World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
22204
World Ranking
4096
National Ranking
2013

Overview

Jonathan D. Ashwell is affiliated with the National Institutes of Health in the United States. Their research spans multiple fields with a strong emphasis on immunology, molecular biology, and medicine. Ashwell's work particularly focuses on the role of hormones, immune cell function, and signaling pathways in health and disease.

The scientist's main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology
  • Immunology and Microbiology

Within these broader disciplines, Ashwell has contributed extensively to several subfields:

  • Immunology
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Pharmacology

Ashwell's research touches on key topics such as:

  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Hormonal Regulation and Hypertension
  • Signaling Pathways in Disease
  • Adrenal Hormones and Disorders
  • Pharmacogenetics and Drug Metabolism
  • Cancer, Hypoxia, and Metabolism

Recent publications by Ashwell include the following papers:

  • Glucocorticoids in T cell development, differentiation and function, 2020, Nature reviews. Immunology
  • TNF plays a crucial role in inflammation by signaling via T cell TNFR2, 2021, Proceedings of the National Academy of Sciences
  • Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling, 2021, Journal of Clinical Investigation
  • Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth, 2023, Journal of Clinical Investigation
  • Effects of sex steroids on thymic epithelium and thymocyte development, 2022, Frontiers in Immunology

Ashwell frequently collaborates with other researchers. Notable co-authors include:

  • Matthew D. Taves
  • Shizuka Otsuka
  • Kaitlynn M. Donahue
  • Muhammad S. Alam
  • Matthias M. Gaida

The scientist has regularly published in several prominent scientific venues with multiple contributions, such as:

  • Journal of Clinical Investigation
  • The Journal of Immunology
  • Endocrinology
  • Nature reviews. Immunology
  • Proceedings of the National Academy of Sciences

Best Publications

  • Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.

    Yili Yang;Shengyun Fang;Jane P. Jensen;Allan M. Weissman

  • Glucocorticoids in T Cell Development and Function

    Jonathan D. Ashwell;Frank W. M. Lu;Melanie S. Vacchio

  • Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].

    Chuan-Jin Wu;Dietrich B Conze;Tao Li;Srinivasa M Srinivasula

  • Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

    Yue Shen;Maria Letizia Giardino Torchia;Gregory W. Lawson;Christopher L. Karp

  • Genomic instability in Gadd45a- deficient mice

    M. C. Hollander;M. S. Sheikh;D. V. Bulavin;K. Lundgren

  • IAPs: What's in a Name?

    Srinivasa M. Srinivasula;Jonathan D. Ashwell

  • TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

    Xiaoming Li;Yili Yang;Jonathan D. Ashwell

  • The many paths to p38 mitogen-activated protein kinase activation in the immune system

    Jonathan D. Ashwell

  • Failure to synthesize the T Cell CD3-ζ chain: Structure and function of a partial T cell receptor complex

    Jeffrey J. Sussman;Juan S. Bonifacino;Jennifer Lippincott-Schwartz;Allan M. Weissman

  • Steroid production in the thymus: implications for thymocyte selection.

    M S Vacchio;V Papadopoulos;J D Ashwell

  • Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.

    C M Zacharchuk;M Merćep;P K Chakraborti;S S Simons

  • Genetic and mutational analysis of the T-cell antigen receptor.

    Jonathan D. Ashwell;Richard D. Klausner

  • Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.

    M K Jenkins;J D Ashwell;R H Schwartz

  • Alternative p38 activation pathway mediated by T cell receptor–proximal tyrosine kinases

    Jesus M Salvador;Paul R Mittelstadt;Tad Guszczynski;Terry D Copeland

  • Inhibition of AP-1 by the Glucocorticoid-inducible Protein GILZ

    Paul R. Mittelstadt;Jonathan D. Ashwell

  • Cell growth cycle block of T cell hybridomas upon activation with antigen.

    J D Ashwell;R E Cunningham;P D Noguchi;D Hernandez

  • Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis.

    J M Lenczowski;L Dominguez;A M Eder;L B King

  • Optineurin Negatively Regulates TNFα- Induced NF-κB Activation by Competing with NEMO for Ubiquitinated RIP

    Guozhi Zhu;Chuan-Jin Wu;Yongge Zhao;Jonathan D. Ashwell

  • Structural Basis for Recognition of Diubiquitins by NEMO

    Yu Chih Lo;Su Chang Lin;Carla C. Rospigliosi;Dietrich B. Conze

  • Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-κB Activation

    Dietrich B. Conze;Chuan Jin Wu;James A. Thomas;Allison Landstrom

Frequent Co-Authors

Albert J. Fornace
Albert J. Fornace Georgetown University
Allan M. Weissman
Allan M. Weissman National Institutes of Health
Dragana Jankovic
Dragana Jankovic National Institute of Allergy and Infectious Diseases
Ettore Appella
Ettore Appella National Institutes of Health
Ronald H. Schwartz
Ronald H. Schwartz National Institutes of Health
Carl H. June
Carl H. June University of Pennsylvania
John J. O'Shea
John J. O'Shea National Institutes of Health
Ronald N. Germain
Ronald N. Germain National Institute of Allergy and Infectious Diseases
Juan S. Bonifacino
Juan S. Bonifacino National Institutes of Health

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