D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 46 Citations 7,001 135 World Ranking 15296 National Ranking 279

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Apoptosis
  • Signal transduction

Cell biology, Sphingosine, Biochemistry, Lipid signaling and Ceramide are her primary areas of study. Andrea Huwiler usually deals with Cell biology and limits it to topics linked to Regulation of gene expression and Angiogenesis. Andrea Huwiler is studying Sphingosine-1-phosphate, which is a component of Sphingosine.

Her work is dedicated to discovering how Sphingosine-1-phosphate, Cancer research are connected with Epidermal growth factor, Transforming growth factor and MAPK cascade and other disciplines. In her work, Molecular biology and Protein kinase A is strongly intertwined with Protein kinase C, which is a subfield of Lipid signaling. Her Ceramide study deals with Sphingolipid intersecting with ASK1, Pathophysiology, Sphingolipid metabolism and Glycosphingolipid.

Her most cited work include:

  • Physiology and pathophysiology of sphingolipid metabolism and signaling. (404 citations)
  • Amplification of IL-1β-Induced Matrix Metalloproteinase-9 Expression by Superoxide in Rat Glomerular Mesangial Cells Is Mediated by Increased Activities of NF-κB and Activating Protein-1 and Involves Activation of the Mitogen-Activated Protein Kinase Pathways (191 citations)
  • Protein Kinase Cα-dependent Phosphorylation of the mRNA-stabilizing Factor HuR: Implications for Posttranscriptional Regulation of Cyclooxygenase-2 (165 citations)

What are the main themes of her work throughout her whole career to date?

Andrea Huwiler mainly investigates Cell biology, Sphingosine, Sphingosine-1-phosphate, Biochemistry and Kinase. Her work carried out in the field of Cell biology brings together such families of science as Mesangial cell, Ceramide and Lipid signaling. Her Sphingosine research integrates issues from Endocrinology and Downregulation and upregulation.

Her studies deal with areas such as Endothelial stem cell, Cancer research and Fingolimod as well as Sphingosine-1-phosphate. Her study looks at the relationship between Kinase and topics such as Phosphorylation, which overlap with Angiotensin II. Her Protein kinase C research includes elements of Tumor necrosis factor alpha and Protein kinase A.

She most often published in these fields:

  • Cell biology (61.90%)
  • Sphingosine (41.50%)
  • Sphingosine-1-phosphate (36.05%)

What were the highlights of her more recent work (between 2014-2021)?

  • Sphingosine-1-phosphate (36.05%)
  • Cell biology (61.90%)
  • Sphingosine (41.50%)

In recent papers she was focusing on the following fields of study:

Her scientific interests lie mostly in Sphingosine-1-phosphate, Cell biology, Sphingosine, Pharmacology and Receptor. Her research in Sphingosine-1-phosphate intersects with topics in Endocrinology, AMPK and Lipid signaling. Andrea Huwiler does research in Cell biology, focusing on Kinase specifically.

Her research integrates issues of Protein kinase B and Phosphorylation in her study of Kinase. Her Sphingosine research includes themes of Downregulation and upregulation, Kidney, Renal fibrosis and CTGF. As part of the same scientific family, she usually focuses on Receptor, concentrating on Cancer research and intersecting with Immunology.

Between 2014 and 2021, her most popular works were:

  • The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives. (86 citations)
  • Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo (38 citations)
  • Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases. (37 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Apoptosis
  • Signal transduction

Her primary scientific interests are in Sphingosine, Receptor, Sphingosine-1-phosphate, Cell biology and Internal medicine. Her Sphingosine study integrates concerns from other disciplines, such as Inflammation and Kidney. Her Receptor research incorporates themes from Fingolimod, Downregulation and upregulation, Pharmacology and Cancer research.

Her study with Sphingosine-1-phosphate involves better knowledge in Biochemistry. Her Cell biology study combines topics in areas such as Tumor necrosis factor alpha, Jurkat cells, Cell migration, CD44 and Soluble cell adhesion molecules. Within one scientific family, Andrea Huwiler focuses on topics pertaining to Kinase under Whole blood, and may sometimes address concerns connected to Sphingosine kinase 1.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Physiology and pathophysiology of sphingolipid metabolism and signaling.

Andrea Huwiler;Thomas Kolter;Josef Pfeilschifter;Konrad Sandhoff.
Biochimica et Biophysica Acta (2000)

550 Citations

Amplification of IL-1β-Induced Matrix Metalloproteinase-9 Expression by Superoxide in Rat Glomerular Mesangial Cells Is Mediated by Increased Activities of NF-κB and Activating Protein-1 and Involves Activation of the Mitogen-Activated Protein Kinase Pathways

Wolfgang Eberhardt;Andrea Huwiler;Karl-Friedrich Beck;Sebastian Walpen.
Journal of Immunology (2000)

293 Citations

Inducible NO synthase: role in cellular signalling.

K.F. Beck;W. Eberhardt;S. Frank;A. Huwiler.
The Journal of Experimental Biology (1999)

232 Citations

Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase Cδ Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA

Anke Doller;El-Sayed Akool;Andrea Huwiler;Roswitha Müller.
Molecular and Cellular Biology (2008)

224 Citations

Protein Kinase Cα-dependent Phosphorylation of the mRNA-stabilizing Factor HuR: Implications for Posttranscriptional Regulation of Cyclooxygenase-2

Anke Doller;Andrea Huwiler;Roswitha Müller;Heinfried H. Radeke.
Molecular Biology of the Cell (2007)

217 Citations

Sphingosine 1-Phosphate Cross-activates the Smad Signaling Cascade and Mimics Transforming Growth Factor-β-induced Cell Responses

Cuiyan Xin;Shuyu Ren;Burkhardt Kleuser;Soheyla Shabahang.
Journal of Biological Chemistry (2004)

199 Citations

Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells.

Andrea Huwiler;Andrea Huwiler;Josef Pfeilschifter;Henk van den Bosch.
Journal of Biological Chemistry (1999)

194 Citations

Dual Effect of Ceramide on Human Endothelial Cells Induction of Oxidative Stress and Transcriptional Upregulation of Endothelial Nitric Oxide Synthase

Huige Li;Peter Junk;Andrea Huwiler;Christian Burkhardt.
Circulation (2002)

188 Citations

The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia.

Bozena Czech;Waltraud Pfeilschifter;Waltraud Pfeilschifter;Niloufar Mazaheri-Omrani;Marc André Strobel.
Biochemical and Biophysical Research Communications (2009)

173 Citations

The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives.

Andrea Huwiler;Uwe Zangemeister-Wittke.
Pharmacology & Therapeutics (2018)

161 Citations

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