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Biology and Biochemistry

D-Index
62
Citations
15476
World Ranking
10689
National Ranking
274

Overview

Harold Tjalsma is affiliated with Radboud University in the Netherlands. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Pharmacology, Toxicology and Pharmaceutics.

Their scientific work focuses on several key topics including:

  • Pharmacogenetics and Drug Metabolism
  • Inflammatory mediators and NSAID effects
  • Colorectal Cancer Screening and Detection
  • Enzyme Production and Characterization
  • Enzyme Catalysis and Immobilization

Harold Tjalsma has contributed to several subfields such as Pharmacology, Oncology, Biotechnology, and Molecular Biology.

Their recent publications include the paper titled Streptococcus gallolyticus Increases Expression and Activity of Aryl Hydrocarbon Receptor-Dependent CYP1 Biotransformation Capacity in Colorectal Epithelial Cells, published in 2021 in the journal Frontiers in Cellular and Infection Microbiology. This work has been cited 19 times to date.

Frequent collaborators in their work include:

  • Rahwa Taddese
  • Rian Roelofs
  • Derk Draper
  • Xinqun Wu
  • Shaoguang Wu

Their publications have appeared primarily in the journal Frontiers in Cellular and Infection Microbiology.

In addition to journal articles, Harold Tjalsma has contributed to book publications. Notably, they have authored a section in the Handbook of Proteolytic Enzymes, published by Elsevier BV in 2025, which has accrued 10 citations.

Best Publications

  • Signal Peptide-Dependent Protein Transport in Bacillus subtilis : a Genome-Based Survey of the Secretome

    Harold Tjalsma;Albert Bolhuis;Jan D. H. Jongbloed;Sierd Bron

  • A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects.

    Harold Tjalsma;Annemarie Boleij;Julian Roberto Marchesi;Bas E. Dutilh

  • Proteomics of Protein Secretion by Bacillus subtilis: Separating the “Secrets” of the Secretome

    H Tjalsma;H. Antelmann;Jan Jongbloed;Peter Braun

  • Towards the Human Colorectal Cancer Microbiome

    Julian R. Marchesi;Bas E. Dutilh;Bas E. Dutilh;Neil Hall;Wilbert H. M. Peters

  • Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants

    Tanja Jaeggi;Guus A M Kortman;Diego Moretti;Christophe Chassard

  • Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women.

    Diego Moretti;Jeroen S. Goede;Christophe Zeder;Markus Jiskra

  • Hepcidin: from discovery to differential diagnosis

    Erwin H J M Kemna;Harold Tjalsma;Hans L Willems;Dorine W Swinkels

  • A Proteomic View on Genome-Based Signal Peptide Predictions

    Haike Antelmann;Harold Tjalsma;Birgit Voigt;Steffen Ohlmeier

  • Clinical Importance of Streptococcus gallolyticus Infection Among Colorectal Cancer Patients: Systematic Review and Meta-analysis

    Annemarie Boleij;Marleen M. H. J. van Gelder;Dorine W. Swinkels;Harold Tjalsma

  • Hepcidin in Human Iron Disorders: Diagnostic Implications

    Joyce J.C. Kroot;Harold Tjalsma;Robert E. Fleming;Dorine W. Swinkels

  • Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications.

    Erwin H.J.M. Kemna;Harold Tjalsma;Vladimir N. Podust;Dorine W. Swinkels

  • Nutritional iron turned inside out: intestinal stress from a gut microbial perspective

    Guus A.M. Kortman;Manuela Raffatellu;Dorine W. Swinkels;Harold Tjalsma

  • Advances in quantitative hepcidin measurements by time-of-flight mass spectrometry.

    Dorine W. Swinkels;Domenico Girelli;Coby Laarakkers;Joyce Kroot

  • Immunochemical and Mass-Spectrometry–Based Serum Hepcidin Assays for Iron Metabolism Disorders

    Joyce J.C. Kroot;Coby M.M. Laarakkers;Anneke J. Geurts-Moespot;Nicolaï Grebenchtchikov

  • Iron availability increases the pathogenic potential of Salmonella typhimurium and other enteric pathogens at the intestinal epithelial interface.

    Guus A. M. Kortman;Annemarie Boleij;Dorine W. Swinkels;Harold Tjalsma

  • Functional analysis of the secretory precursor processing machinery of Bacillus subtilis: identification of a eubacterial homolog of archaeal and eukaryotic signal peptidases

    Harold Tjalsma;Albert Bolhuis;Maarten L. van Roosmalen;Thomas Wiegert

  • Type I signal peptidases of Gram-positive bacteria

    Maarten L. van Roosmalen;Nick Geukens;Jan D.H. Jongbloed;Harold Tjalsma

  • TatC Is a Specificity Determinant for Protein Secretion via the Twin-arginine Translocation Pathway

    Jan D.H. Jongbloed;Ulrike Martin;Haike Antelmann;Michael Hecker

  • Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation

    Felix Bohne;Marc Martínez-Llordella;Juan-José Lozano;Rosa Miquel

  • Bacillus subtilis contains four closely related type I signal peptidases with overlapping substrate specificities - Constitutive and temporally controlled expression of different sip genes

    Harold Tjalsma;Michiel A. Noback;Sierd Bron;Gerard Venema

Frequent Co-Authors

Dorine W. Swinkels
Dorine W. Swinkels Radboud University
Sierd Bron
Sierd Bron University of Groningen
Jan Maarten van Dijl
Jan Maarten van Dijl University Medical Center Groningen
Bas E. Dutilh
Bas E. Dutilh Utrecht University
Wim J. Quax
Wim J. Quax University of Groningen
Michael Hecker
Michael Hecker University of Greifswald
Gerhardus Venema
Gerhardus Venema University of Groningen
Haike Antelmann
Haike Antelmann Freie Universität Berlin
Girbe Buist
Girbe Buist University Medical Center Groningen

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