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D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
9734
World Ranking
14021
National Ranking
257

Overview

Andrea Huwiler is affiliated with the University of Bern in Switzerland. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions also in the field of medicine. Their work encompasses various subfields including molecular biology, cell biology, physiology, pharmacology, and organic chemistry.

The main topics of their scientific investigation involve sphingolipid metabolism and signaling, endoplasmic reticulum stress and disease, lipid membrane structure and behavior, circadian rhythm and melatonin, renal diseases and glomerulopathies, erythrocyte function and pathophysiology, and inflammatory mediators and NSAID effects.

Andrea Huwiler has published extensively in several scientific journals. Frequent publication venues include the International Journal of Molecular Sciences, Biomolecules, Journal of Lipid Research, Neuropharmacology, and Matrix Biology. The International Journal of Molecular Sciences has published the highest number of their papers.

Key recent publications include:

  • Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt, 2020, International Journal of Molecular Sciences
  • Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis, 2021, Neuropharmacology
  • Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice, 2021, Matrix Biology
  • The sphingosine kinase 2 inhibitors ABC294640 and K145 elevate (dihydro)sphingosine 1-phosphate levels in various cells, 2024, Journal of Lipid Research
  • Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge, 2020, International Journal of Molecular Sciences

Frequent coauthors collaborating with Andrea Huwiler include:

  • Josef Pfeilschifter
  • Stephanie Schwalm
  • Bisera Stepanovska Tanturovska
  • Faik Imeri
  • Burkhard Kleuser

Best Publications

  • Physiology and pathophysiology of sphingolipid metabolism and signaling.

    Andrea Huwiler;Thomas Kolter;Josef Pfeilschifter;Konrad Sandhoff

  • Amplification of IL-1β-Induced Matrix Metalloproteinase-9 Expression by Superoxide in Rat Glomerular Mesangial Cells Is Mediated by Increased Activities of NF-κB and Activating Protein-1 and Involves Activation of the Mitogen-Activated Protein Kinase Pathways

    Wolfgang Eberhardt;Andrea Huwiler;Karl-Friedrich Beck;Sebastian Walpen

  • Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.

    A Huwiler;J Brunner;R Hummel;M Vervoordeldonk

  • Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase Cδ Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA

    Anke Doller;El-Sayed Akool;Andrea Huwiler;Roswitha Müller

  • Protein Kinase Cα-dependent Phosphorylation of the mRNA-stabilizing Factor HuR: Implications for Posttranscriptional Regulation of Cyclooxygenase-2

    Anke Doller;Andrea Huwiler;Roswitha Müller;Heinfried H. Radeke

  • Inducible NO synthase: role in cellular signalling.

    K.F. Beck;W. Eberhardt;S. Frank;A. Huwiler

  • The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives.

    Andrea Huwiler;Uwe Zangemeister-Wittke

  • Sphingosine 1-Phosphate Cross-activates the Smad Signaling Cascade and Mimics Transforming Growth Factor-β-induced Cell Responses

    Cuiyan Xin;Shuyu Ren;Burkhardt Kleuser;Soheyla Shabahang

  • Dual Effect of Ceramide on Human Endothelial Cells Induction of Oxidative Stress and Transcriptional Upregulation of Endothelial Nitric Oxide Synthase

    Huige Li;Peter Junk;Andrea Huwiler;Christian Burkhardt

  • Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells.

    Andrea Huwiler;Andrea Huwiler;Josef Pfeilschifter;Henk van den Bosch

  • The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia.

    Bozena Czech;Waltraud Pfeilschifter;Waltraud Pfeilschifter;Niloufar Mazaheri-Omrani;Marc André Strobel

  • SphK1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial Sepsis

    Padmam Puneet;Celestial T. Yap;Lingkai Wong;Lam Yulin

  • Selective ceramide binding to protein kinase C-alpha and -delta isoenzymes in renal mesangial cells.

    Andrea Huwiler;Doriano Fabbro;Josef Pfeilschifter

  • Platelet-derived growth factor and angiotensin II stimulate the mitogen-activated protein kinase cascade in renal mesangial cells: comparison of hypertrophic and hyperplastic agonists.

    A Huwiler;S Stabel;D Fabbro;J Pfeilschifter

  • Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release.

    Andrea Huwiler;Berit Johansen;Anita Skarstad;Josef Pfeilschifter

  • Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat renal mesangial cells.

    Andrea Huwiler;Josef Pfeilschifter

  • New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets

    Andrea Huwiler;Josef Pfeilschifter

  • The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.

    Frauke Döll;Josef Pfeilschifter;Andrea Huwiler

  • Activation of protein kinase C subtypes α, γ, δ, ϵ, ζ, and η by tumor-promoting and nontumor-promoting agents

    Detlef Geiges;Thomas Meyer;Barbara Marte;Mirka Vanek

  • Cross-talk between secretory phospholipase A2 and cytosolic phospholipase A2 in rat renal mesangial cells

    Andrea Huwiler;Georgia Staudt;Ruth M Kramer;Josef Pfeilschifter;Josef Pfeilschifter

Frequent Co-Authors

Josef Pfeilschifter
Josef Pfeilschifter Goethe University Frankfurt
Uwe Zangemeister-Wittke
Uwe Zangemeister-Wittke University of Bern
Britta Engelhardt
Britta Engelhardt University of Bern
Doriano Fabbro
Doriano Fabbro Novartis (Switzerland)
Liliana Schaefer
Liliana Schaefer Goethe University Frankfurt
George Kokotos
George Kokotos National and Kapodistrian University of Athens
Stephen Hanessian
Stephen Hanessian University of Montreal
Gerd Geisslinger
Gerd Geisslinger Goethe University Frankfurt
Ralf P. Brandes
Ralf P. Brandes Goethe University Frankfurt
Thierry Levade
Thierry Levade Paul Sabatier University

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