Mikko Hiltunen mainly investigates Genetics, Disease, Genome-wide association study, Alzheimer's disease and Pathology. Many of his studies involve connections with topics such as Apolipoprotein E and Genetics. His research in Apolipoprotein E intersects with topics in Odds ratio, Allele and Single-nucleotide polymorphism, Genetic association, Genotype.
His research in Genome-wide association study focuses on subjects like Case-control study, which are connected to Late onset, Molecular genetics and Human genetics. His work focuses on many connections between Alzheimer's disease and other disciplines, such as Dementia, that overlap with his field of interest in Amyloid, Brain biopsy, Biopsy and Lumbar. His biological study spans a wide range of topics, including SORL1 and Age of onset.
His primary areas of investigation include Internal medicine, Disease, Genetics, Endocrinology and Alzheimer's disease. His Internal medicine research incorporates themes from Oncology and Cardiology. His Disease study incorporates themes from Immunology, Pathogenesis, Bioinformatics, Neuroscience and Cohort.
His study in Genetics concentrates on Haplotype, Single-nucleotide polymorphism, Genotype, Allele and Gene. The study incorporates disciplines such as Odds ratio and Preeclampsia in addition to Genotype. His Alzheimer's disease research is multidisciplinary, incorporating elements of Genome-wide association study and Degenerative disease.
His scientific interests lie mostly in Internal medicine, Disease, Microglia, Cell biology and Normal pressure hydrocephalus. His studies in Internal medicine integrate themes in fields like Endocrinology and Cardiology. His studies deal with areas such as Stage, Computational biology and Gene as well as Disease.
His research on Gene concerns the broader Genetics. In general Microglia, his work in TREM2 is often linked to Wild type linking many areas of study. His Cell biology research includes elements of Autophagy, Cell, Cell type and Neuroinflammation.
His primary areas of study are Internal medicine, Disease, Cell biology, Gene and Microglia. In his study, Signal transduction is inextricably linked to Endocrinology, which falls within the broad field of Internal medicine. His Disease research is under the purview of Pathology.
His work deals with themes such as Long-term memory, Cell type and Tauopathy, which intersect with Cell biology. His Gene study integrates concerns from other disciplines, such as Bioinformatics and Amyloid. Mikko Hiltunen interconnects Astrocyte, Prodrug, Dementia, Genetic association and Genetic etiology in the investigation of issues within Microglia.
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj.
Nature Genetics (2013)
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish.
Nature Genetics (2011)
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi.
PLOS ONE (2014)
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez.
Nature Genetics (2017)
APOE and Alzheimer disease: a major gene with semi-dominant inheritance
E Genin;D Hannequin;D Wallon;K Sleegers.
Molecular Psychiatry (2011)
Lipoprotein-Associated Phospholipase A2, Platelet-Activating Factor Acetylhydrolase, Is Expressed by Macrophages in Human and Rabbit Atherosclerotic Lesions
Tomi Häkkinen;Jukka S. Luoma;Mikko O. Hiltunen;Colin H. Macphee.
Arteriosclerosis, Thrombosis, and Vascular Biology (1999)
Catheter-Mediated Vascular Endothelial Growth Factor Gene Transfer to Human Coronary Arteries after Angioplasty
Marja Laitinen;Juha Hartikainen;Mikko O. Hiltunen;Jaakko Eranen.
Human Gene Therapy (2000)
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype.
Antero Salminen;Johanna Ojala;Kai Kaarniranta;Annakaisa Haapasalo.
European Journal of Neuroscience (2011)
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
Stacy Steinberg;Hreinn Stefansson;Thorlakur Jonsson;Hrefna Johannsdottir.
Nature Genetics (2015)
DNA hypomethylation and methyltransferase expression in atherosclerotic lesions
Mikko O Hiltunen;Mikko P Turunen;Tomi P Häkkinen;Juha Rutanen.
Vascular Medicine (2002)
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