John Ding-E Young spends much of his time researching Biochemistry, Molecular biology, Perforin, Cytolysis and Cytotoxic T cell. His study in Biochemistry is interdisciplinary in nature, drawing from both Calcifying Nanoparticles and Calcium. His Calcifying Nanoparticles study also includes
His studies deal with areas such as Interleukin 2, Interleukin 21, Lymphocyte and Metrial Gland as well as Perforin. His Cytolysis research is multidisciplinary, relying on both DNA fragmentation, Cell killing and Transmembrane protein. His Cytotoxic T cell study combines topics from a wide range of disciplines, such as Tumor necrosis factor alpha, Cell fractionation and Cytotoxicity.
John Ding-E Young mostly deals with Perforin, Biochemistry, Cytotoxic T cell, Molecular biology and Cell biology. His Pore forming protein study, which is part of a larger body of work in Perforin, is frequently linked to Cytolysin, bridging the gap between disciplines. His Biochemistry research includes themes of Biophysics and Calcifying Nanoparticles, Calcium.
His Calcium research incorporates themes from Nanoparticle and Calcification. His work carried out in the field of Cytotoxic T cell brings together such families of science as Immunology and Cytotoxicity. John Ding-E Young focuses mostly in the field of Molecular biology, narrowing it down to topics relating to Lymphokine-activated killer cell and, in certain cases, Natural killer T cell.
The scientist’s investigation covers issues in Gut flora, Immune system, Immunology, Nanoparticle and Autophagy. His work in the fields of Immunology, such as Proinflammatory cytokine, intersects with other areas such as Nontuberculous mycobacteria. He has included themes like Organic matter, Biochemistry, Mineral and Calcifying Nanoparticles in his Nanoparticle study.
The concepts of his Biochemistry study are interwoven with issues in Calcium and Metabolomics. His Autophagy research is multidisciplinary, incorporating perspectives in Mitochondrial biogenesis and Reactive oxygen species, Cell biology. His studies in Microbiology integrate themes in fields like Perforin, Cytotoxic T cell, NKG2D and Granulysin.
John Ding-E Young mainly investigates Gut flora, DNA repair, Reactive oxygen species, Obesity and Autophagy. His study looks at the relationship between Gut flora and fields such as Insulin resistance, as well as how they intersect with chemical problems. DNA repair is closely attributed to Cell biology in his study.
His work in Cell biology addresses issues such as Epithelium, which are connected to fields such as Inflammation. His study looks at the intersection of Reactive oxygen species and topics like Pharmacology with Antioxidant and Polyphenol. His research investigates the connection between Autophagy and topics such as Insulin that intersect with issues in Disease.
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Immune function in mice lacking the perforin gene.
Craig M. Walsh;Mehrdad Matloubian;Chau-Ching Liu;Roanne Ueda.
Proceedings of the National Academy of Sciences of the United States of America (1994)
Mechanism of membrane damage mediated by human eosinophil cationic protein.
John Ding-E Young;Christer G. B. Peterson;Per Venge;Zanvil A. Cohn.
Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity
John Ding E. Young;Hans Hengartner;Eckhard R. Podack;Zanvil A. Cohn.
Extracellular ATP as a trigger for apoptosis or programmed cell death.
Li Mou Zheng;Arturo Zychlinsky;Chau-Ching Liu;David M. Ojcius.
Journal of Cell Biology (1991)
Cell suicide in health and disease.
Richard C. Duke;David M. Ojcius;John Ding-E. Young.
Scientific American (1996)
The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities.
John Ding E. Young;Zanvil A. Cohn;Eckhard R. Podack.
Cytolytic pore-forming proteins and peptides: is there a common structural motif?
David M. Ojcius;John Ding E. Young.
Trends in Biochemical Sciences (1991)
Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes.
David M. Ojcius;Arturo Zychlinsky;Li Mou Zheng;John Ding-E Young.
Experimental Cell Research (1991)
Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor.
John Ding-E Young;Chau-Ching Liu;Gregory Butler;Zanvil A. Cohn.
Proceedings of the National Academy of Sciences of the United States of America (1987)
Isolation and characterization of a serine esterase from cytolytic T cell granules
John Ding-E Young;Lauren Gee Leong;Chau-Ching Liu;Angela Damiano.
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