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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
15518
World Ranking
13003
National Ranking
926

Overview

Hubert Schorle is affiliated with the University Hospital Bonn in Germany. Their research spans primarily the fields of biochemistry, genetics, molecular biology, and medicine, with notable contributions across 71 publications in Biochemistry, Genetics and Molecular Biology and 64 in Medicine.

The main subfields of study include molecular biology, reproductive medicine, surgery, public health, environmental and occupational health, and pulmonary and respiratory medicine. These areas reflect the scientist's multidisciplinary approach, often bridging molecular insights with clinical applications.

Key topics in Schorle's work cover a range of biomedical concerns, notably sperm and testicular function, reproductive biology and fertility, renal and related cancers, epigenetics and DNA methylation, testicular diseases and treatments, pluripotent stem cell research, and cancer genomics and diagnostics.

Among recent publications by Schorle are:

  • "Cultivation of Clear Cell Renal Cell Carcinoma Patient-Derived Organoids in an Air-Liquid Interface System as a Tool for Studying Individualized Therapy" (2020, Frontiers in Oncology)
  • "Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice" (2022, Development)
  • "Protamine-2 Deficiency Initiates a Reactive Oxygen Species (ROS)-Mediated Destruction Cascade during Epididymal Sperm Maturation in Mice" (2020, Cells)
  • "Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice" (2022, PLoS Genetics)
  • "The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas" (2021, Molecular Oncology)

Schorle has frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Cell and Developmental Biology, Development, Cells, and the European Journal of Cancer, indicating a strong presence in both preprint and peer-reviewed journals relevant to cell biology and oncology.

Collaborations are notable with co-authors including Lena Arévalo, Simon Schneider, Gina Esther Merges, Daniel Nettersheim, and Klaus Steger. This network reflects interdisciplinary and collaborative research efforts, frequently involving reproductive biology, molecular genetics, and oncology.

Best Publications

  • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene.

    Benjamin Sadlack;Hartmut Merz;Hubert Schorle;Anneliese Schimpl

  • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting.

    Hubert Schorle;Thomas Holtschke;Thomas Hünig;Anneliese Schimpl

  • TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome

    Sandra Merscher;Birgit Funke;Jonathan A. Epstein;Joerg Heyer

  • Transcription factor AP-2 essential for cranial closure and craniofacial development

    Hubert Schorle;Pascal Meier;Michael Buchert;Rudolf Jaenisch

  • Immune responses in interleukin-2-deficient mice

    Thomas M. Kündig;Hubert Schorle;Martin F. Bachmann;Hans Hengartner

  • Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

    Benjamin Sadlack;Jürgen Löhler;Hubert Schorle;Gabriele Klebb

  • The AP-2 family of transcription factors.

    Dawid Eckert;Sandra Buhl;Susanne Weber;Richard Jäger

  • Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control

    Kristina Hilger-Eversheim;Markus Moser;Hubert Schorle;Reinhard Buettner

  • PDGF signalling controls age-dependent proliferation in pancreatic β-cells

    Hainan Chen;Xueying Gu;Yinghua Liu;Jing Wang

  • Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot–Marie–Tooth neuropathy type 4B2/11p15

    Jan Senderek;Carsten Bergmann;Susanne Weber;Uwe-Peter Ketelsen

  • Reference Gene Validation for RT-qPCR, a Note on Different Available Software Packages

    Ward De Spiegelaere;Jutta Dern-Wieloch;Roswitha Weigel;Valérie Schumacher

  • Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics.

    Stephane Belin;Homaira Nawabi;Chen Wang;Shaojun Tang

  • Transcription factor gene AP-2γ essential for early murine development

    Uwe Werling;Hubert Schorle

  • Essential Role of Ubiquitin-Specific Protease 8 for Receptor Tyrosine Kinase Stability and Endocytic Trafficking In Vivo

    Sandra Niendorf;Alexander Oksche;Agnes Kisser;Jürgen Löhler

  • Critical Function of AP-2gamma/TCFAP2C in Mouse Embryonic Germ Cell Maintenance

    Susanne Weber;Dawid Eckert;Daniel Nettersheim;Ad J.M. Gillis

  • Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth

    Richard Jennemann;Roger Sandhoff;Shijun Wang;Eva Kiss

  • Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5.

    Jeanne-Françoise Roth;Noriko Shikama;Clea Henzen;Isabelle Desbaillets

  • Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

    Benjamin Sadlack;Ralf Kühn;Hubert Schorle;Klaus Rajewsky

  • Valproic Acid Confers Functional Pluripotency to Human Amniotic Fluid Stem Cells in a Transgene-free Approach

    Dafni Moschidou;Sayandip Mukherjee;Michael P Blundell;Katharina Drews

  • Reference Gene Validation for RT-qPCR, a Note on Different Available Software

    Ward De Spiegelaere;Jutta Dern-Wieloch;Roswitha Weigel;Valérie Schumacher

Frequent Co-Authors

Ivan D. Horak
Ivan D. Horak Freie Universität Berlin
Reinhard Büttner
Reinhard Büttner University Hospital Cologne
Leendert H. J. Looijenga
Leendert H. J. Looijenga Princess Máxima Center
Markus Moser
Markus Moser Technical University of Munich
Johannes H. Schulte
Johannes H. Schulte Charité - University Medicine Berlin
Oliver Brüstle
Oliver Brüstle University Hospital Bonn
Myriam Hemberger
Myriam Hemberger University of Calgary
Magdalena Götz
Magdalena Götz Ludwig-Maximilians-Universität München

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