His primary areas of investigation include Immunology, Stem cell, Organoid, Immune system and Cytokine. The study incorporates disciplines such as Stimulation and Intestinal mucosa in addition to Immunology. His Stimulation research integrates issues from Oxazolone, Pathogenesis, Ulcerative colitis, T-cell receptor and Interleukin 13.
His Intestinal mucosa research is multidisciplinary, incorporating perspectives in Paneth cell and Inflammatory bowel disease. His research integrates issues of LGR5 and Cellular differentiation, Adult stem cell in his study of Stem cell. His Organoid research is multidisciplinary, relying on both Molecular biology, Cystic fibrosis and Intestinal epithelium.
Edward E. S. Nieuwenhuis spends much of his time researching Immunology, Immune system, Cell biology, Internal medicine and Organoid. His biological study spans a wide range of topics, including Intestinal mucosa and Inflammatory bowel disease. As a part of the same scientific study, Edward E. S. Nieuwenhuis usually deals with the Inflammatory bowel disease, concentrating on Ulcerative colitis and frequently concerns with Colitis.
His studies deal with areas such as Cytokine and Microbiology as well as Immune system. His Internal medicine study incorporates themes from Gastroenterology and Endocrinology. His Organoid study which covers Stem cell that intersects with Cellular differentiation.
Edward E. S. Nieuwenhuis mostly deals with Organoid, Computational biology, Gene, Prime and Immune system. Edward E. S. Nieuwenhuis combines subjects such as Less invasive, Clinical trial, MEDLINE, Mutation and Intervention with his study of Organoid. The various areas that Edward E. S. Nieuwenhuis examines in his Immune system study include Psychological intervention, Incidence, Cytokine and Etiology.
Edward E. S. Nieuwenhuis has researched Cytokine in several fields, including T cell migration and T cell chemotaxis. His T cell study contributes to a more complete understanding of Immunology. As part of one scientific family, Edward E. S. Nieuwenhuis deals mainly with the area of Tumor necrosis factor alpha, narrowing it down to issues related to the Stem cell, and often Stimulation, Lipotoxicity and Unfolded protein response.
His scientific interests lie mostly in Computational biology, Gene, Immune system, Pediatrics and Homology directed repair. His Computational biology research is multidisciplinary, incorporating elements of Enhancer, Transcription factor, Epigenetics, Noncoding DNA and Candidate gene. His research in Immune system intersects with topics in Tumor necrosis factor alpha, Incidence, Inflammatory bowel disease and Etiology.
His studies deal with areas such as Very early onset, Young adult and Psychological intervention as well as Pediatrics. His Homology directed repair research spans across into fields like Genome editing, HEK 293 cells, Organoid, Mutation and Adult stem cell. Edward E. S. Nieuwenhuis integrates Genome editing and Prime in his research.
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XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
Arthur Kaser;Ann-Hwee Lee;Andre Franke;Jonathan N. Glickman.
Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
Gerald Schwank;Bon Kyoung Koo;Valentina Sasselli;Johanna F. Dekkers.
Cell Stem Cell (2013)
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
Meritxell Huch;Helmuth Gehart;Ruben van Boxtel;Karien Hamer.
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells.
Frank Heller;Ivan J Fuss;Edward E Nieuwenhuis;Edward E Nieuwenhuis;Richard S Blumberg.
A functional CFTR assay using primary cystic fibrosis intestinal organoids
Johanna F Dekkers;Caroline L Wiegerinck;Hugo R de Jonge;Inez Bronsveld.
Nature Medicine (2013)
The Transcription Factor T-bet Regulates Mucosal T Cell Activation in Experimental Colitis and Crohn's Disease
M.F. Neurath;B. Weigmann;S. Finotto;J. Glickman.
Journal of Experimental Medicine (2002)
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration
Caroline A. Lindemans;Caroline A. Lindemans;Marco Calafiore;Anna M. Mertelsmann;Margaret H. O'Connor.
Tissue-specific mutation accumulation in human adult stem cells during life
Francis Blokzijl;Joep de Ligt;Myrthe Jager;Valentina Sasselli.
CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung
Edward E.S. Nieuwenhuis;Tetsuya Matsumoto;Mark Exley;Robbert A. Schleipman.
Nature Medicine (2002)
Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis.
Leonie A Boven;Marjan Van Meurs;Marloes Van Zwam;Annet Wierenga-Wolf.
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