What is he best known for?
The fields of study he is best known for:
Wim Annaert mainly focuses on Cell biology, Presenilin, Amyloid precursor protein, Amyloid precursor protein secretase and Biochemistry.
His Cell biology research is multidisciplinary, incorporating elements of Cell cycle and Regulated Intramembrane Proteolysis.
Presenilin and Phenotype are frequently intertwined in his study.
His Amyloid precursor protein research incorporates themes from Molecular biology and Binding site.
His Amyloid precursor protein secretase research incorporates elements of Gamma secretase, Protease, Signal transduction and Endosome.
Wim Annaert has researched Biochemistry in several fields, including Nicastrin and Amyloid.
His most cited work include:
- Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein (1594 citations)
- Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling (584 citations)
- The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. (543 citations)
What are the main themes of his work throughout his whole career to date?
Wim Annaert spends much of his time researching Cell biology, Presenilin, Amyloid precursor protein, Biochemistry and Amyloid precursor protein secretase.
Wim Annaert interconnects Endocytosis and Amyloid in the investigation of issues within Cell biology.
Wim Annaert has included themes like Membrane protein, Regulated Intramembrane Proteolysis, Transmembrane protein and Signal transduction in his Presenilin study.
His work carried out in the field of Amyloid precursor protein brings together such families of science as Gamma secretase and Neuroscience.
His research in Golgi apparatus focuses on subjects like Molecular biology, which are connected to Conserved oligomeric Golgi complex and Mutation.
His APH-1 study combines topics from a wide range of disciplines, such as PEN-2, Gamma-secretase complex and Alpha secretase.
He most often published in these fields:
- Cell biology (55.40%)
- Presenilin (39.57%)
- Amyloid precursor protein (35.25%)
What were the highlights of his more recent work (between 2018-2021)?
- Cell biology (55.40%)
- Super-resolution microscopy (3.60%)
- PIKFYVE (2.16%)
In recent papers he was focusing on the following fields of study:
His main research concerns Cell biology, Super-resolution microscopy, PIKFYVE, Amyloid and γ secretase.
The study incorporates disciplines such as Integral membrane protein, Endocytic cycle, Lysosome and Presenilin in addition to Cell biology.
The various areas that he examines in his Presenilin study include Regulated Intramembrane Proteolysis and Transmembrane protein.
His Transmembrane protein study integrates concerns from other disciplines, such as Gamma secretase, Nicastrin and Transmembrane domain.
His Nicastrin study improves the overall literature in Amyloid precursor protein.
While the research belongs to areas of γ secretase, he spends his time largely on the problem of Crystallography, intersecting his research to questions surrounding Cell.
Between 2018 and 2021, his most popular works were:
- Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors. (50 citations)
- ATP13A2 deficiency disrupts lysosomal polyamine export (38 citations)
- Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export (25 citations)
In his most recent research, the most cited papers focused on:
Wim Annaert mainly investigates Cell biology, Amyloid, Integral membrane protein, Autophagy and Receptor.
His Cell biology research is multidisciplinary, relying on both Polyamine transport, Biogenesis and Nicastrin.
Endosome is closely connected to Lysosome in his research, which is encompassed under the umbrella topic of Biogenesis.
His Nicastrin study necessitates a more in-depth grasp of Presenilin.
His research integrates issues of Endocytic cycle, Disease and Ageing in his study of Autophagy.
His biological study spans a wide range of topics, including Lipid droplet, Microscale thermophoresis, Cholesterol and Protein domain.
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