World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
10879
World Ranking
11555
National Ranking
4981

Overview

Y. Peng Loh is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broader fields, their work touches on subfields such as Molecular Biology, Immunology, Endocrinology, Diabetes and Metabolism, Genetics, and Surgery.

The main topics of Y. Peng Loh's research include:

  • Fibroblast Growth Factor Research
  • Immune cells in cancer
  • Phagocytosis and Immune Regulation
  • Retinoids in leukemia and cellular processes
  • Growth Hormone and Insulin-like Growth Factors
  • Estrogen and related hormone effects
  • Adrenal and Paraganglionic Tumors

The scientist has published several papers, with some recent examples being:

  • "Low and High Molecular Weight FGF-2 Have Differential Effects on Astrocyte Proliferation, but Are Both Protective Against Aβ-Induced Cytotoxicity," 2020, Frontiers in Molecular Neuroscience
  • "Nonenzymatic and Trophic Activities of Carboxypeptidase E Regulate Bone Mass and Bioenergetics of Skeletal Stem Cells in Mice," 2020, JBMR Plus
  • "Neurotrophic factor-α1/carboxypeptidase E controls progression and reversal of Alzheimer's disease pathogenesis in mice," 2025, Theranostics
  • "Retraction Note to: Carboxypeptidase E: Elevated Expression Correlated with Tumor Growth and Metastasis in Pheochromocytomas and Other Cancers," 2020, Cellular and Molecular Neurobiology
  • "Advances in EV isolation technology and function," 2021, Extracellular Vesicles and Circulating Nucleic Acids

Y. Peng Loh has collaborated frequently with researchers such as Yong Cheng, Xi Chen, Zhaojin Li, Elissavet Kardami, and Fang-Cheng Fan.

Their work appears in a range of scientific journals, including:

  • Frontiers in Molecular Neuroscience
  • Theranostics
  • JBMR Plus
  • Cellular and Molecular Neurobiology
  • Extracellular Vesicles and Circulating Nucleic Acids

Best Publications

  • Carboxypeptidase E Is a Regulated Secretory Pathway Sorting Receptor: Genetic Obliteration Leads to Endocrine Disorders in Cpefat Mice

    David R Cool;Emmanuel Normant;Fu-sheng Shen;Hao-Chia Chen

  • Chromogranin A, an “On/Off” Switch Controlling Dense-Core Secretory Granule Biogenesis

    Taeyoon Kim;Jung-Hwa Tao-Cheng;Lee E. Eiden;Y.Peng Loh

  • Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease: A Systematic Review and Meta-analysis.

    Xiao-Yan Qin;Shu-Ping Zhang;Chang Cao;Y. Peng Loh

  • Sorting and Activity-Dependent Secretion of BDNF Require Interaction of a Specific Motif with the Sorting Receptor Carboxypeptidase E

    Hong Lou;Soo-Kyung Kim;Eugene Zaitsev;Chris R. Snell

  • Identification of the Sorting Signal Motif within Pro-opiomelanocortin for the Regulated Secretory Pathway

    David R. Cool;Mogens Fenger;Christopher R. Snell;Y. Peng Loh

  • The enzymology and intracellular organization of peptide precursor processing: the secretory vesicle hypothesis

    H Gainer;J T Russell;Y P Loh

  • Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary

    V Y Hook;Y P Loh

  • Dense-core secretory granule biogenesis.

    Taeyoon Kim;Marjorie C. Gondré-Lewis;Irina Arnaoutova;Y. Peng Loh

  • The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

    Leona Plum;Hua V. Lin;Roxanne Dutia;Jun Tanaka

  • 60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides

    Niamh X Cawley;Zhaojin Li;Y Peng Loh

  • Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor.

    Savita Dhanvantari;Y. Peng Loh

  • The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits.

    Niamh X. Cawley;Jiechun Zhou;Joanna M. Hill;Daniel Abebe

  • New Roles of Carboxypeptidase E in Endocrine and Neural Function and Cancer

    Niamh X. Cawley;William C. Wetsel;Saravana R. K. Murthy;Joshua J. Park

  • Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics

    Antonis Voutetakis;Marc R. Kok;Changyu Zheng;Ioannis Bossis

  • Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A.

    Emmanuel Normant;Y. Peng Loh

  • An aminopeptidase activity in bovine pituitary secretory vesicles that cleaves the N-terminal arginine from β-lipotropin60–65

    Harold Gainer;James T. Russell;Y.Peng Loh

  • Chromogranin A and Derived Peptides in Health and Disease

    Y. Peng Loh;Yong Cheng;Sushil K. Mahata;Sushil K. Mahata;Angelo Corti

  • How Peptide Hormone Vesicles Are Transported to the Secretion Site for Exocytosis

    Joshua J. Park;Y. Peng Loh

  • Abnormal sterols in cholesterol-deficiency diseases cause secretory granule malformation and decreased membrane curvature

    Marjorie C. Gondré-Lewis;Horia I. Petrache;Christopher A. Wassif;Daniel Harries

  • Carboxypeptidase E is a sorting receptor for prohormones: binding and kinetic studies.

    David R Cool;Y.Peng Loh

Frequent Co-Authors

Bruce J. Baum
Bruce J. Baum National Institutes of Health
Karel Pacak
Karel Pacak National Institutes of Health
James T. Russell
James T. Russell National Institutes of Health
Maria G. Castro
Maria G. Castro University of Michigan–Ann Arbor
Lee E. Eiden
Lee E. Eiden National Institutes of Health
Angelo Corti
Angelo Corti Vita-Salute San Raffaele University
William C. Wetsel
William C. Wetsel Duke University
Zhuan Zhou
Zhuan Zhou Peking University
Ramona M. Rodriguiz
Ramona M. Rodriguiz Duke University
Elissavet Kardami
Elissavet Kardami University of Manitoba

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