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Geoffrey D. Holman

Geoffrey D. Holman

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
14789
World Ranking
9660
National Ranking
736

Overview

Geoffrey D. Holman is affiliated with the University of Bath in the United Kingdom. Their research focuses predominantly on biochemistry, genetics, and molecular biology with applications in medicine. The primary areas of study include molecular biology, physiology, and cell biology, reflecting a broad engagement with life sciences at the cellular and systemic levels.

The scientific contributions of Geoffrey D. Holman span several key topics related to metabolism and physiology. Notably, their work touches on metabolism, diabetes, and cancer; ion channel regulation and function; erythrocyte function and pathophysiology; adipose tissue and metabolism; as well as muscle metabolism and nutrition.

Their publication record includes papers in specialized journals such as Pflügers Archiv - European Journal of Physiology and Biomolecules. Recent papers include:

  • Structure, function and regulation of mammalian glucose transporters of the SLC2 family, 2020, Pflügers Archiv - European Journal of Physiology
  • Muscle-Specific Ablation of Glucose Transporter 1 (GLUT1) Does Not Impair Basal or Overload-Stimulated Skeletal Muscle Glucose Uptake, 2022, Biomolecules

Their frequent collaborators include researchers such as Shawna L. McMillin, Parker L. Evans, William M. Taylor, Luke A. Weyrauch, and Tyler J. Sermersheim, indicating active engagement with a diverse research community around metabolic and physiological sciences.

Best Publications

  • The glucose transporter family: structure, function and tissue-specific expression.

    G W Gould;G D Holman

  • Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin

    S Lund;G D Holman;O Schmitz;O Pedersen

  • Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

    Kei Sakamoto;Geoffrey D. Holman

  • Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin.

    J F Clarke;P W Young;K Yonezawa;M Kasuga

  • Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.

    G D Holman;I J Kozka;A E Clark;C J Flower

  • Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action

    S. Satoh;H. Nishimura;A.E. Clark;I.J. Kozka

  • Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited.

    Ian A. Simpson;Nathan M. Appel;Mitsuhiko Hokari;Jun Oki

  • Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells.

    J Yang;G D Holman

  • The human glomerular podocyte is a novel target for insulin action.

    Richard J M Coward;Gavin I Welsh;Jing Yang;Candida Tasman

  • 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes.

    Heikki A. Koistinen;Dana Galuska;Alexander V. Chibalin;Jing Yang

  • Insulin regulation of the two glucose transporters in 3T3-L1 adipocytes.

    D.M. Calderhead;K. Kitagawa;L.I. Tanner;G.D. Holman

  • Structural requirements for binding to the sugar-transport system of the human erythrocyte

    J. E. G. Barnett;G. D. Holman;K. A. Munday

  • The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults

    Enhad A Chowdhury;Judith D Richardson;Geoffrey D Holman;Kostas Tsintzas

  • Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients.

    J W Ryder;J Yang;D Galuska;J Rincón

  • Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle.

    Ji Li;Xiaoyue Hu;Pradeepa Selvakumar;Raymond R. Russell

  • From receptor to transporter: insulin signalling to glucose transport

    G. D. Holman;M. Kasuga

  • Chronic treatment with 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner

    Esben S. Buhl;Niels Jessen;Ole Schmitz;Steen B. Pedersen

  • Insulin-induced Recruitment of Glucose Transporter 4 (GLUT4) and GLUT1 in Isolated Rat Cardiac Myocytes EVIDENCE OF THE EXISTENCE OF DIFFERENT INTRACELLULAR GLUT4 VESICLE POPULATIONS

    Yvan Fischer;Julia Thomas;Lidia Sevilla;Purificación Muñoz

  • Evidence for two asymmetric conformational states in the human erythrocyte sugar-transport system.

    J E Barnett;G D Holman;R A Chalkley;K A Munday

  • Insulin-stimulated GLUT4 glucose transporter recycling. A problem in membrane protein subcellular trafficking through multiple pools.

    G.D. Holman;L. Lo Leggio;S.W. Cushman

Frequent Co-Authors

Samuel W. Cushman
Samuel W. Cushman National Institutes of Health
Juleen R. Zierath
Juleen R. Zierath Karolinska Institute
Oluf Pedersen
Oluf Pedersen University of Copenhagen
Masato Kasuga
Masato Kasuga National Center For Global Health and Medicine
Gwyn W. Gould
Gwyn W. Gould University of Strathclyde
Ian A. Simpson
Ian A. Simpson Pennsylvania State University
Ole Schmitz
Ole Schmitz Aarhus University Hospital
David E. James
David E. James University of Sydney
Takashi Kadowaki
Takashi Kadowaki Toranomon Hospital
Stephen A. Baldwin
Stephen A. Baldwin University of Leeds

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