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Biology and Biochemistry

D-Index
55
Citations
8487
World Ranking
15275
National Ranking
6378

Overview

Julie D. Saba is affiliated with the University of California, San Francisco in the United States. Their research primarily focuses on medical and biochemical aspects of sphingolipid metabolism and related pathophysiological processes.

The main fields of study addressed by Julie D. Saba include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broad fields, the following subfields have been a focus of their work:

  • Molecular Biology
  • Physiology
  • Pathology and Forensic Medicine
  • Immunology
  • Pulmonary and Respiratory Medicine

Their research covers several key topics, particularly:

  • Sphingolipid Metabolism and Signaling
  • Erythrocyte Function and Pathophysiology
  • Biomedical Research and Pathophysiology
  • Lysosomal Storage Disorders Research
  • Carbohydrate Chemistry and Synthesis
  • Ion Transport and Channel Regulation
  • Ubiquitin and proteasome pathways

Julie D. Saba has contributed to multiple scientific publications across various venues. Frequent publication venues include:

  • International Journal of Molecular Sciences
  • Journal of Cystic Fibrosis
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Inherited Metabolic Disease
  • JCI Insight

Significant papers authored or coauthored include:

  • "Genotype/Phenotype Interactions and First Steps Toward Targeted Therapy for Sphingosine Phosphate Lyase Insufficiency Syndrome", 2021, Cell Biochemistry and Biophysics
  • "Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation", 2020, Journal of Inherited Metabolic Disease
  • "Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome", 2021, JCI Insight
  • "MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome", 2020, American Journal of Neuroradiology
  • "Sphingosine phosphate lyase insufficiency syndrome: a systematic review", 2022, World Journal of Pediatrics

The scientist has collaborated frequently with several coauthors, including:

  • Babak Oskouian
  • Ranjha Khan
  • Barbara Cellini
  • Marilena Pariano
  • Roberta Galarini

Best Publications

  • An update on sphingosine-1-phosphate and other sphingolipid mediators.

    Henrik Fyrst;Julie D Saba

  • Point-Counterpoint of Sphingosine 1-Phosphate Metabolism

    Julie D. Saba;Timothy Hla

  • The BST1 Gene of Saccharomyces cerevisiaeIs the Sphingosine-1-phosphate Lyase *

    Julie D. Saba;Futoshi Nara;Alicia Bielawska;Steven Garrett

  • γ-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis

    Qing Jiang;Jeffrey Wong;Henrik Fyrst;Julie D. Saba

  • Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.

    Masataka Kohno;Michiko Momoi;Myat Lin Oo;Ji-Hye Paik

  • Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer

    Babak Oskouian;Prathap Sooriyakumaran;Alexander D. Borowsky;Angelina Crans

  • Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression.

    Masayasu Kitano;Timothy Hla;Masahiro Sekiguchi;Yutaka Kawahito

  • Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

    Meryem Bektas;Maria Laura Allende;Bridgin G. Lee;WeiPing Chen

  • Activation of Sphingosine Kinase-1 Reverses the Increase in Lung Vascular Permeability Through Sphingosine-1-Phosphate Receptor Signaling in Endothelial Cells

    Mohammad Tauseef;Vidisha Kini;Nebojsa Knezevic;Melissa Brannan

  • Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast.

    Jianhui Zhou;Julie D. Saba

  • Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function

    Montserrat Serra;Julie D. Saba

  • Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.

    Maria L. Allende;Meryem Bektas;Bridgin G. Lee;Eliana Bonifacino

  • Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

    Svjetlana Lovric;Sara Goncalves;Sara Goncalves;Heon Yung Gee;Babak Oskouian

  • The Immune Modulator FTY720 Inhibits Sphingosine-1-phosphate Lyase Activity

    Padmavathi Bandhuvula;Yuen Yee Tam;Babak Oskouian;Julie D. Saba

  • Sphingosine-phosphate Lyase Enhances Stress-induced Ceramide Generation and Apoptosis

    Ulrike Reiss;Babak Oskouian;Jianhui Zhou;Vinita Gupta

  • Cancer treatment strategies targeting sphingolipid metabolism.

    Babak Oskouian;Julie D. Saba

  • Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs

    Emilie Degagné;Ashok Pandurangan;Padmavathi Bandhuvula;Ashok Kumar

  • Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren.

    Padmavathi Bandhuvula;Julie D. Saba

  • The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses.

    Cungui Mao;Julie D. Saba;Lina M. Obeid

  • Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania

    Kai Zhang;Justine M Pompey;Fong-Fu Hsu;Phillip Key

Frequent Co-Authors

Robert Bittman
Robert Bittman City University of New York
Richard L. Proia
Richard L. Proia National Institutes of Health
Viswanathan Natarajan
Viswanathan Natarajan University of Illinois at Chicago
Martin Zenker
Martin Zenker Otto-von-Guericke University Magdeburg
Friedhelm Hildebrandt
Friedhelm Hildebrandt Boston Children's Hospital
Joe G.N. Garcia
Joe G.N. Garcia University of Arizona
Dan Ehninger
Dan Ehninger German Center for Neurodegenerative Diseases
Pieter J. de Jong
Pieter J. de Jong UCSF Benioff Children's Hospital
Corinne Antignac
Corinne Antignac Institut Imagine
Richard P. Lifton
Richard P. Lifton Rockefeller University

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