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Immunology

D-Index
69
Citations
18901
World Ranking
2498
National Ranking
1198

Overview

Thomas R. Malek is affiliated with the University of Miami in the United States. Their research primarily focuses on immunology and microbiology, with significant contributions to the fields of medicine, oncology, genetics, radiology, nuclear medicine, imaging, and surgery.

Their work spans multiple subfields, including:

  • Immunology
  • Oncology
  • Genetics
  • Radiology, Nuclear Medicine and Imaging
  • Surgery

Thomas R. Malek has explored various main topics of study in their research, which include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • Atherosclerosis and Cardiovascular Diseases
  • CAR-T cell therapy research
  • Diabetes and associated disorders

Their recent publications illustrate a focus on immune signaling and immunotherapy, with notable works such as:

  • Engineering IL-2 for immunotherapy of autoimmunity and cancer (2022) in Nature Reviews. Immunology
  • Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer (2024) in Immunity
  • Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms (2020) in Diabetes
  • High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4+ and CD8+ neoantigen-specific T cells to promote antitumor immunity (2021) in Journal for ImmunoTherapy of Cancer
  • Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumor-specific CD8+ T cells (2023) in Journal for ImmunoTherapy of Cancer

They have frequently published in venues such as:

  • The Journal of Immunology
  • Diabetes
  • Journal for ImmunoTherapy of Cancer
  • American Journal Of Pathology
  • Transplantation and Cellular Therapy

Thomas R. Malek's collaborative work involves multiple frequent co-authors, including:

  • Rosmely Hernandez
  • Aixin Yu
  • Kathryn M LaPorte
  • Alejandro Moro
  • Sabrina Copsel

Best Publications

  • The Biology of Interleukin-2

    Thomas R. Malek

  • CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice: Implications for the Nonredundant Function of IL-2

    Thomas R Malek;Aixin Yu;Vladimir Vincek;Paul Scibelli

  • Tolerance, not immunity, crucially depends on IL-2.

    Thomas R. Malek;Allison L. Bayer

  • Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

    Thomas R. Malek;Iris Castro

  • Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family.

    T J Fleming;M L Fleming;T R Malek

  • The main function of IL-2 is to promote the development of T regulatory cells.

    Thomas R. Malek

  • Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex

    Thomas R. Malek;Richard J. Robb;Ethan M. Shevach

  • T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4.

    Kurt C. Gunter;Thomas R. Malek;Ethan M. Shevach

  • IL-15 and IL-2: a matter of life and death for T cells in vivo.

    Xian Chang Li;Gulcin Demirci;Sylvie Ferrari-Lacraz;Chris Groves

  • A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.

    Aixin Yu;Linjian Zhu;Norman H. Altman;Thomas R. Malek

  • Distinct Activation Signals Determine whether IL-21 Induces B Cell Costimulation, Growth Arrest, or Bim-Dependent Apoptosis

    Haoli Jin;Roberto Carrio;Aixin Yu;Thomas R. Malek

  • T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells.

    Guoyan Cheng;Aixin Yu;Thomas R. Malek

  • Engineering IL-2 for immunotherapy of autoimmunity and cancer

    Unknown

  • Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

    Michelle Rosenzwajg;Guillaume Churlaud;Roberto Mallone;Adrien Six

  • Regulatory T cells in the treatment of disease

    Amir Sharabi;Maria G. Tsokos;Ying Ding;Thomas R. Malek

  • Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period.

    Allison L Bayer;Aixin Yu;Dennis O. Adeegbe;Thomas R Malek

  • Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.

    You Wen He;Thomas R. Malek

  • The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells.

    G Ortega;R J Robb;E M Shevach;T R Malek

  • Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes.

    Aixin Yu;Isaac Snowhite;Francesco Vendrame;Michelle Rosenzwajg;Michelle Rosenzwajg

  • Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies.

    Thomas R. Malek;Gustavo Ortega;Gustavo Ortega;Christina Chan;Richard A. Kroczek;Richard A. Kroczek

  • Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production.

    Dapeng Gong;Thomas R. Malek

Frequent Co-Authors

Ethan M. Shevach
Ethan M. Shevach National Institute of Allergy and Infectious Diseases
You-Wen He
You-Wen He Duke University
Alberto Pugliese
Alberto Pugliese University of Miami
Eckhard R. Podack
Eckhard R. Podack University of Miami
David Klatzmann
David Klatzmann Sorbonne University
Eli Gilboa
Eli Gilboa University of Miami
Xian Chang Li
Xian Chang Li Cornell University
Michelle Rosenzwajg
Michelle Rosenzwajg Sorbonne University
Jonathan D. Ashwell
Jonathan D. Ashwell National Institutes of Health
Xin Xiao Zheng
Xin Xiao Zheng University of Pittsburgh

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Related Online Degrees & Career Pathways

For those interested in immunology, exploring related online degrees can open doors to diverse career opportunities in healthcare and research. Nursing professionals, for example, often pursue advanced education to enhance their expertise. Understanding the doctorate in nursing salary can help prospective students gauge the financial benefits of obtaining a Doctor of Nursing Practice (DNP) degree, which is especially relevant for those aiming to work in clinical or research settings involving immunological health.

Nurses looking to specialize further might consider bridge programs like the fnp to acute care np bridge program. This pathway allows Family Nurse Practitioners (FNPs) to transition into acute care roles, where advanced knowledge of immunological responses can be crucial in treating complex patients.

For individuals new to nursing or seeking accelerated timelines, options such as accelerated nurse practitioner programs offer a fast track to becoming nurse practitioners. These programs are ideal for motivated students eager to enter the field and contribute to immunology-related healthcare quickly.

Additionally, non-nurses can enter the nursing profession through online ADN programs for non nurses. These accessible online degrees support career changers with foundational nursing skills, enabling them to build a future that can intersect with immunology research or clinical practice.

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