hospital or clinic management.

Best Scientists Citing Kenneth D. R. Setchell

Trending Scientists