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D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
16916
World Ranking
4885
National Ranking
2344

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Peter Arvan is affiliated with the University of Michigan-Ann Arbor in the United States. Their research focuses primarily on fields within biochemistry, genetics, and molecular biology, combined extensively with medicine. The scientist's work spans multiple subfields including surgery, cell biology, molecular biology, genetics, and endocrinology, diabetes, and metabolism.

Their research addresses major scientific topics such as pancreatic function and diabetes, endoplasmic reticulum stress and disease, diabetes and associated disorders, metabolism in relation to diabetes and cancer, thyroid disorders and treatments, autophagy in disease and therapy, and erythrocyte function and pathophysiology.

Some of their recent published papers include:

  • Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus (2021), Nature Reviews Endocrinology
  • GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer (2020), Nature Communications
  • Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence (2021), Frontiers in Endocrinology
  • Adaptation to chronic ER stress enforces pancreatic β-cell plasticity (2022), Nature Communications
  • Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling (2020), Journal of Clinical Investigation

Peter Arvan's frequent co-authors include Leena Haataja, Anoop Arunagiri, Ming Liu, Billy Tsai, and Randal J. Kaufman, reflecting collaborative research partnerships.

The scientist regularly publishes in several venues, with the largest number of publications appearing in the journal Diabetes. Other significant publication platforms include bioRxiv (Cold Spring Harbor Laboratory), Journal of Clinical Investigation, Journal of Biological Chemistry, and Nature Communications.

Among awarded distinctions, Peter Arvan is recognized as a Member of the Association of American Physicians.

Best Publications

  • Sorting and storage during secretory granule biogenesis: looking backward and looking forward.

    Peter Arvan;David Castle

  • Controlled Induction of Human Pancreatic Progenitors Produces Functional Beta-Like Cells

    Matthias Hebrok;Holger Andreas Russ

  • Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

    Tamara J. Nicolson;Elisa A. Bellomo;Nadeeja Wijesekara;Merewyn K. Loder

  • Mannose 6–Phosphate Receptors Are Sorted from Immature Secretory Granules via Adaptor Protein AP-1, Clathrin, and Syntaxin 6–positive Vesicles

    Judith Klumperman;Regina Kuliawat;Janice M. Griffith;Hans J. Geuze

  • Endocrinopathies in the Family of Endoplasmic Reticulum (ER) Storage Diseases: Disorders of Protein Trafficking and the Role of ER Molecular Chaperones*

    Paul S. Kim;Peter Arvan

  • How Does Type 1 Diabetes Develop?: The Notion of Homicide or β-Cell Suicide Revisited

    Mark A. Atkinson;Jeffrey A. Bluestone;George S. Eisenbarth;Matthias Hebrok

  • Calnexin and BiP act as sequential molecular chaperones during thyroglobulin folding in the endoplasmic reticulum.

    P S Kim;P Arvan

  • Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus

    Carlo Colombo;Ottavia Porzio;Ming Liu;Ornella Massa

  • Secretory pathway quality control operating in Golgi, plasmalemmal, and endosomal systems.

    Peter Arvan;Xiang Zhao;Jose Ramos-Castaneda;Amy Chang

  • Insulin demand regulates β cell number via the unfolded protein response

    Rohit B. Sharma;Amy C. O’Donnell;Rachel E. Stamateris;Binh Ha

  • Protein targeting via the "constitutive-like" secretory pathway in isolated pancreatic islets: passive sorting in the immature granule compartment.

    R Kuliawat;P Arvan

  • Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

    Ming Liu;Israel Hodish;Leena Haataja;Roberto Lara-Lemus

  • Differential Sorting of Lysosomal Enzymes Out of the Regulated Secretory Pathway in Pancreatic β-Cells

    Regina Kuliawat;Judith Klumperman;Thomas Ludwig;Peter Arvan

  • Proinsulin maturation, misfolding, and proteotoxicity

    Ming Liu;Israel Hodish;Christopher J. Rhodes;Peter Arvan

  • Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response.

    Xing Huang Gao;Dawid Krokowski;Bo Jhih Guan;Ilya Bederman

  • Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility.

    Xue Fen Huang;Peter Arvan

  • Caveolin-1 Binding to Endoplasmic Reticulum Membranes and Entry into the Regulated Secretory Pathway Are Regulated by Serine Phosphorylation: PROTEIN SORTING AT THE LEVEL OF THE ENDOPLASMIC RETICULUM

    Amnon Schlegel;Peter Arvan;Michael P. Lisanti

  • Distinct molecular mechanisms for protein sorting within immature secretory granules of pancreatic beta-cells.

    R Kuliawat;P Arvan

  • Ca++-induced fusion of proteoliposomes: Dependence on transmembrane osmotic gradient

    Christopher Miller;Peter Arvan;John N. Telford;Efraim Racker

  • Congenital hypothyroid goiter with deficient thyroglobulin. Identification of an endoplasmic reticulum storage disease with induction of molecular chaperones.

    G Medeiros-Neto;P S Kim;S E Yoo;J Vono

Frequent Co-Authors

Christopher J. Rhodes
Christopher J. Rhodes University of Chicago
Karl E. Kadler
Karl E. Kadler University of Manchester
John W. Kappler
John W. Kappler National Jewish Health
David A. Ostrov
David A. Ostrov University of Florida
Michael A. Weiss
Michael A. Weiss Case Western Reserve University
Judith Klumperman
Judith Klumperman Utrecht University
Michael P. Lisanti
Michael P. Lisanti University of Salford
Fuminori Tokunaga
Fuminori Tokunaga Osaka Metropolitan University
Ray Boot-Handford
Ray Boot-Handford University of Manchester
Philippe Froguel
Philippe Froguel Imperial College London

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