Wim Annaert

Overview

Best Publications

• A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

  Bart De Strooper;Wim Annaert;Philippe Cupers;Paul Saftig

  2785
  Citations

• Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

  Bart De Strooper;Paul Saftig;Paul Saftig;Katleen Craessaerts;Hugo Vanderstichele

  2450
  Citations

• The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

  Dieter Hartmann;Bart De Strooper;Lutgarde Serneels;Kathleen Craessaerts

  868
  Citations

• Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling

  Sara Cipolat;Tomasz Rudka;Dieter Hartmann;Veronica Costa

  868
  Citations

• A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death.

  Abhishek D Garg;Dmitri V Krysko;Tom Verfaillie;Agnieszka Kaczmarek

  805
  Citations

• Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

  An Herreman;Dieter Hartmann;Wim Annaert;Paul Saftig

  753
  Citations

• Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

  An Herreman;Lutgarde Serneels;Wim Annaert;Desiré Collen

  725
  Citations

• Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons.

  Wim G. Annaert;Lyne Levesque;Kathleen Craessaerts;Inge Dierinck

  424
  Citations

• Impaired glycosylation and cutis laxa caused by mutations in the vesicular H+-ATPase subunit ATP6V0A2.

  Uwe Kornak;Ellen Reynders;Aikaterini Dimopoulou;Jeroen Van Reeuwijk

  420
  Citations

• Tumor Vessel Normalization by Chloroquine Independent of Autophagy

  Hannelore Maes;Anna Kuchnio;Aleksandar Peric;Stijn Moens

  411
  Citations

• A cell biological perspective on Alzheimer's disease.

  Wim Annaert;Bart De Strooper

  314
  Citations

• The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture.

  Philippe Cupers;Isabelle Orlans;Katleen Craessaerts;Wim Annaert

  303
  Citations

• Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

  Ragna Sannerud;Cary Esselens;Paulina Ejsmont;Rafael Mattera

  289
  Citations

• Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

  Bart De Strooper;Wim Annaert

  286
  Citations

• Pathogenic APP mutations near the γ-secretase cleavage site differentially affect Aβ secretion and APP C-terminal fragment stability

  Chris De Jonghe;Cary Esselens;Samir Kumar-Singh;Katleen Craessaerts

  278
  Citations

• ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1.

  Ragna Sannerud;Ilse Declerck;Aleksandar Peric;Tim Raemaekers

  268
  Citations

• NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization

  Tim Raemaekers;Katharina Ribbeck;Joël Beaudouin;Wim Annaert

  265
  Citations

• Processing of β-Secretase by Furin and Other Members of the Proprotein Convertase Family

  John W.M. Creemers;Diana Ines Dominguez;Evelyn Plets;Lutgarde Serneels

  263
  Citations

• ATP13A2 deficiency disrupts lysosomal polyamine export

  Sarah van Veen;Shaun Martin;Chris Van den Haute;Veronick Benoy

  247
  Citations

• gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation.

  An Herreman;Geert Van Gassen;Mustapha Bentahir;Omar Nyabi

  244
  Citations