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Chikashi Toyoshima

Chikashi Toyoshima

D-Index & Metrics

Chemistry

D-Index
61
Citations
17077
World Ranking
9124
National Ranking
645

Research.com Recognitions

  • 2016 - Gregori Aminoff Prize, Royal Swedish Academy of Sciences for their fundamental contributions to understanding the structural basis for ATP-driven translocation of ions across membranes
  • 2005 - Member of the National Academy of Sciences

Overview

Chikashi Toyoshima is affiliated with the University of Tokyo in Japan and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research spans multiple subfields, including molecular biology, organic chemistry, endocrinology, diabetes and metabolism, pulmonary and respiratory medicine, and pharmacology.

The primary topics of Chikashi Toyoshima's work include:

  • Ion Transport and Channel Regulation
  • ATP Synthase and ATPases Research
  • Photosynthetic Processes and Mechanisms
  • Signaling Pathways in Disease
  • Lipid Membrane Structure and Behavior
  • Ion channel regulation and function
  • Chemical synthesis and alkaloids

Frequent publication venues for Toyoshima include:

  • Proceedings of the National Academy of Sciences
  • FEBS Letters
  • Nature Structural & Molecular Biology
  • Journal of the American Chemical Society
  • Journal of Biological Chemistry

Their recent papers illustrate a focus on ATPase enzymes and membrane protein structure. Selected publications include:

  • Binding of cardiotonic steroids to Na +,K +-ATPase in the E2P state, 2020, Proceedings of the National Academy of Sciences
  • The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes, 2021, Nature Structural & Molecular Biology
  • What ATP binding does to the Ca 2+ pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca 2+, 2020, Proceedings of the National Academy of Sciences
  • Structural Determination, Total Synthesis, and Biological Activity of Iezoside, a Highly Potent Ca2+-ATPase Inhibitor from the Marine Cyanobacterium Leptochromothrix valpauliae, 2022, Journal of the American Chemical Society
  • Cryoelectron microscopy of Na +,K +-ATPase in the two E2P states with and without cardiotonic steroids, 2022, Proceedings of the National Academy of Sciences

Some frequent co-authors who have collaborated with Toyoshima include:

  • R. Kanai
  • Flemming Cornelius
  • Bente Vilsen
  • Takaharu Sakuragi
  • Masahide Kikkawa

The scientist has been recognized with awards such as the Gregori Aminoff Prize from the Royal Swedish Academy of Sciences in 2016 for contributions to understanding ATP-driven ion translocation across membranes. They were also elected as a Member of the National Academy of Sciences in 2005.

Best Publications

  • Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution

    Chikashi Toyoshima;Masayoshi Nakasako;Masayoshi Nakasako;Hiromi Nomura;Haruo Ogawa

  • Structural changes in the calcium pump accompanying the dissociation of calcium

    Chikashi Toyoshima;Hiromi Nomura

  • Crystal structure of the sodium - potassium pump at 2.4 A resolution

    Takehiro Shinoda;Haruo Ogawa;Flemming Cornelius;Chikashi Toyoshima

  • Myosin subfragment-1 is sufficient to move actin filaments in vitro.

    Yoko Yano Toyoshima;Stephen J. Kron;Elizabeth M. McNally;Kenneth R. Niebling

  • Crystal structure of the calcium pump with a bound ATP analogue.

    Chikashi Toyoshima;Tatsuaki Mizutani

  • Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues

    Chikashi Toyoshima;Hiromi Nomura;Takeo Tsuda

  • Structural basis of ion pumping by Ca2+-ATPase of the sarcoplasmic reticulum.

    Chikashi Toyoshima;Giuseppe Inesi

  • Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain

    Haruo Ogawa;Takehiro Shinoda;Flemming Cornelius;Chikashi Toyoshima

  • Crystal structure of a Na + -bound Na + ,K + -ATPase preceding the E1P state

    Ryuta Kanai;Haruo Ogawa;Bente Vilsen;Flemming Cornelius

  • Structure of the calcium pump from sarcoplasmic reticulum at 8-Å resolution

    Peijun Zhang;Chikashi Toyoshima;Koji Yonekura;N. Michael Green

  • Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes

    Chikashi Toyoshima;Nigel Unwin

  • How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane.

    Chikashi Toyoshima

  • Structural role of countertransport revealed in Ca(2+) pump crystal structure in the absence of Ca(2+).

    Koji Obara;Naoyuki Miyashita;Cheng Xu;Itaru Toyoshima

  • Three-dimensional cryo-electron microscopy of the calcium ion pump in the sarcoplasmic reticulum membrane

    Chikashi Toyoshima;Hiroyuki Sasabe;David L. Stokes

  • Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state.

    Chikashi Toyoshima;Shiho Iwasawa;Haruo Ogawa;Ayami Hirata

  • Structural aspects of ion pumping by Ca2+-ATPase of sarcoplasmic reticulum

    Chikashi Toyoshima

  • Homology modeling of the cation binding sites of Na+K+-ATPase

    Haruo Ogawa;Chikashi Toyoshima

  • Electron crystallography of ultrathin 3D protein crystals: Atomic model with charges

    Koji Yonekura;Kazuyuki Kato;Mitsuo Ogasawara;Masahiro Tomita;Masahiro Tomita

  • Modeling of the inhibitory interaction of phospholamban with the Ca2+ ATPase

    Chikashi Toyoshima;Michio Asahi;Yuji Sugita;Reena Khanna

  • Contrast transfer for frozen-hydrated specimens: determination from pairs of defocused images.

    Chikashi Toyoshima;Nigel Unwin

  • Structural basis of ion pumping by Ca2+-ATPase

    Chikashi Toyoshima

  • Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state without oligomycin

    R. Kanai;H. Ogawa;B. Vilsen;F. Cornelius

Frequent Co-Authors

Yuji Sugita
Yuji Sugita RIKEN Center for Biosystems Dynamics Research
Giuseppe Inesi
Giuseppe Inesi University of Maryland, Baltimore
Bente Vilsen
Bente Vilsen Aarhus University
David A. Lewis
David A. Lewis University of Pittsburgh
Steven J. D. Karlish
Steven J. D. Karlish Weizmann Institute of Science
David H. MacLennan
David H. MacLennan University of Toronto
Tetsu Akiyama
Tetsu Akiyama University of Tokyo
Keiichi Namba
Keiichi Namba Osaka University
Shoichi Ishiura
Shoichi Ishiura University of Tokyo

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