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Judith Klumperman

Judith Klumperman

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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
92
Citations
28764
World Ranking
2222
National Ranking
47

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Judith Klumperman is affiliated with Utrecht University in the Netherlands. Their research spans multiple fields within biochemistry, genetics, molecular biology, and medicine, with a particular focus on cell biology and molecular biology. Their work frequently addresses topics such as cellular transport and secretion, calcium signaling and nucleotide metabolism, lysosomal storage disorders, endoplasmic reticulum stress and disease, autophagy, and advanced microscopy techniques.

Recent publications by Judith Klumperman include:

  • Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models, 2022, Nature Aging
  • An Organoid for Woven Bone, 2021, Advanced Functional Materials
  • α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes, 2021, PLoS Biology
  • <scp>SKIP</scp> - <scp>HOPS</scp> recruits <scp>TBC</scp> 1D15 for a Rab7-to-Arl8b identity switch to control late endosome transport, 2020, The EMBO Journal
  • Quantitative correlative microscopy reveals the ultrastructural distribution of endogenous endosomal proteins, 2021, The Journal of Cell Biology

Their frequent co-authors include:

  • Nalan Liv
  • Cecilia de Heus
  • Tineke Veenendaal
  • Ann De Mazière
  • Job Fermie

Judith Klumperman has published extensively in several venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • The Journal of Cell Biology
  • PLoS Biology
  • The EMBO Journal

Their work contributes primarily to the subfields of cell biology, molecular biology, physiology, epidemiology, and immunology. The main topics covered in their research are:

  • Cellular transport and secretion
  • Calcium signaling and nucleotide metabolism
  • Lysosomal Storage Disorders Research
  • Endoplasmic Reticulum Stress and Disease
  • Autophagy in Disease and Therapy
  • Advanced Electron Microscopy Techniques and Applications
  • Advanced Fluorescence Microscopy Techniques

Recognition of their contributions includes being named a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

    Paul Saftig;Judith Klumperman

  • Termination of autophagy and reformation of lysosomes regulated by mTOR

    Li Yu;Christina K. McPhee;Christina K. McPhee;Lixin Zheng;Gonzalo A. Mardones;Gonzalo A. Mardones

  • Trafficking and function of the tetraspanin CD63.

    Maaike S. Pols;Judith Klumperman

  • A glia-derived acetylcholine-binding protein that modulates synaptic transmission

    August B. Smit;Naweed I. Syed;Dick Schaap;Jan van Minnen

  • Endocytosis and Sorting of ErbB2 and the Site of Action of Cancer Therapeutics Trastuzumab and Geldanamycin

    Cary D. Austin;Ann M. De Mazière;Paul I. Pisacane;Suzanne M. van Dijk

  • Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.

    Mario Pende;Sara C. Kozma;Muriel Jaquet;Viola Oorschot

  • Sorting Nexin-1 Mediates Tubular Endosome-to-TGN Transport through Coincidence Sensing of High- Curvature Membranes and 3-Phosphoinositides

    Jez Carlton;Miriam Bujny;Brian J. Peter;Viola M.J. Oorschot

  • Autophagy proteins regulate the secretory component of osteoclastic bone resorption

    Carl J. DeSelm;Brian C. Miller;Wei Zou;Wandy L. Beatty

  • Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

    Michael Degtyarev;Ann De Mazière;Christine Orr;Jie Lin

  • Association of the AP-3 adaptor complex with clathrin

    Esteban C. Dell'Angelica;Judith Klumperman;Judith Klumperman;Willem Stoorvogel;Willem Stoorvogel;Juan S. Bonifacino;Juan S. Bonifacino

  • Bilayered Clathrin Coats on Endosomal Vacuoles Are Involved in Protein Sorting toward Lysosomes

    Martin Sachse;Sylvie Urbé;Viola Oorschot;Ger J. Strous

  • Vesicular Tubular Clusters between the ER and Golgi Mediate Concentration of Soluble Secretory Proteins by Exclusion from COPI-Coated Vesicles

    José A. Martínez-Menárguez;Hans J. Geuze;Jan W. Slot;Judith Klumperman

  • The Complex Ultrastructure of the Endolysosomal System

    Judith Klumperman;Graça Raposo;Graça Raposo

  • Coronavirus M proteins accumulate in the Golgi complex beyond the site of virion budding.

    J Klumperman;J K Locker;A Meijer;M C Horzinek

  • Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins

    Andrew A. Peden;Viola Oorschot;Boris A. Hesser;Cary D. Austin

  • Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

    Borislav Dejanovic;Melanie A. Huntley;Ann De Mazière;William J. Meilandt

  • Sunday Driver links axonal transport to damage signaling

    Valeria Cavalli;Pekka Kujala;Judith Klumperman;Lawrence S.B. Goldstein

  • Syntaxin 6 functions in trans-Golgi network vesicle trafficking.

    J B Bock;J Klumperman;S Davanger;R H Scheller

  • Syntaxin 13 Mediates Cycling of Plasma Membrane Proteins via Tubulovesicular Recycling Endosomes

    Rytis Prekeris;Judith Klumperman;Yu A. Chen;Richard H. Scheller

  • Mannose 6–Phosphate Receptors Are Sorted from Immature Secretory Granules via Adaptor Protein AP-1, Clathrin, and Syntaxin 6–positive Vesicles

    Judith Klumperman;Regina Kuliawat;Janice M. Griffith;Hans J. Geuze

Frequent Co-Authors

Viola Oorschot
Viola Oorschot Utrecht University
Peter van der Sluijs
Peter van der Sluijs Utrecht University
Hans J. Geuze
Hans J. Geuze Utrecht University
Ger J. Strous
Ger J. Strous BIMINI Biotech
Rytis Prekeris
Rytis Prekeris University of Colorado Anschutz Medical Campus
Jan W. Slot
Jan W. Slot Utrecht University
Casper C. Hoogenraad
Casper C. Hoogenraad Utrecht University
David Chitayat
David Chitayat University of Toronto
Edward E. S. Nieuwenhuis
Edward E. S. Nieuwenhuis Utrecht University

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