World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
11267
World Ranking
17515
National Ranking
7193

Overview

Dolly Mehta is affiliated with the University of Illinois at Chicago in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, medicine, immunology, and microbiology. The scientist has contributed extensively to both main fields and subfields, covering topics related to molecular biology, immunology, pulmonary and respiratory medicine, cell biology, and physiology.

Areas of research focus include:

  • Neonatal respiratory health research
  • Sphingolipid metabolism and signaling
  • Neutrophil, myeloperoxidase, and oxidative mechanisms
  • Immune response and inflammation
  • Interferon and immune responses
  • Inflammasome and immune disorders
  • Immune cells in cancer

Mehta has published in various venues, predominantly contributing to:

  • The FASEB Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Physiology
  • iScience
  • Journal of Clinical Investigation

Frequent collaborators include Jagdish Chandra Joshi, Md Zahid Akhter, Mumtaz Anwar, V. Vigneshwaran, and Bhagwati Joshi.

Notable papers authored or co-authored by Mehta encompass:

  • "IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury," published in 2020 in the Journal of Clinical Investigation
  • "Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair," published in 2020 in Frontiers in Immunology
  • "SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages," published in 2020 in Cell Reports
  • "Cell-Matrix Interactions Regulate Functional Extracellular Vesicle Secretion from Mesenchymal Stromal Cells," published in 2021 in ACS Nano
  • "Programming to S1PR1 + Endothelial Cells Promotes Restoration of Vascular Integrity," published in 2021 in Circulation Research

The research contributions include extensive investigation into inflammatory injury mechanisms, vascular repair, and cellular signaling pathways. Mehta's work also involves studies on extracellular vesicle secretion and endothelial cell programming relevant to vascular health.

Best Publications

  • Signaling Mechanisms Regulating Endothelial Permeability

    Dolly Mehta;Asrar B. Malik

  • Regulation of endothelial junctional permeability.

    Emily Vandenbroucke;Dolly Mehta;Richard Minshall;Asrar B. Malik

  • Impairment of Store-Operated Ca2+ Entry in TRPC4-/- Mice Interferes With Increase in Lung Microvascular Permeability

    Chinnaswamy Tiruppathi;Marc Freichel;Stephen M. Vogel;Biman C. Paria

  • Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability

    Yulia A. Komarova;Kevin Kruse;Dolly Mehta;Asrar B. Malik

  • Protein Kinase C-α Signals Rho-Guanine Nucleotide Dissociation Inhibitor Phosphorylation and Rho Activation and Regulates the Endothelial Cell Barrier Function

    Dolly Mehta;Arshad Rahman;Asrar B. Malik

  • Mechanisms Regulating Endothelial Permeability

    Sukriti Sukriti;Mohammad Tauseef;Pascal Yazbeck;Dolly Mehta

  • RhoA Interaction with Inositol 1,4,5-Trisphosphate Receptor and Transient Receptor Potential Channel-1 Regulates Ca2+ Entry ROLE IN SIGNALING INCREASED ENDOTHELIAL PERMEABILITY

    Dolly Mehta;Gias U. Ahmmed;Biman C. Paria;Michael Holinstat

  • Gαq-TRPC6-mediated Ca2+ Entry Induces RhoA Activation and Resultant Endothelial Cell Shape Change in Response to Thrombin

    Itender Singh;Nebojsa Knezevic;Gias U. Ahmmed;Vidisha Kini

  • TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation

    Mohammad Tauseef;Nebojsa Knezevic;Koteswara R. Chava;Monica Smith

  • Dual regulation of endothelial junctional permeability.

    Yulia A. Komarova;Dolly Mehta;Asrar B. Malik

  • Role of Protein Tyrosine Phosphatase 1B in Vascular Endothelial Growth Factor Signaling and Cell–Cell Adhesions in Endothelial Cells

    Yoshimasa Nakamura;Nikolay Patrushev;Hyoe Inomata;Dolly Mehta

  • Activation of Sphingosine Kinase-1 Reverses the Increase in Lung Vascular Permeability Through Sphingosine-1-Phosphate Receptor Signaling in Endothelial Cells

    Mohammad Tauseef;Vidisha Kini;Nebojsa Knezevic;Melissa Brannan

  • Angiopoietin-1 Opposes VEGF-Induced Increase in Endothelial Permeability by Inhibiting TRPC1-Dependent Ca2+ Influx

    David Jho;Dolly Mehta;Gias Ahmmed;Xiao Pei Gao

  • Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.

    Michael Holinstat;Nebojsa Knezevic;Michael Broman;Allen M. Samarel

  • Protein Kinase Cα-Induced p115RhoGEF Phosphorylation Signals Endothelial Cytoskeletal Rearrangement

    Michael Holinstat;Dolly Mehta;Tohru Kozasa;Richard D. Minshall

  • Protein kinase Cα phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.

    Gias U. Ahmmed;Dolly Mehta;Stephen Vogel;Michael Holinstat

  • Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells.

    Dolly Mehta;Maria Konstantoulaki;Gias U. Ahmmed;Asrar B. Malik

  • Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice

    Stephen M. Vogel;Xiaopei Gao;Dolly Mehta;Richard D. Ye

  • IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury

    Shiqin Xiong;Zhigang Hong;Long Shuang Huang;Yoshikazu Tsukasaki

  • Novel regulators of endothelial barrier function

    Dolly Mehta;Krishnan Ravindran;Wolfgang M. Kuebler;Wolfgang M. Kuebler;Wolfgang M. Kuebler

Frequent Co-Authors

Asrar B. Malik
Asrar B. Malik University of Illinois at Chicago
Stephen M. Vogel
Stephen M. Vogel University of Illinois at Chicago
Chinnaswamy Tiruppathi
Chinnaswamy Tiruppathi University of Illinois at Chicago
Richard D. Minshall
Richard D. Minshall University of Illinois at Chicago
Ruxana T. Sadikot
Ruxana T. Sadikot University of Nebraska Medical Center
Lutz Birnbaumer
Lutz Birnbaumer National Institutes of Health
Sekhar P. Reddy
Sekhar P. Reddy University of Illinois at Chicago
Jun-Lin Guan
Jun-Lin Guan University of Cincinnati Medical Center
Jalees Rehman
Jalees Rehman University of Illinois at Chicago
Viswanathan Natarajan
Viswanathan Natarajan University of Illinois at Chicago

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