D-Index & Metrics Best Publications
Biology and Biochemistry
Canada
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 76 Citations 13,597 141 World Ranking 3230 National Ranking 98

Research.com Recognitions

Awards & Achievements

2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Amino acid

His main research concerns Mutant, Biochemistry, Transmembrane domain, P-glycoprotein and ATP-binding cassette transporter. David M. Clarke has included themes like Molecular biology, Endoplasmic reticulum, Cysteine and Stereochemistry in his Mutant study. His work is connected to ATPase, Binding site, Mutagenesis, Alanine and HEK 293 cells, as a part of Biochemistry.

His Transmembrane domain study contributes to a more complete understanding of Amino acid. As a member of one scientific family, David M. Clarke mostly works in the field of P-glycoprotein, focusing on Enzyme and, on occasion, Chromatography and Colchicine. His study looks at the intersection of ATP-binding cassette transporter and topics like Protein structure with Cell biology and Peptide sequence.

His most cited work include:

  • Location of high affinity Ca 2 + -binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca 2+ -ATPase (514 citations)
  • Membrane topology of a cysteine-less mutant of human P-glycoprotein. (241 citations)
  • Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators (217 citations)

What are the main themes of his work throughout his whole career to date?

David M. Clarke focuses on Biochemistry, Mutant, P-glycoprotein, Transmembrane domain and Molecular biology. His study in ATP-binding cassette transporter, ATPase, Binding site, Amino acid and ATP hydrolysis is carried out as part of his studies in Biochemistry. His study in Mutant is interdisciplinary in nature, drawing from both Mutation, Endoplasmic reticulum, Cell biology, Cysteine and Cystic fibrosis transmembrane conductance regulator.

His research investigates the link between P-glycoprotein and topics such as Stereochemistry that cross with problems in Cytoplasm. His Transmembrane domain research is multidisciplinary, relying on both Plasma protein binding, Biophysics, Protein folding, Peptide sequence and Mutant protein. His Molecular biology research includes elements of Homologous chromosome, Transfection, HEK 293 cells, Complementary DNA and Gene.

He most often published in these fields:

  • Biochemistry (59.57%)
  • Mutant (54.61%)
  • P-glycoprotein (39.01%)

What were the highlights of his more recent work (between 2009-2017)?

  • Mutant (54.61%)
  • P-glycoprotein (39.01%)
  • Transmembrane domain (36.17%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Mutant, P-glycoprotein, Transmembrane domain, Biochemistry and ATP-binding cassette transporter. His Mutant research includes themes of Mutation, ATP hydrolysis, Suppressor, Molecular biology and Cell biology. His Cell biology study combines topics in areas such as Folding and Genetics, Cystic fibrosis, Cystic fibrosis transmembrane conductance regulator.

The various areas that he examines in his P-glycoprotein study include Drug, Cytoplasm, Binding site and Protein folding. His Transmembrane domain research incorporates elements of Protein structure, Walker motifs and Homology. His ATP-binding cassette transporter research is multidisciplinary, incorporating elements of Biophysics, Stereochemistry, Membrane protein and Dithiothreitol.

Between 2009 and 2017, his most popular works were:

  • Predicting P-Glycoprotein-Mediated Drug Transport Based On Support Vector Machine and Three-Dimensional Crystal Structure of P-glycoprotein (96 citations)
  • Corrector VX-809 stabilizes the first transmembrane domain of CFTR (68 citations)
  • Human P-glycoprotein is active when the two halves are clamped together in the closed conformation. (55 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Amino acid

David M. Clarke mainly focuses on P-glycoprotein, Mutant, Transmembrane domain, Biochemistry and ATP-binding cassette transporter. His work carried out in the field of P-glycoprotein brings together such families of science as Homology modeling, Protein structure prediction, In silico and Computational biology. His Mutant study integrates concerns from other disciplines, such as Molecular biology, Biophysics and Binding site.

His Binding site research is multidisciplinary, incorporating perspectives in ATP hydrolysis, ATPase and Plasma protein binding. His studies in Transmembrane domain integrate themes in fields like Cytoplasm and Tariquidar. He performs multidisciplinary study in Biochemistry and Heteroatom in his work.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Location of high affinity Ca 2 + -binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca 2+ -ATPase

David M. Clarke;Tip W. Loo;Giuseppe Inesi;David H. MacLennan.
Nature (1989)

697 Citations

Membrane topology of a cysteine-less mutant of human P-glycoprotein.

Tip W. Loo;David M. Clarke.
Journal of Biological Chemistry (1995)

335 Citations

Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

T.W. Loo;D.M. Clarke.
The Journal of Membrane Biology (2005)

281 Citations

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

Tip W. Loo;David M. Clarke.
Journal of Biological Chemistry (1997)

277 Citations

Location of the Rhodamine-binding Site in the Human Multidrug Resistance P-glycoprotein

Tip W. Loo;David M. Clarke.
Journal of Biological Chemistry (2002)

255 Citations

Rapid Purification of Human P-glycoprotein Mutants Expressed Transiently in HEK 293 Cells by Nickel-Chelate Chromatography and Characterization of their Drug-stimulated ATPase Activities

Tip W. Loo;David M. Clarke.
Journal of Biological Chemistry (1995)

252 Citations

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers.

Tip W. Loo;David M. Clarke.
Journal of Biological Chemistry (2001)

251 Citations

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

Tip W. Loo;David M. Clarke.
Journal of Biological Chemistry (2001)

246 Citations

Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein.

Tip W. Loo;M.Claire Bartlett;David M. Clarke.
Journal of Biological Chemistry (2003)

233 Citations

Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.

Tip W. Loo;M. Claire Bartlett;David M. Clarke.
Journal of Biological Chemistry (2003)

232 Citations

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