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David M. Clarke

David M. Clarke

University of Toronto
Canada

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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
14072
World Ranking
4661
National Ranking
159

David M. Clarke publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where David M. Clarke sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 142 publications — 23rd percentile

23% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

David M. Clarke D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where David M. Clarke sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 78 D-Index — 77th percentile

77% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

David M. Clarke is affiliated with the University of Toronto in Canada.

Best Publications

  • Location of high affinity Ca 2 + -binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca 2+ -ATPase

    David M. Clarke;Tip W. Loo;Giuseppe Inesi;David H. MacLennan

  • Membrane topology of a cysteine-less mutant of human P-glycoprotein.

    Tip W. Loo;David M. Clarke

  • Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

    T.W. Loo;D.M. Clarke

  • Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

    Tip W. Loo;David M. Clarke

  • Location of the Rhodamine-binding Site in the Human Multidrug Resistance P-glycoprotein

    Tip W. Loo;David M. Clarke

  • Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

    Tip W. Loo;David M. Clarke

  • Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers.

    Tip W. Loo;David M. Clarke

  • Rapid Purification of Human P-glycoprotein Mutants Expressed Transiently in HEK 293 Cells by Nickel-Chelate Chromatography and Characterization of their Drug-stimulated ATPase Activities

    Tip W. Loo;David M. Clarke

  • Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein.

    Tip W. Loo;M.Claire Bartlett;David M. Clarke

  • Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.

    Tip W. Loo;M. Claire Bartlett;David M. Clarke

  • Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides.

    T W Loo;D M Clarke

  • Covalent Modification of Human P-glycoprotein Mutants Containing a Single Cysteine in Either Nucleotide-binding Fold Abolishes Drug-stimulated ATPase Activity

    Tip W. Loo;David M. Clarke

  • The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence.

    Tip W. Loo;M. Claire Bartlett;David M. Clarke

  • Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein.

    T W Loo;D M Clarke

  • Functional consequences of alterations to polar amino acids located in the transmembrane domain of the Ca2(+)-ATPase of sarcoplasmic reticulum.

    D M Clarke;T W Loo;D H MacLennan

  • Functional consequences of glutamate, aspartate, glutamine, and asparagine mutations in the stalk sector of the Ca2+-ATPase of sarcoplasmic reticulum.

    D. M. Clarke;K. Maruyama;T. W. Loo;E. Leberer

  • Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein.

    Ying Wang;Tip W. Loo;M. Claire Bartlett;David M. Clarke

  • Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

    Tip W. Loo;David M. Clarke

  • Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

    Tip W. Loo;David M. Clarke

  • The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

    Tip W. Loo;David M. Clarke

Frequent Co-Authors

Tip W. Loo
Tip W. Loo University of Toronto
David H. MacLennan
David H. MacLennan University of Toronto
John R. Riordan
John R. Riordan University of North Carolina at Chapel Hill
Michael R. Detty
Michael R. Detty University at Buffalo, State University of New York
John W. Hanrahan
John W. Hanrahan McGill University
Junichi Fujii
Junichi Fujii Yamagata University
Gary E. Shull
Gary E. Shull University of Cincinnati Medical Center
Jens Peter Andersen
Jens Peter Andersen Aarhus University
Cameron Ackerley
Cameron Ackerley University of Toronto
Clifford A. Lingwood
Clifford A. Lingwood University of Toronto

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Related Online Degrees & Career Pathways

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Best Scientists Citing David M. Clarke

Jens Peter Andersen

Jens Peter Andersen

Aarhus University

Publications: 67

Suresh V. Ambudkar

Suresh V. Ambudkar

National Institutes of Health

Publications: 61

Bente Vilsen

Bente Vilsen

Aarhus University

Publications: 53

John R. Riordan

John R. Riordan

University of North Carolina at Chapel Hill

Publications: 39

Giuseppe Inesi

Giuseppe Inesi

University of Maryland, Baltimore

Publications: 39

Michael M. Gottesman

Michael M. Gottesman

National Institutes of Health

Publications: 38

Richard Callaghan

Richard Callaghan

Australian National University

Publications: 35

David H. MacLennan

David H. MacLennan

University of Toronto

Publications: 33

Christine E. Bear

Christine E. Bear

University of Toronto

Publications: 33

Frank Wuytack

Frank Wuytack

KU Leuven

Publications: 27

Luc Raeymaekers

Luc Raeymaekers

KU Leuven

Publications: 25

Chikashi Toyoshima

Chikashi Toyoshima

University of Tokyo

Publications: 25

Christopher F. Higgins

Christopher F. Higgins

Hammersmith Hospital

Publications: 23

Kazumitsu Ueda

Kazumitsu Ueda

Kyoto University

Publications: 23

John W. Hanrahan

John W. Hanrahan

McGill University

Publications: 22

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Gergely L. Lukacs

McGill University

Publications: 22

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