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Edward E. S. Nieuwenhuis

Edward E. S. Nieuwenhuis

D-Index & Metrics

Microbiology

D-Index
58
Citations
19801
World Ranking
3360
National Ranking
131

Overview

Edward E. S. Nieuwenhuis is affiliated with Utrecht University in the Netherlands. Their research spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a notable focus on Molecular Biology, Surgery, and Genetics. Additional subfields include Pulmonary and Respiratory Medicine and Immunology.

Nieuwenhuis has contributed extensively to several topics within biomedical research. These topics include:

  • CRISPR and Genetic Engineering
  • RNA modifications and cancer
  • Sepsis Diagnosis and Treatment
  • Virus-based gene therapy research
  • Liver physiology and pathology
  • Organ Transplantation Techniques and Outcomes
  • RNA and protein synthesis mechanisms

Their recent publication record highlights important contributions in these areas. Selected papers include:

  • Prime editing for functional repair in patient-derived disease models, 2020, Nature Communications
  • Treatment of ARS deficiencies with specific amino acids, 2021, Genetics in Medicine
  • Correlates of Fatigability in Patients With Spinal Muscular Atrophy, 2020, Neurology
  • H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts, 2020, Clinical Epigenetics
  • Prime editing for functional repair in patient-derived disease models, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Nieuwenhuis regularly collaborates with a network of frequent co-authors. These include Sabine A. Fuchs, Michal Mokrý, Imre F. Schene, Indi P. Joore, and Ewart Kuijk. Their work is often published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Endoscopy, Nature Communications, Mucosal Immunology, and Pediatric Blood & Cancer.

The scientific output of Nieuwenhuis includes a strong presence in preprint repositories as well as peer-reviewed journals. Their research appears across diverse journals, reflecting a multidisciplinary approach and a focus on translational and clinical aspects of molecular medicine and genetic engineering.

Nieuwenhuis' expertise and publication record demonstrate sustained research activity especially in emerging gene editing techniques like prime editing, as well as in clinical applications relating to genetic disease and organ physiology.

Best Publications

  • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

    Arthur Kaser;Ann-Hwee Lee;Andre Franke;Jonathan N. Glickman

  • Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

    Meritxell Huch;Helmuth Gehart;Ruben van Boxtel;Karien Hamer

  • Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

    Gerald Schwank;Bon Kyoung Koo;Valentina Sasselli;Johanna F. Dekkers

  • Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

    Caroline A. Lindemans;Caroline A. Lindemans;Marco Calafiore;Anna M. Mertelsmann;Margaret H. O'Connor

  • A functional CFTR assay using primary cystic fibrosis intestinal organoids

    Johanna F Dekkers;Caroline L Wiegerinck;Hugo R de Jonge;Inez Bronsveld

  • Tissue-specific mutation accumulation in human adult stem cells during life

    Francis Blokzijl;Joep de Ligt;Myrthe Jager;Valentina Sasselli

  • Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells.

    Frank Heller;Ivan J Fuss;Edward E Nieuwenhuis;Edward E Nieuwenhuis;Richard S Blumberg

  • The Transcription Factor T-bet Regulates Mucosal T Cell Activation in Experimental Colitis and Crohn's Disease

    M.F. Neurath;B. Weigmann;S. Finotto;J. Glickman

  • Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

    Johanna F. Dekkers;Gitte Berkers;Evelien Kruisselbrink;Annelotte Vonk

  • Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis.

    Leonie A Boven;Marjan Van Meurs;Marloes Van Zwam;Annet Wierenga-Wolf

  • CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung

    Edward E.S. Nieuwenhuis;Tetsuya Matsumoto;Mark Exley;Robbert A. Schleipman

  • Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.

    Henner F. Farin;Wouter R. Karthaus;Pekka Kujala;Maryam Rakhshandehroo

  • Adult Stem Cells in the Small Intestine Are Intrinsically Programmed with Their Location-Specific Function

    Sabine Middendorp;Kerstin Schneeberger;Caroline L Wiegerinck;Michal Mokry

  • Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice

    Sahar El Aidy;Peter van Baarlen;Muriel Derrien;Dicky J Lindenbergh-Kortleve

  • Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured “Miniguts”

    Wim de Lau;Pekka Kujala;Kerstin Schneeberger;Sabine Middendorp

  • Canonical Wnt signaling negatively modulates regulatory T cell function

    Jorg van Loosdregt;Veerle Fleskens;Machteld M. Tiemessen;Michal Mokry

  • IPEX as a result of mutations in FOXP3.

    Hans J. J. van der Vliet;Edward E. Nieuwenhuis

  • Natural killer T cells in adipose tissue prevent insulin resistance

    Henk S Schipper;Maryam Rakhshandehroo;Stan F J van de Graaf;Koen Venken

  • Effects of beta-adrenergic blockade on immunologic and cardiovascular changes induced by mental stress.

    R. J. Benschop;E. E. S. Nieuwenhuis;E. A. M. Tromp;G. L. R. Godaert

  • EBV-Induced Gene 3 Transcription Is Induced by TLR Signaling in Primary Dendritic Cells via NF-κB Activation

    Stefan Wirtz;Christoph Becker;Massimo C. Fantini;Edward E. Nieuwenhuis

Frequent Co-Authors

Michal Mokry
Michal Mokry Utrecht University
Richard S. Blumberg
Richard S. Blumberg Brigham and Women's Hospital
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Berent J. Prakken
Berent J. Prakken Utrecht University
Paul J. Coffer
Paul J. Coffer Utrecht University
Markus F. Neurath
Markus F. Neurath University of Erlangen-Nuremberg
Edwin Cuppen
Edwin Cuppen Utrecht University
Alex van Belkum
Alex van Belkum BaseClear B.V.
Hubert P. Endtz
Hubert P. Endtz Erasmus University Rotterdam

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