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Neuroscience

D-Index
35
Citations
7718
World Ranking
9119
National Ranking
3843

Overview

William J. Spain is affiliated with the University of Washington in the United States. Their research spans across several domains within neuroscience and molecular biology, with a focus on neural dynamics, ion channel regulation, and neuropharmacology.

The main fields of study associated with Spain include Neuroscience and Biochemistry, Genetics and Molecular Biology. Their work further delves into specific subfields such as Cellular and Molecular Neuroscience, Molecular Biology, Cognitive Neuroscience, and Electrical and Electronic Engineering.

The primary research topics explored by Spain cover Neuroscience and Neuropharmacology Research, Ion channel regulation and function, Neural dynamics and brain function, Advanced Memory and Neural Computing, and Photoreceptor and optogenetics research.

Spain has contributed to several recent scientific publications, including:

  • "Kv2.1 Potassium Channels Regulate Repetitive Burst Firing in Extratelencephalic Neocortical Pyramidal Neurons" (2021) published in Cerebral Cortex
  • "GABA-B receptors enhance GABA-A receptor currents by modulation of membrane trafficking in dentate gyrus granule cells" (2022) published in Neuroscience Letters
  • "Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons" (2025) published in bioRxiv (Cold Spring Harbor Laboratory)

Their collaborative network includes frequent coauthors such as Nikolai Dembrow, Greg S Newkirk, Dongxu Guan, William E. Armstrong, and Robert C. Foehring.

Spain's research outputs have appeared in notable scientific venues, predominantly in Cerebral Cortex, Neuroscience Letters, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy

    Frank H Yu;Massimo Mantegazza;Ruth E Westenbroek;Carol A Robbins

  • Comparative cellular analysis of motor cortex in human, marmoset and mouse

    Trygve E. Bakken;Nikolas L. Jorstad;Qiwen Hu;Blue B. Lake

  • Fractional differentiation by neocortical pyramidal neurons.

    Brian Nils Lundstrom;Matthew H Higgs;Matthew H Higgs;William J Spain;William J Spain;Adrienne L Fairhall

  • Multiple potassium conductances and their functions in neurons from cat sensorimotor cortex in vitro

    P. C. Schwindt;W. J. Spain;R. C. Foehring;C. E. Stafstrom

  • Slow conductances in neurons from cat sensorimotor cortex in vitro and their role in slow excitability changes

    P. C. Schwindt;W. J. Spain;R. C. Foehring;M. C. Chubb

  • Long-lasting reduction of excitability by a sodium-dependent potassium current in cat neocortical neurons.

    P. C. Schwindt;W. J. Spain;W. E. Crill

  • Anomalous rectification in neurons from cat sensorimotor cortex in vitro.

    W. J. Spain;P. C. Schwindt;W. E. Crill

  • Antiepileptic Drug-Induced Bone Loss in Young Male Patients Who Have Seizures

    Dennis L. Andress;Judy Ozuna;David Tirschwell;Lucinda Grande

  • Synaptic depression in the localization of sound.

    Daniel L. Cook;Peter C. Schwindt;Lucinda A. Grande;William J. Spain

  • In vitro analysis of optimal stimuli for phase-locking and time-delayed modulation of firing in avian nucleus laminaris neurons.

    A. D. Reyes;E. W. Rubel;W. J. Spain

  • Membrane properties underlying the firing of neurons in the avian cochlear nucleus

    AD Reyes;EW Rubel;WJ Spain

  • Diversity of Gain Modulation by Noise in Neocortical Neurons: Regulation by the Slow Afterhyperpolarization Conductance

    Matthew H. Higgs;Sean J. Slee;William J. Spain

  • Calcium-dependent potassium currents in neurons from cat sensorimotor cortex.

    P. C. Schwindt;W. J. Spain;W. E. Crill

  • Conditional bursting enhances resonant firing in neocortical layer 2-3 pyramidal neurons.

    Matthew H. Higgs;William J. Spain

  • Two transient potassium currents in layer V pyramidal neurones from cat sensorimotor cortex.

    W J Spain;P C Schwindt;W E Crill

  • Kv1 channels control spike threshold dynamics and spike timing in cortical pyramidal neurones

    Matthew H. Higgs;Matthew H. Higgs;William J. Spain;William J. Spain

  • Functional Roles of Kv1 Channels in Neocortical Pyramidal Neurons

    Dongxu Guan;Jonathan cf Lee;Matthew h Higgs;William J. Spain

  • Effects of intracellular calcium chelation on voltage-dependent and calcium-dependent currents in cat neocortical neurons.

    P.C. Schwindt;W.J. Spain;W.E. Crill

  • Two-dimensional time coding in the auditory brainstem.

    Sean J. Slee;Matthew H. Higgs;Adrienne L. Fairhall;William J. Spain

  • Differences in inhibitory synaptic input between layer II-III and layer V neurons of the cat neocortex

    J. F M Van Brederode;W. J. Spain

  • Erratum: Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy (Nature Neuroscience (2006) 9, (1142-1149))

    Frank H. Yu;Massimo Mantegazza;Ruth E. Westenbroek;Carol A. Robbins

Frequent Co-Authors

Peter C. Schwindt
Peter C. Schwindt University of Washington
Wayne E. Crill
Wayne E. Crill University of Washington
Robert C. Foehring
Robert C. Foehring University of Tennessee Health Science Center
Adrienne L. Fairhall
Adrienne L. Fairhall University of Washington
George B. Richerson
George B. Richerson University of Iowa
Jonathan T. Ting
Jonathan T. Ting Allen Institute for Brain Science
Alex D. Reyes
Alex D. Reyes New York University
Steven A. McCarroll
Steven A. McCarroll Harvard University
Bing Ren
Bing Ren New York Genome Center

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