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Biology and Biochemistry

D-Index
128
Citations
51048
World Ranking
457
National Ranking
293

Overview

Michael P. Czech is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily focuses on medicine, with significant contributions to biochemistry, genetics, and molecular biology. The scientist has a substantial publication record in various fields, emphasizing physiology, epidemiology, biochemistry, cardiology, and molecular biology.

The main research topics of Michael P. Czech include:

  • Adipose Tissue and Metabolism
  • Adipokines, Inflammation, and Metabolic Diseases
  • Lipid metabolism and biosynthesis
  • Liver Disease Diagnosis and Treatment
  • Cardiovascular Disease and Adiposity
  • Autophagy in Disease and Therapy
  • Pancreatic function and diabetes

Frequent co-authors in collaborations are:

  • Mark Kelly
  • Adí́lson Guilherme
  • Batuhan Yenilmez
  • Lawrence M. Lifshitz
  • Leslie A. Rowland

Publication venues where Michael P. Czech has contributed the most include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Molecular Metabolism
  • Nature Communications
  • eLife

Selected recent papers authored or co-authored by Michael P. Czech are:

  • Mechanisms of insulin resistance related to white, beige, and brown adipocytes, 2020, Molecular Metabolism
  • Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis, 2020, Cell Reports
  • CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease, 2021, Nature Communications
  • Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration, 2020, Cell Reports
  • The adipocyte supersystem of insulin and cAMP signaling, 2022, Trends in Cell Biology

Best Publications

  • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

    Adilson Guilherme;Joseph V. Virbasius;Vishwajeet Puri;Michael P. Czech

  • The GLUT4 Glucose Transporter

    Shaohui Huang;Michael P. Czech

  • Insulin action and resistance in obesity and type 2 diabetes

    Michael P Czech

  • The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

    J Massagué;M P Czech

  • PIP2 and PIP3: complex roles at the cell surface.

    Michael P Czech

  • Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone

    Leanne Wilson-Fritch;Sarah M. Nicoloro;My T. Chouinard;Mitchell A. Lazar

  • SIGNALING MECHANISMS THAT REGULATE GLUCOSE TRANSPORT

    Michael P. Czech;Silvia Corvera

  • Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

    Shinya U. Amano;Jessica L. Cohen;Pranitha Vangala;Michaela Tencerova

  • A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

    Lucia E. Rameh;Ann Kristin Arvidsson;Kermit L Carraway;Anthony D. Couvillon

  • Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

    Myriam Aouadi;Gregory J. Tesz;Sarah M. Nicoloro;Mengxi Wang

  • Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

    P F Pilch;M P Czech

  • What causes the insulin resistance underlying obesity

    Olga T. Hardy;Michael P. Czech;Silvia Corvera

  • Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

    Zhen Y. Jiang;Qiong L. Zhou;Kerri A. Coleman;My T. Chouinard

  • Mitochondrial Biogenesis and Remodeling during Adipogenesis and in Response to the Insulin Sensitizer Rosiglitazone

    Leanne Wilson-Fritch;Alison Burkart;Gregory Bell;Karen Mendelson

  • Signal transmission by the insulin-like growth factors.

    Michael P. Czech

  • Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains.

    Jes K. Klarlund;Adilson Guilherme;John J. Holik;Joseph V. Virbasius

  • The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes.

    P F Pilch;M P Czech

  • A single receptor binds both insulin-like growth factor II and mannose-6-phosphate.

    Richard G. Macdonald;Suzanne R. Pfeffer;Lisa Coussens;Mark A. Tepper

  • FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

    Li Li;Jumin Zhou;Guy James;Robin Heller-Harrison

  • Molecular Basis of Insulin Action

    Michael P. Czech

Frequent Co-Authors

Silvia Corvera
Silvia Corvera University of Massachusetts Chan Medical School
Joan Massagué
Joan Massagué Memorial Sloan Kettering Cancer Center
Paul F. Pilch
Paul F. Pilch Boston University
Jason K. Kim
Jason K. Kim University of Massachusetts Chan Medical School
Andrew D. Cherniack
Andrew D. Cherniack Broad Institute
Roger J. Davis
Roger J. Davis University of Massachusetts Chan Medical School
John D. Leszyk
John D. Leszyk University of Massachusetts Chan Medical School
Kevin E. Fogarty
Kevin E. Fogarty University of Massachusetts Chan Medical School
John N. Fain
John N. Fain University of Tennessee Health Science Center
Sheila Collins
Sheila Collins Vanderbilt University Medical Center

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