Eckhard R. Podack

Overview

Best Publications

• Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

  David Kägi;Birgit Ledermann;Kurt Bürki;Peter Seiler

  2639
  Citations

• Immunological mechanisms of the antitumor effects of supplemental oxygenation.

  Stephen M. Hatfield;Jorgen Kjaergaard;Dmitriy Lukashev;Taylor H. Schreiber

  597
  Citations

• Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

  Eckhard R. Podack;John Ding-E Young;Zanvil A. Cohn

  555
  Citations

• Structure and function of human perforin.

  Mathias G. Lichtenheld;Kristin J. Olsen;Ping Lu;David M. Lowrey

  461
  Citations

• Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.

  Eckhard R. Podack;Paula J. Konigsberg;Paula J. Konigsberg

  438
  Citations

• Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity

  John Ding E. Young;Hans Hengartner;Eckhard R. Podack;Zanvil A. Cohn

  435
  Citations

• The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.

  Matthew B. Baker;Norman H. Altman;Eckhard R. Podack;Robert B. Levy

  407
  Citations

• A central role of perforin in cytolysis

  Eckhard R. Podack;Hans Hengartner;Mathias G. Lichtenheld

  394
  Citations

• Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

  Sunil S Metkar;Baikun Wang;Miguel Aguilar-Santelises;Srikumar M Raja

  372
  Citations

• Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells

  Eckhard R. Podack;Gunther Dennert

  341
  Citations

• The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities.

  John Ding E. Young;Zanvil A. Cohn;Eckhard R. Podack

  331
  Citations

• Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway.

  Sylvie Isaaz;Kristin Baetz;Kristin Olsen;Eckhard Podack

  313
  Citations

• Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes.

  Gunther Dennert;Gunther Dennert;Eckhard R. Podack

  311
  Citations

• Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells.

  Richard K. Lee;Julie Spielman;Dong Yan Zhao;Kristin J. Olsen

  268
  Citations

• Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation

  Lei Fang;Becky Adkins;Vadim Deyev;Eckhard R. Podack

  265
  Citations

• The molecular mechanism of lymphocyte-mediated tumor cell lysis

  Eckhard R Podack

  249
  Citations

• Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid‐binding C2 domain

  Ruth Uellner;Marketa J. Zvelebil;Jean Hopkins;Jane Jones

  240
  Citations

• Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2

  Ge Deng;Eckhard R. Podack

  240
  Citations

• Apoptosis of Lung Cancer Cells Caused by Some Anti-cancer Agents (MMC, CPT-11, ADM) is Inhibited by BCL-2

  Tohru Ohmori;Eckhard R. Podack;Kazuto Nishio;Minako Takahashi

  237
  Citations

• Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

  Taylor H. Schreiber;Dietlinde Wolf;Matthew S. Tsai;Jackie Chirinos

  224
  Citations

• Isolation of human S-protein, an inhibitor of the membrane attack complex of complement.

  E R Podack;H J Muller-Eberhard

  224
  Citations

• Membrane attack by complement

  Eckhard R. Podack;Jurg Tschopp

  210
  Citations