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Uwe Zangemeister-Wittke

Uwe Zangemeister-Wittke

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
9378
World Ranking
14613
National Ranking
268

Overview

Uwe Zangemeister-Wittke is affiliated with the University of Bern in Switzerland. Their research spans the fields of biochemistry, genetics, and molecular biology, with a particular focus also on medicine. Within these fields, their work covers several subfields including molecular biology, radiology, nuclear medicine and imaging, and oncology.

The scientist's main research topics include:

  • Monoclonal and Polyclonal Antibodies Research
  • PI3K/AKT/mTOR signaling in cancer
  • HER2/EGFR in Cancer Research
  • Radiopharmaceutical Chemistry and Applications
  • Sphingolipid Metabolism and Signaling
  • Protein Kinase Regulation and GTPase Signaling
  • Protein purification and stability

Zangemeister-Wittke has published papers in several scientific journals, including:

  • Journal of Controlled Release
  • International Journal of Molecular Sciences
  • European Journal of Pharmaceutics and Biopharmaceutics
  • Clinical Cancer Research

Notable recent publications include:

  • Optimizing the anti-tumor efficacy of protein-drug conjugates by engineering the molecular size and half-life (2020), Journal of Controlled Release
  • Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt (2020), International Journal of Molecular Sciences
  • Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling (2021), European Journal of Pharmaceutics and Biopharmaceutics
  • Correction: Targeting the Phosphoinositide 3-Kinase p110-α Isoform Impairs Cell Proliferation, Survival, and Tumor Growth in Small Cell Lung Cancer (2025), Clinical Cancer Research

Frequent co-authors collaborating with Zangemeister-Wittke include:

  • Fabian Brandl
  • Andreas Plückthun
  • Sarah D. Busslinger
  • Stephanie Schwalm
  • Martin Erhardt

Best Publications

  • A Novel Antisense Oligonucleotide Targeting Survivin Expression Induces Apoptosis and Sensitizes Lung Cancer Cells to Chemotherapy

    R A Olie;A P Simões-Wüst;B Baumann;S H Leech

  • Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation

    Sally Hopkins-Donaldson;Annmarie Ziegler;S. Kurtz;C. Bigosch

  • Induction of Apoptosis in Small-Cell Lung Cancer Cells by an Antisense Oligodeoxynucleotide Targeting the Bcl-2 Coding Sequence

    Annemarie Ziegler;Gerd H. Luedke;Doriano Fabbro;Karl Heinz Altmann

  • High thermal stability is essential for tumor targeting of antibody fragments: engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment.

    J Willuda;A Honegger;R Waibel;P A Schubiger

  • Circulating DNA: a new diagnostic gold mine?

    Annemarie Ziegler;Uwe Zangemeister-Wittke;Rolf A Stahel

  • Antisense therapy for cancer—the time of truth

    Burkhard Jansen;Uwe Zangemeister-Wittke

  • Inflammation-associated Cell Cycle–independent Block of Apoptosis by Survivin in Terminally Differentiated Neutrophils

    Frank Altznauer;Sibylla Martinelli;Shida Yousefi;Christine Thürig

  • Activity of a Novel bcl-2/bcl-xL-Bispecific Antisense Oligonucleotide Against Tumors of Diverse Histologic Origins

    Oliver Gautschi;Stefan Tschopp;Robert A. Olie;Siân H. Leech

  • The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives.

    Andrea Huwiler;Uwe Zangemeister-Wittke

  • A Novel Bispecific Antisense Oligonucleotide Inhibiting Both bcl-2 and bcl-xL Expression Efficiently Induces Apoptosis in Tumor Cells

    U Zangemeister-Wittke;S H Leech;R A Olie;A P Simões-Wüst

  • Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines.

    U Zangemeister-Wittke;T Schenker;GH Luedke;RA Stahel

  • Role for Bcl-xL in Delayed Eosinophil Apoptosis Mediated by Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-5

    Birgit Dibbert;Isabelle Daigle;Doris Braun;Corinna Schranz

  • A recombinant immunotoxin derived from a humanized epithelial cell adhesion molecule-specific single-chain antibody fragment has potent and selective antitumor activity.

    Claudio Di Paolo;Jörg Willuda;Susanne Kubetzko;Ikar Lauffer

  • PEGylation and multimerization of the anti-p185HER-2 single chain Fv fragment 4D5: effects on tumor targeting.

    Susanne Kubetzko;Ela Balic;Robert Waibel;Uwe Zangemeister-Wittke

  • Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function.

    D Del Bufalo;A Rizzo;D Trisciuoglio;G Cardinali

  • DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency.

    Nikolas Stefan;Patricia Martin-Killias;Sascha Wyss-Stoeckle;Annemarie Honegger

  • Induction of apoptosis in lung-cancer cells following bcl-xL anti-sense treatment.

    Siân H. Leech;Robert A. Olie;Oliver Gautschi;A. Paula Simões‐Wüst

  • Tumor Targeting of Mono-, Di-, and Tetravalent Anti-p185HER-2 Miniantibodies Multimerized by Self-associating Peptides

    Jörg Willuda;Susanne Kubetzko;Robert Waibel;P. August Schubiger

  • Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation

    Larisa L. Belyanskaya;Sally Hopkins-Donaldson;Stefanie Kurtz;Ana Paula Simões-Wüst

  • Antitumor activity of an epithelial cell adhesion molecule targeted nanovesicular drug delivery system.

    Sajid Hussain;Andreas Plückthun;Theresa M. Allen;Uwe Zangemeister-Wittke

Frequent Co-Authors

Rolf A. Stahel
Rolf A. Stahel University of Zurich
Andreas Plückthun
Andreas Plückthun University of Zurich
Andrea Huwiler
Andrea Huwiler University of Bern
Hans-Uwe Simon
Hans-Uwe Simon University of Bern
Doriano Fabbro
Doriano Fabbro Novartis (Switzerland)
Gabriella Zupi
Gabriella Zupi École Normale Supérieure de Lyon
Martin E. Gleave
Martin E. Gleave University of British Columbia
Josef Pfeilschifter
Josef Pfeilschifter Goethe University Frankfurt
Robert Häner
Robert Häner University of Bern
Burkhard Jansen
Burkhard Jansen University of British Columbia

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