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Biology and Biochemistry

D-Index
83
Citations
20378
World Ranking
3579
National Ranking
1790

Overview

Paul F. Pilch is a researcher affiliated with Boston University in the United States. Their work primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with focused subfields including Molecular Biology, Physiology, and Epidemiology.

The scientist's research topics center on metabolism, diabetes, and cancer, as well as adipose tissue and metabolic regulation. Their studies also address adipokines, inflammation, and metabolic diseases, reflecting a multidisciplinary approach to understanding complex biological processes.

Paul F. Pilch has contributed to the academic literature with papers published in peer-reviewed journals. A recent publication from 2020 is titled An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming, which appeared in eLife. This work investigates molecular pathways involved in adipocyte metabolism.

Frequent collaborators in Pilch's research include:

  • Hong Wang
  • Xueping Wan
  • Leif W. Ellisen
  • Susan K. Fried
  • Libin Liu

The main venues for Pilch's publications reflect a focus on high-impact journals, with eLife noted as a frequent publication venue.

The research contributions of Paul F. Pilch align with investigations into the biological mechanisms underpinning metabolic diseases and their cellular regulation. Their interdisciplinary work bridges clinical and molecular perspectives within their fields of study.

Best Publications

  • Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein.

    David E. James;Robert Brown;Javier Navarro;Paul F. Pilch

  • Tumor Necrosis Factor-α-induced Insulin Resistance in 3T3-L1 Adipocytes Is Accompanied by a Loss of Insulin Receptor Substrate-1 and GLUT4 Expression without a Loss of Insulin Receptor-mediated Signal Transduction

    Jacqueline M. Stephens;Jongsoon Lee;Paul F. Pilch

  • Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues

    H Fukumoto;T Kayano;J B Buse;Y Edwards

  • Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

    P F Pilch;M P Czech

  • The insulin receptor: structure, function, and signaling

    J. Lee;P. F. Pilch

  • The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes.

    P F Pilch;M P Czech

  • Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

    M Yaar;S Zhai;P F Pilch;S M Doyle

  • Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance.

    Libin Liu;Dennis Brown;Mary McKee;Nathan K. LeBrasseur

  • Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations.

    A Zorzano;W Wilkinson;N Kotliar;G Thoidis

  • Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting.

    J Berger;C Biswas;P P Vicario;H V Strout

  • Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries.

    Joan Massague;Paul F. Pilch;Michael P. Czech

  • Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

    Erica L. Scheller;Casey R. Doucette;Brian S. Learman;William P. Cawthorn

  • Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

    Mark T. Howes;Matthew Kirkham;James D Riches;Katia Cortese

  • Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles

    Mónica R. Calera;Carmen Martinez;Hongzhi Liu;Amr K. El Jack

  • Stimulation of tyrosine-specific phosphorylation in vitro by insulin-like growth factor I

    Joshua B. Rubin;Michael A. Shia;Paul F. Pilch

  • MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes

    Michele Bastiani;Libin Liu;Michelle M. Hill;Mark P. Jedrychowski

  • Stimulation of collagen formation by insulin and insulin-like growth factor I in cultures of human lung fibroblasts.

    Ronald H. Goldstein;Christine F. Poliks;Paul F. Pilch;Barbara D. Smith

  • A Critical Role of Cavin (Polymerase I and Transcript Release Factor) in Caveolae Formation and Organization

    Libin Liu;Paul F. Pilch

  • Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha.

    Amr K. El-Jack;Jonathan K. Hamm;Paul F. Pilch;Stephen R. Farmer

  • The beta subunit of the insulin receptor is an insulin-activated protein kinase.

    Michael A. Shia;Paul F. Pilch

Frequent Co-Authors

Michael P. Czech
Michael P. Czech University of Massachusetts Chan Medical School
Mark P. Jedrychowski
Mark P. Jedrychowski Harvard University
Stephen R. Farmer
Stephen R. Farmer Boston University
Robert G. Parton
Robert G. Parton University of Queensland
Antonio Zorzano
Antonio Zorzano University of Barcelona
David E. James
David E. James University of Sydney
Steven P. Gygi
Steven P. Gygi Harvard University
John F. Hancock
John F. Hancock The University of Texas Health Science Center at Houston
Steven E. Shoelson
Steven E. Shoelson Harvard University
Barbara E. Corkey
Barbara E. Corkey Boston University

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