World's Best Scientists 2026 revealed!
Steven J. D. Karlish

Steven J. D. Karlish

D-Index & Metrics

Chemistry

D-Index
61
Citations
12348
World Ranking
9307
National Ranking
66

Biology and Biochemistry

D-Index
61
Citations
12394
World Ranking
11424
National Ranking
108

Overview

Steven J. D. Karlish is affiliated with the Weizmann Institute of Science in Israel. Their research spans biochemistry, genetics, molecular biology, and medicine, with significant contributions in molecular biology and related subfields such as ophthalmology, neurology, cell biology, and nephrology.

Karlish's work extensively covers the study of ion transport and channel regulation, ion channel regulation and function, glaucoma and retinal disorders, as well as neurological disorders and treatments. Other notable topics include retinal diseases and treatments, ATP synthase and ATPase research, and endoplasmic reticulum stress and disease.

Frequent coauthors collaborating with Karlish include Adriana Katz, Sofia Ygberg, Evgeny E. Akkuratov, Rebecca J. Howard, and Fulya Taylan. These collaborations reflect a range of interdisciplinary research efforts.

Karlish's publications appear in several scientific venues, including:

  • Journal of Biological Chemistry
  • American Journal of Physiology-Cell Physiology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The 'Nephron journals/Nephron journals
  • Glia

Key recent papers authored or coauthored by Karlish include:

  • A missense mutation converts the Na+,K+-ATPase into an ion channel and causes therapy-resistant epilepsy, 2021, Journal of Biological Chemistry
  • A digoxin derivative that potently reduces intraocular pressure: efficacy and mechanism of action in different animal models, 2024, American Journal of Physiology-Cell Physiology
  • Active Conformations of Neuronal Na+,K+-ATPase isoforms and a Disease-Causing Mutant, 2025, bioRxiv (Cold Spring Harbor Laboratory)
  • Association of Familial Hyperkalemia and Hypertension with Proximal Renal Tubular Acidosis and Epileptic Seizures, 2023, The 'Nephron journals/Nephron journals
  • Glial Versus Neuronal Na+/K+-ATPase in Activity-Evoked K+ Clearance and Their Sensitivity to Elevated Extracellular K+, 2025, Glia

Best Publications

  • The Sodium Pump

    Unknown

  • Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions

    Yoram Shechter;Steven J. D. Karlish

  • Structure and mechanism of Na,K-ATPase: functional sites and their interactions

    Peter L Jorgensen;Kjell O Hakansson;Steven J D Karlish

  • Characterization of conformational changes in (Na,K) ATPase labeled with fluorescein at the active site.

    S. J. D. Karlish

  • Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties.

    Gilles Crambert;Maria Füzesi;Haim Garty;Steven Karlish

  • ROLE OF FXYD PROTEINS IN ION TRANSPORT

    Haim Garty;Steven J.D. Karlish

  • Tryptophan fluorescence of (Na+ + K+)-ATPase as a tool for study of the enzyme mechanism.

    S.J.D. Karlish;D.W. Yates

  • Conformational transitions between Na+-bound and K+-bound forms of (Na+ + K+)-ATPase, studied with formycin nucleotides.

    S.J.D. Karlish;D.W. Yates;I.M. Glynn

  • Electron paramagnetic resonance studies and insulin-like effects of vanadium in rat adipocytes.

    Hadassa Degani;Miriam Gochin;Steven J. D. Karlish;Yoram Shechter

  • Indications for an oligomeric structure and for conformational changes in sarcoplasmic reticulum Ca2+-ATPase labelled selectively with fluorescein.

    Uri Pick;Steven J.D. Karlish

  • Evidence for an interaction between adducin and Na+-K+-ATPase: relation to genetic hypertension

    Mara Ferrandi;Sergio Salardi;Grazia Tripodi;Paolo Barassi

  • Tissue-specific Distribution and Modulatory Role of the γ Subunit of the Na,K-ATPase

    Alex G. Therien;Rivka Goldshleger;Steven J.D. Karlish;Rhoda Blostein

  • Selectivity of Digitalis Glycosides for Isoforms of Human Na,K-ATPase

    Adriana Katz;Yael Lifshitz;Elizabeta Bab-Dinitz;Einat Kapri-Pardes

  • Expression and Functional Role of the γ Subunit of the Na,K-ATPase in Mammalian Cells

    Alex G. Therien;Steven J.D. Karlish;Rhoda Blostein

  • General and specific lipid-protein interactions in Na,K-ATPase.

    F. Cornelius;M. Habeck;R. Kanai;C. Toyoshima

  • Functional Role and Immunocytochemical Localization of the γa and γb Forms of the Na,K-ATPase γ Subunit

    Helen X. Pu;Francoise Cluzeaud;Rivka Goldshleger;Steven J.D. Karlish

  • Vanadate inhibits (Na+ + K+)ATPase by blocking a conformational change of the unphosphorylated form

    S. J. D. Karlish;L. A. Beaugé;I. M. Glynn

  • Extensive digestion of Na+,K(+)-ATPase by specific and nonspecific proteases with preservation of cation occlusion sites.

    Unknown

  • Interaction with the Na,K-ATPase and tissue distribution of FXYD5 (related to ion channel).

    Irina Lubarski;Kaarina Pihakaski-Maunsbach;Steven J.D. Karlish;Arvid B. Maunsbach

  • Kinetic parameters of glucose efflux from human red blood cells under zero-trans conditions.

    S.J.D. Karlish;W.R. Lieb;D. Ram;W.D. Stein

  • A Model for Active Transport of Sodium and Potassium Ions as Mediated by a Tetrameric Enzyme

    W. D. Stein;W. R. Lieb;S. J. D. Karlish;Y. Eilam

  • Evidence for the organization of the transmembrane segments of (Na,K)-ATPase based on labeling lipid-embedded and surface domains of the alpha-subunit.

    P L Jørgensen;S J Karlish;C Gitler

  • A 19-kDa C-terminal tryptic fragment of the alpha chain of Na/K-ATPase is essential for occlusion and transport of cations.

    Unknown

Frequent Co-Authors

Yoram Shechter
Yoram Shechter Weizmann Institute of Science
Mordhay Avron
Mordhay Avron Weizmann Institute of Science
George Sachs
George Sachs University of California, Los Angeles
Chikashi Toyoshima
Chikashi Toyoshima University of Tokyo
Shimon Amir
Shimon Amir Concordia University
Nicolette Farman
Nicolette Farman Centre de Recherche des Cordeliers
Käthi Geering
Käthi Geering University of Lausanne
Eitan Bibi
Eitan Bibi Weizmann Institute of Science
Bernhard Kuster
Bernhard Kuster Technical University of Munich
Alessio Cimmino
Alessio Cimmino University of Naples Federico II

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