Eckhard R. Podack mainly investigates Cell biology, Cytotoxic T cell, Perforin, Immunology and Cytolysis. His Cell biology research is multidisciplinary, relying on both Natural killer T cell, Cell membrane, CD28, Lymphocyte and Membrane glycoproteins. Eckhard R. Podack combines subjects such as T cell, Gene expression, Molecular biology and CD8 with his study of Cytotoxic T cell.
Eckhard R. Podack has included themes like Cellular immunity, Granzyme B and CTL* in his Perforin study. His Immunology research includes elements of Natural killer cell and Cancer research. His work carried out in the field of Cytolysis brings together such families of science as MACPF, Lymphokine-activated killer cell, Biophysics, Lysis and Membrane protein.
His primary areas of study are Immunology, Perforin, Cytotoxic T cell, Cell biology and Molecular biology. Immunology is represented through his CD8, Immune system, T cell, Antigen and Antibody research. Eckhard R. Podack has researched Perforin in several fields, including Fas ligand, Natural killer cell and Cytolysis.
His Cytotoxic T cell study incorporates themes from Apoptosis, Cancer research and Lymphocyte. The Cell biology study combines topics in areas such as Natural killer T cell, IL-2 receptor, CTL* and MACPF. Eckhard R. Podack works mostly in the field of Molecular biology, limiting it down to topics relating to Cytokine and, in certain cases, Tumor necrosis factor alpha.
The scientist’s investigation covers issues in Immunology, Perforin, Immune system, Cell biology and T cell. Eckhard R. Podack regularly ties together related areas like Cytotoxic T cell in his Immunology studies. His Cytotoxic T cell research is multidisciplinary, incorporating elements of Molecular biology and Antigen.
His biological study spans a wide range of topics, including Infectious disease, Gene expression, Microbiology and Bacteria. His Cell biology research integrates issues from Experimental autoimmune encephalomyelitis, Complement membrane attack complex and Cytolysis. The study incorporates disciplines such as Tumor microenvironment, Spleen, Cancer research and Lymphocyte in addition to T cell.
Eckhard R. Podack spends much of his time researching Immunology, Microbiology, Perforin, Cell biology and Immune system. His Immunology study integrates concerns from other disciplines, such as Cytotoxic T cell and Cancer research. His Microbiology research also works with subjects such as
His research in Perforin intersects with topics in Macrophage, RNA interference, Gene expression and Intracellular parasite. His Cell biology research incorporates themes from Complement membrane attack complex and FOXP3. His studies in Immune system integrate themes in fields like Candidate Gene Analysis, Bronchiectasis, Cystic fibrosis and Connective tissue, Pathology.
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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
David Kägi;Birgit Ledermann;Kurt Bürki;Peter Seiler.
Nature (1994)
Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules
Eckhard R. Podack;John Ding-E Young;Zanvil A. Cohn.
Proceedings of the National Academy of Sciences of the United States of America (1985)
Structure and function of human perforin.
Mathias G. Lichtenheld;Kristin J. Olsen;Ping Lu;David M. Lowrey.
Nature (1988)
Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity
John Ding E. Young;Hans Hengartner;Eckhard R. Podack;Zanvil A. Cohn.
Cell (1986)
Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.
Eckhard R. Podack;Paula J. Konigsberg;Paula J. Konigsberg.
Journal of Experimental Medicine (1984)
Immunological mechanisms of the antitumor effects of supplemental oxygenation.
Stephen M. Hatfield;Jorgen Kjaergaard;Dmitriy Lukashev;Taylor H. Schreiber.
Science Translational Medicine (2015)
The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.
Matthew B. Baker;Norman H. Altman;Eckhard R. Podack;Robert B. Levy.
Journal of Experimental Medicine (1996)
A central role of perforin in cytolysis
Eckhard R. Podack;Hans Hengartner;Mathias G. Lichtenheld.
Annual Review of Immunology (1991)
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation
Sunil S Metkar;Baikun Wang;Miguel Aguilar-Santelises;Srikumar M Raja.
Immunity (2002)
Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells
Eckhard R. Podack;Gunther Dennert.
Nature (1983)
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