Wim Annaert mainly focuses on Cell biology, Presenilin, Amyloid precursor protein, Amyloid precursor protein secretase and Biochemistry. His Cell biology research is multidisciplinary, incorporating elements of Cell cycle and Regulated Intramembrane Proteolysis. Presenilin and Phenotype are frequently intertwined in his study.
His Amyloid precursor protein research incorporates themes from Molecular biology and Binding site. His Amyloid precursor protein secretase research incorporates elements of Gamma secretase, Protease, Signal transduction and Endosome. Wim Annaert has researched Biochemistry in several fields, including Nicastrin and Amyloid.
Wim Annaert spends much of his time researching Cell biology, Presenilin, Amyloid precursor protein, Biochemistry and Amyloid precursor protein secretase. Wim Annaert interconnects Endocytosis and Amyloid in the investigation of issues within Cell biology. Wim Annaert has included themes like Membrane protein, Regulated Intramembrane Proteolysis, Transmembrane protein and Signal transduction in his Presenilin study.
His work carried out in the field of Amyloid precursor protein brings together such families of science as Gamma secretase and Neuroscience. His research in Golgi apparatus focuses on subjects like Molecular biology, which are connected to Conserved oligomeric Golgi complex and Mutation. His APH-1 study combines topics from a wide range of disciplines, such as PEN-2, Gamma-secretase complex and Alpha secretase.
His main research concerns Cell biology, Super-resolution microscopy, PIKFYVE, Amyloid and γ secretase. The study incorporates disciplines such as Integral membrane protein, Endocytic cycle, Lysosome and Presenilin in addition to Cell biology. The various areas that he examines in his Presenilin study include Regulated Intramembrane Proteolysis and Transmembrane protein.
His Transmembrane protein study integrates concerns from other disciplines, such as Gamma secretase, Nicastrin and Transmembrane domain. His Nicastrin study improves the overall literature in Amyloid precursor protein. While the research belongs to areas of γ secretase, he spends his time largely on the problem of Crystallography, intersecting his research to questions surrounding Cell.
Wim Annaert mainly investigates Cell biology, Amyloid, Integral membrane protein, Autophagy and Receptor. His Cell biology research is multidisciplinary, relying on both Polyamine transport, Biogenesis and Nicastrin. Endosome is closely connected to Lysosome in his research, which is encompassed under the umbrella topic of Biogenesis.
His Nicastrin study necessitates a more in-depth grasp of Presenilin. His research integrates issues of Endocytic cycle, Disease and Ageing in his study of Autophagy. His biological study spans a wide range of topics, including Lipid droplet, Microscale thermophoresis, Cholesterol and Protein domain.
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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
Bart De Strooper;Paul Saftig;Paul Saftig;Katleen Craessaerts;Hugo Vanderstichele.
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Dieter Hartmann;Bart De Strooper;Lutgarde Serneels;Kathleen Craessaerts.
Human Molecular Genetics (2002)
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling
Sara Cipolat;Tomasz Rudka;Dieter Hartmann;Veronica Costa.
Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.
An Herreman;Lutgarde Serneels;Wim Annaert;Desiré Collen.
Nature Cell Biology (2000)
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
An Herreman;Dieter Hartmann;Wim Annaert;Paul Saftig.
Proceedings of the National Academy of Sciences of the United States of America (1999)
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death.
Abhishek D Garg;Dmitri V Krysko;Tom Verfaillie;Agnieszka Kaczmarek.
The EMBO Journal (2012)
Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons.
Wim G. Annaert;Lyne Levesque;Kathleen Craessaerts;Inge Dierinck.
Journal of Cell Biology (1999)
Impaired glycosylation and cutis laxa caused by mutations in the vesicular H+-ATPase subunit ATP6V0A2.
Uwe Kornak;Ellen Reynders;Aikaterini Dimopoulou;Jeroen Van Reeuwijk.
Nature Genetics (2008)
Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease
Bart De Strooper;Wim Annaert.
Annual Review of Cell and Developmental Biology (2010)
Tumor Vessel Normalization by Chloroquine Independent of Autophagy
Hannelore Maes;Anna Kuchnio;Aleksandar Peric;Stijn Moens.
Cancer Cell (2014)
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