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D-Index & Metrics

Biology and Biochemistry

D-Index
41
Citations
8509
World Ranking
19545
National Ranking
585

Overview

Erinna F. Lee is affiliated with La Trobe University in Australia and focuses research efforts primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans multiple subfields including Molecular Biology, Epidemiology, Pathology and Forensic Medicine, Cell Biology, and Oncology.

The research topics addressed by Erinna F. Lee encompass a range of areas related to cellular processes and disease mechanisms. Key topics include:

  • Autophagy in Disease and Therapy
  • Cell death mechanisms and regulation
  • RNA Interference and Gene Delivery
  • Endoplasmic Reticulum Stress and Disease
  • Cancer Mechanisms and Therapy
  • Ubiquitin and proteasome pathways
  • Biomedical Research and Pathophysiology

Lee's recent publications reflect a focus on cellular regulation, apoptosis, and cancer biology. Selected papers include:

  • BECLIN1: Protein Structure, Function and Regulation, 2021, Cells
  • Crosstalk between apoptosis and autophagy signaling pathways, 2020, International Review of Cell and Molecular Biology
  • Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer, 2021, International Journal of Molecular Sciences
  • A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma, 2021, Cell Death Discovery
  • The role of BCL-2 family proteins and therapeutic potential of BH3-mimetics in malignant pleural mesothelioma, 2020, Expert Review of Anticancer Therapy

The scientist has collaborated frequently with several co-authors including W. Douglas Fairlie, Sharon Tran, John M. Mariadason, Laura J. Jenkins, and Tiffany J. Harris. These collaborations have contributed to multiple publications across various biology and medical science journals.

Among the frequently chosen venues for publication are:

  • Cell Death Discovery
  • Biochemical Society Transactions
  • Cell Death and Disease
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Communications Biology

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

    Simon N. Willis;Jamie I. Fletcher;Thomas Kaufmann;Mark F. van Delft;Mark F. van Delft

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.

    Peter E. Czabotar;Peter E. Czabotar;Dana Westphal;Dana Westphal;Grant Dewson;Grant Dewson;Stephen Ma;Stephen Ma

  • Structural insights into the degradation of Mcl-1 induced by BH3 domains.

    Peter E. Czabotar;Erinna F. Lee;Mark F. van Delft;Catherine L. Day

  • Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

    Stefan P. Glaser;Erinna F. Lee;Evelyn Trounson;Philippe Bouillet

  • Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

    E F Lee;E F Lee;P E Czabotar;B J Smith;K Deshayes

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

    James E. Vince;Delara Pantaki;Rebecca Feltham;Peter D. Mace

  • Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1

    Catherine L. Day;Callum Smits;F. Cindy Fan;Erinna F. Lee

  • The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins

    Delphine Mérino;Maybelline Giam;Maybelline Giam;Peter D. Hughes;Owen M. Siggs

  • Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

    Jamie I. Fletcher;Sarina Meusburger;Christine J. Hawkins;David T. Riglar

  • Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.

    Delphine Mérino;Delphine Mérino;Seong L. Khaw;Stephan P. Glaser;Stephan P. Glaser;Daniel J. Anderson

  • A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

    Erinna F. Lee;Peter E. Czabotar;Mark F. van Delft;Ewa M. Michalak

  • Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

    Gemma L. Kelly;Stephanie Grabow;Stephanie Grabow;Stefan P. Glaser;Stefan P. Glaser;Leah Fitzsimmons

  • High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

    Erinna F. Lee;Jack D. Sadowsky;Brian J. Smith;Peter E. Czabotar

  • Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain.

    Melissa D. Boersma;Holly S. Haase;Kimberly J. Peterson-Kaufman;Erinna F. Lee

  • BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival.

    Erinna F Lee;Tiffany J Harris;Sharon Tran;Marco Evangelista

  • A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak

    Marc Kvansakul;Mark F. van Delft;Mark F. van Delft;Erinna F. Lee;Erinna F. Lee;Jacqueline M. Gulbis

Frequent Co-Authors

W. Douglas Fairlie
W. Douglas Fairlie La Trobe University
Peter M. Colman
Peter M. Colman Walter and Eliza Hall Institute of Medical Research
David C. S. Huang
David C. S. Huang Walter and Eliza Hall Institute of Medical Research
Brian J. Smith
Brian J. Smith QIMR Berghofer Medical Research Institute
Peter E. Czabotar
Peter E. Czabotar Walter and Eliza Hall Institute of Medical Research
Guillaume Lessene
Guillaume Lessene Walter and Eliza Hall Institute of Medical Research
Grant Dewson
Grant Dewson Walter and Eliza Hall Institute of Medical Research
Marco J. Herold
Marco J. Herold Walter and Eliza Hall Institute of Medical Research
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research
Philippe Bouillet
Philippe Bouillet Walter and Eliza Hall Institute of Medical Research

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