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William C. Wetsel

William C. Wetsel

D-Index & Metrics

Neuroscience

D-Index
83
Citations
22923
World Ranking
1463
National Ranking
731

Overview

William C. Wetsel is affiliated with Duke University in the United States and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, as well as Neuroscience. Their research spans several subfields including Molecular Biology, Cellular and Molecular Neuroscience, Clinical Psychology, Cell Biology, and Materials Chemistry.

Their main research topics cover Receptor Mechanisms and Signaling, Neurotransmitter Receptor Influence on Behavior, Neuroscience and Neuropharmacology Research, Neuropeptides and Animal Physiology, Psychedelics and Drug Studies, Intensive Care Unit Cognitive Disorders, and Anesthesia and Neurotoxicity Research.

Among recent published papers are:

  • Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity, 2022, Nature
  • Psychedelic-inspired drug discovery using an engineered biosensor, 2021, Cell
  • β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors, 2020, Cell
  • Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia, 2020, Alzheimer's & Dementia
  • LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1, 2021, Scientific Reports

Frequent co-authors in their work include:

  • Ramona M. Rodriguiz
  • Bryan L. Roth
  • Vladimir M. Pogorelov
  • Xi-Ping Huang
  • Brian K. Shoichet

William C. Wetsel has published multiple articles in prominent venues such as:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell
  • The FASEB Journal
  • The Cambridge Structural Database

Best Publications

  • Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.

    Raul R. Gainetdinov;William C. Wetsel;Sara R. Jones;Edward D. Levin

  • Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3 -mutant mice

    Jeffrey M. Welch;Jing Lu;Ramona M. Rodriguiz;Nicholas C. Trotta

  • Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

    Xiaoming Wang;Portia A. McCoy;Ramona M. Rodriguiz;Yanzhen Pan

  • Tissue and cellular distribution of the extended family of protein kinase C isoenzymes

    WC Wetsel;WA Khan;I Merchenthaler;H Rivera

  • Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia

    Kathleen M. Caron;Shiu Ching Soo;William C. Wetsel;Douglas M. Stocco

  • Mice lacking the norepinephrine transporter are supersensitive to psychostimulants

    Fei Xu;Raul R. Gainetdinov;William C. Wetsel;Sara R. Jones

  • Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta.

    Barbara J. Davis;David E. Lennard;Christopher A. Lee;Howard F. Tiano

  • Role of GSK3β in behavioral abnormalities induced by serotonin deficiency

    Jean-Martin Beaulieu;Xiaodong Zhang;Ramona M. Rodriguiz;Tatyana D. Sotnikova

  • A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

    Jean-Martin Beaulieu;Sébastien Marion;Ramona M. Rodriguiz;Ivan O. Medvedev

  • Different presynaptic roles of synapsins at excitatory and inhibitory synapses.

    Daniel Gitler;Yoshiko Takagishi;Jian Feng;Yong Ren

  • Discovery of β-Arrestin–Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

    John A. Allen;Julianne M. Yost;Vincent Setola;Xin Chen

  • N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity.

    Niels H Jensen;Ramona M Rodriguiz;Marc G Caron;William C Wetsel

  • Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons.

    William C. Wetsel;Marcelo M. Valenca;Istvan Merchenthaler;Zsolt Liposits

  • Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

    Xiaoming Wang;Alexandra L. Bey;Brittany M. Katz;Alexandra Badea

  • Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function

    Sonia Cohen;Harrison W. Gabel;Martin Hemberg;Ashley N. Hutchinson

  • Mice Deficient for the Vesicular Acetylcholine Transporter Are Myasthenic and Have Deficits in Object and Social Recognition

    Vania F. Prado;Cristina Martins-Silva;Braulio M. de Castro;Ricardo F. Lima

  • Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool.

    B Jill Venton;Andrew T Seipel;Paul E M Phillips;William C Wetsel

  • Aberrant responses in social interaction of dopamine transporter knockout mice

    Ramona M. Rodriguiz;Richard Chu;Marc G. Caron;William C. Wetsel

  • Effects of Castration and Chronic Steroid Treatments on Hypothalamic Gonadotropin-Releasing Hormone Content and Pituitary Gonadotropins in Male Wild-Type and Estrogen Receptor-α Knockout Mice

    Jonathan Lindzey;William C. Wetsel;William C. Wetsel;John F. Couse;Tammy Stoker

  • Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice

    Timothy M Griffin;Timothy M Griffin;Beverley Fermor;Janet L Huebner;Virginia B. Kraus

Frequent Co-Authors

Ramona M. Rodriguiz
Ramona M. Rodriguiz Duke University
Stefano Govoni
Stefano Govoni University of Pavia
Yong-hui Jiang
Yong-hui Jiang Yale School of Medicine
Zsolt Liposits
Zsolt Liposits Institute of Experimental Medicine
Richard J. Weinberg
Richard J. Weinberg University of North Carolina at Chapel Hill
Istvan Merchenthaler
Istvan Merchenthaler University of Maryland, Baltimore
Angel V. Peterchev
Angel V. Peterchev Duke University
Tatyana D. Sotnikova
Tatyana D. Sotnikova Italian Institute of Technology
Henry H. Yin
Henry H. Yin Duke University
George J Augustine
George J Augustine Nanyang Technological University

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