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W. Douglas Fairlie

W. Douglas Fairlie

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
14512
World Ranking
15964
National Ranking
445

Overview

W. Douglas Fairlie is a researcher affiliated with La Trobe University in Australia, specializing in biochemistry, genetics, and molecular biology, with a significant focus also in medicine. Their work spans multiple subfields including molecular biology, epidemiology, pathology and forensic medicine, cell biology, and oncology.

The primary topics addressed in Fairlie's research involve autophagy in disease and therapy, cell death mechanisms and regulation, RNA interference and gene delivery, endoplasmic reticulum stress and disease, as well as cancer mechanisms and therapy. Other focal topics include ubiquitin and proteasome pathways and biomedical research and pathophysiology.

Fairlie has contributed to numerous publications across well-known scientific venues. Frequent publication platforms for their work include:

  • Cell Death Discovery
  • Biochemical Society Transactions
  • Cell Death and Disease
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Communications Biology

Recent papers authored or co-authored by Fairlie highlight research on cell death pathways and cancer biology. Key publications include:

  • Crosstalk between apoptosis and autophagy signaling pathways, 2020, International Review of Cell and Molecular Biology
  • Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer, 2021, International Journal of Molecular Sciences

Other notable recent papers, where Fairlie contributed as co-author or related author, are:

  • BECLIN1: Protein Structure, Function and Regulation, 2021, Cells
  • A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma, 2021, Cell Death Discovery
  • The role of BCL-2 family proteins and therapeutic potential of BH3-mimetics in malignant pleural mesothelioma, 2020, Expert Review of Anticancer Therapy

W. Douglas Fairlie has collaborated frequently with several scientists, establishing ongoing research partnerships with:

  • Erinna F. Lee
  • Sharon Tran
  • John M. Mariadason
  • Laura J. Jenkins
  • Tiffany J. Harris

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

    Simon N. Willis;Jamie I. Fletcher;Thomas Kaufmann;Mark F. van Delft;Mark F. van Delft

  • MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily

    Michelle R. Bootcov;Asne R. Bauskin;Stella M. Valenzuela;Anthony G. Moore

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

    Heiko Johnen;Shu Lin;Tamara Kuffner;David A. Brown

  • Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.

    Peter E. Czabotar;Peter E. Czabotar;Dana Westphal;Dana Westphal;Grant Dewson;Grant Dewson;Stephen Ma;Stephen Ma

  • Structural insights into the degradation of Mcl-1 induced by BH3 domains.

    Peter E. Czabotar;Erinna F. Lee;Mark F. van Delft;Catherine L. Day

  • Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

    Lorraine A. O Reilly;Lin Tai;Lily Lee;Elizabeth A. Kruse;Elizabeth A. Kruse

  • Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

    Stefan P. Glaser;Erinna F. Lee;Evelyn Trounson;Philippe Bouillet

  • Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study

    David A Brown;Samuel N Breit;Julie Buring;W Douglas Fairlie

  • Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

    E F Lee;E F Lee;P E Czabotar;B J Smith;K Deshayes

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands.

    M Kvansakul;H Yang;W D Fairlie;P E Czabotar

  • The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition.

    Dene R. Littler;Stephen J. Harrop;W. Douglas Fairlie;Louise J. Brown

  • Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1

    Catherine L. Day;Callum Smits;F. Cindy Fan;Erinna F. Lee

  • The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins

    Delphine Mérino;Maybelline Giam;Maybelline Giam;Peter D. Hughes;Owen M. Siggs

  • Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

    Jamie I. Fletcher;Sarina Meusburger;Christine J. Hawkins;David T. Riglar

  • Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.

    Delphine Mérino;Delphine Mérino;Seong L. Khaw;Stephan P. Glaser;Stephan P. Glaser;Daniel J. Anderson

  • (alpha/beta+alpha)-Peptide antagonists of BH3 Domain/Bcl-x(L) recognition: Toward general strategies for foldamer-based inhibition of protein-protein interactions

    Jack D. Sadowsky;W. Douglas Fairlie;Erik B. Hadley;Hee Seung Lee

Frequent Co-Authors

Erinna F. Lee
Erinna F. Lee La Trobe University
Peter M. Colman
Peter M. Colman Walter and Eliza Hall Institute of Medical Research
Brian J. Smith
Brian J. Smith QIMR Berghofer Medical Research Institute
David C. S. Huang
David C. S. Huang Walter and Eliza Hall Institute of Medical Research
Peter E. Czabotar
Peter E. Czabotar Walter and Eliza Hall Institute of Medical Research
Guillaume Lessene
Guillaume Lessene Walter and Eliza Hall Institute of Medical Research
Grant Dewson
Grant Dewson Walter and Eliza Hall Institute of Medical Research
Marco J. Herold
Marco J. Herold Walter and Eliza Hall Institute of Medical Research
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research
Philippe Bouillet
Philippe Bouillet Walter and Eliza Hall Institute of Medical Research

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