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Biology and Biochemistry

D-Index
49
Citations
10706
World Ranking
17936
National Ranking
183

Overview

Yoram Shechter is affiliated with the Weizmann Institute of Science in Israel. Their research spans multiple domains within medicine and chemistry, focusing on areas such as inorganic chemistry, radiology, nuclear medicine, oncology, and statistical methods in clinical trials.

Their recent scholarly output includes studies published in the journal Pharmaceutics, contributing to its body of work with investigations into anti-proliferative agents and prodrug analogues targeting glioma cells. Specific papers include:

  • Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis (2021, Pharmaceutics)
  • Albumin-Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells (2021, Pharmaceutics)

The scientist frequently collaborates with several researchers, including:

  • Itzik Cooper
  • Mati Fridkin
  • Orly Ravid
  • Daniel Rand
  • Dana Atrakchi

Main topics of their research involve detailed studies in vanadium and halogenation chemistry, metal-catalyzed oxygenation mechanisms, metal complexes synthesis and properties, statistical methods in clinical trials, radiopharmaceutical chemistry and its applications, as well as monoclonal and polyclonal antibodies research.

  • Vanadium and Halogenation Chemistry
  • Metal-Catalyzed Oxygenation Mechanisms
  • Metal complexes synthesis and properties
  • Statistical Methods in Clinical Trials
  • Radiopharmaceutical Chemistry and Applications
  • Monoclonal and Polyclonal Antibodies Research

Their work intersects with subfields involving inorganic chemistry and radiology, nuclear medicine, and imaging techniques, reflecting a multidisciplinary approach linking chemical synthesis and clinical applications.

Yoram Shechter's contributions to medicine and chemistry have been documented primarily through journal articles rather than book publications. The recorded publications highlight a focus on novel therapeutic agents and methods that engage cellular entry mechanisms for glioma treatment.

Best Publications

  • Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells.

    Joseph Schlessinger;Yoram Shechter;Mark C. Willingham;Ira Pastan

  • Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions

    Yoram Shechter;Steven J. D. Karlish

  • Selective oxidation of methionine residues in proteins

    Yoram Shechter;Yigal Burstein;Abraham Patchornik

  • Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization

    Frederick R. Maxfield;Joseph Schlessinger;Joseph Schlessinger;Yoram Shechter;Ira Pastan

  • Historic perspective and recent developments on the insulin-like actions of vanadium; toward developing vanadium-based drugs for diabetes

    Yoram Shechter;Itzhak Goldwaser;Marina Mironchik;Mati Fridkin

  • Insulin receptor: covalent labeling and identification of subunits

    S Jacobs;E Hazum;Y Shechter;P Cuatrecasas

  • Electron paramagnetic resonance studies and insulin-like effects of vanadium in rat adipocytes.

    Hadassa Degani;Miriam Gochin;Steven J. D. Karlish;Yoram Shechter

  • Prolonging the action of protein and peptide drugs by a novel approach of reversible polyethylene glycol modification.

    Haim Tsubery;Marina Mironchik;Mati Fridkin;Yoram Shechter

  • Insulin-like effects of vanadium: basic and clinical implications.

    Itzhak Goldwaser;Dov Gefel;Eytan Gershonov;Mati Fridkin

  • Epidermal growth factor: Biological activity requires persistent occupation of high-affinity cell surface receptors

    Yoram Shechter;Lydia Hernaez;Pedro Cuatrecasas

  • Vanadium salts as insulin substitutes: mechanisms of action, a scientific and therapeutic tool in diabetes mellitus research.

    Natesampillai Sekar;Jinping Li;Yoram Shechter

  • Mobility, clustering, and transport of nerve growth factor in embryonal sensory cells and in a sympathetic neuronal cell line.

    Andrea Levi;Yoram Shechter;Ellis J. Neufeld;Joseph Schlessinger

  • Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts

    Joseph Schlessinger;Y. Shechter;P. Cuatrecasas;M. C. Willingham

  • Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin

    Yoram Shechter;Joseph Schlessinger;Steven Jacobs;Kwen-Jen Chang

  • Reversible PEGylation of peptide YY3-36 prolongs its inhibition of food intake in mice

    Yoram Shechter;Haim Tsubery;Marina Mironchik;Menachem Rubinstein

  • Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes.

    A Shisheva;Y Shechter

  • Reversible PEGylation: a novel technology to release native interferon alpha2 over a prolonged time period.

    Tal Peleg-Shulman;Haim Tsubery;Marina Mironchik;Mati Fridkin

  • Modulation of binding and bioactivity of insulin by anti-insulin antibody: relation to possible role of receptor self-aggregation in hormone action

    Yoram Shechter;Kwen-Jen Chang;Steven Jacobs;Pedro Cuatrecasas

  • Selective chemical cleavage of tryptophanyl peptide bonds by oxidative chlorination with N-chlorosuccinimide

    Yoram Shechter;Abraham Patchornik;Yigal Burstein

  • Vanadium activates or inhibits receptor and non-receptor protein tyrosine kinases in cell-free experiments, depending on its oxidation state. Possible role of endogenous vanadium in controlling cellular protein tyrosine kinase activity.

    G. Elberg;Jinping Li;Y. Shechter

Frequent Co-Authors

Mati Fridkin
Mati Fridkin Weizmann Institute of Science
Shimon Amir
Shimon Amir Concordia University
Irun R. Cohen
Irun R. Cohen Weizmann Institute of Science
Menachem Rubinstein
Menachem Rubinstein Weizmann Institute of Science
Steven J. D. Karlish
Steven J. D. Karlish Weizmann Institute of Science
Abraham Shanzer
Abraham Shanzer Weizmann Institute of Science
Pedro Cuatrecasas
Pedro Cuatrecasas Research Triangle Park Foundation
Joseph Schlessinger
Joseph Schlessinger Yale University
Arieh Gertler
Arieh Gertler Hebrew University of Jerusalem
Mark C. Willingham
Mark C. Willingham Wake Forest University

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