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Kathleen J. Sweadner

Kathleen J. Sweadner

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
13381
World Ranking
11919
National Ranking
5119

Research.com Recognitions

  • 1982 - Fellow of Alfred P. Sloan Foundation

Overview

Kathleen J. Sweadner is affiliated with Harvard University in the United States. Their research spans multiple fields, primarily focusing on biochemistry, genetics, and molecular biology, with notable contributions to medicine. The subfields of study connected with their work include molecular biology, neurology, surgery, cellular and molecular neuroscience, and cell biology.

Their research thematic areas cover a range of topics such as ion transport and channel regulation, ion channel regulation and function, neurological disorders and treatments, Parkinson's disease mechanisms and treatments, pancreatic function and diabetes, genetic neurodegenerative diseases, and endoplasmic reticulum stress and disease.

Kathleen J. Sweadner has contributed to several recent scientific papers, including:

  • Misfolding, altered membrane distributions, and the unfolded protein response contribute to pathogenicity differences in Na,K-ATPase ATP1A3 mutations (2020, Journal of Biological Chemistry)
  • In vivo prime editing rescues alternating hemiplegia of childhood in mice (2025, Cell)
  • Temperature instability of a mutation at a multidomain junction in Na,K-ATPase isoform ATP1A3 (p.Arg756His) produces a fever-induced neurological syndrome (2022, Journal of Biological Chemistry)
  • Na,K-ATPase Expression Can Be Limited Post-Transcriptionally: A Test of the Role of the Beta Subunit, and a Review of Evidence (2024, International Journal of Molecular Sciences)
  • The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodeling via redox and inflammatory mechanisms (2023, American Journal of Physiology-Heart and Circulatory Physiology)

Frequent coauthors in their work include Elena Arystarkhova, Laurie J. Ozelius, Allison Brashear, Ihtsham Haq, and Markus Terrey, reflecting ongoing collaborative efforts with established researchers.

Their publications appear regularly in venues such as the Journal of Biological Chemistry, Neurology Genetics, Neurology, Cell, and the International Journal of Molecular Sciences. Among these, the Journal of Biological Chemistry, Neurology Genetics, and Neurology are the most frequent publishing outlets.

In recognition of their contributions, Kathleen J. Sweadner was awarded the Fellow of Alfred P. Sloan Foundation honor in 1982.

Best Publications

  • Isozymes of the Na+/K+-ATPase.

    Kathleen J. Sweadner

  • Two molecular forms of (Na+ + K+)-stimulated ATPase in brain. Separation, and difference in affinity for strophanthidin.

    K J Sweadner

  • Mutations in the Na+/K+-ATPase α3 Gene ATP1A3 Are Associated with Rapid-Onset Dystonia Parkinsonism

    Patricia de Carvalho Aguiar;Patricia de Carvalho Aguiar;Kathleen J Sweadner;John T Penniston;Jacek Zaremba

  • Immunofluorescent localization of three Na,K-ATPase isozymes in the rat central nervous system : both neurons and glia can express more than one Na,K-ATPase

    Kevin M. McGrail;Joseph M. Phillips;Kathleen J. Sweadner

  • The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression.

    Kathleen J. Sweadner;Efren Rael;Efren Rael

  • The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase.

    S Gloor;H Antonicek;K J Sweadner;S Pagliusi

  • Identification of three isozyme proteins of the catalytic subunit of the Na,K-ATPase in rat brain.

    O Urayama;H Shutt;K J Sweadner

  • Active transport of sodium and potassium ions. Mechanism, function and regulation.

    Kathleen J. Sweadner;Stanley M. Goldin

  • The γ Subunit Modulates Na+ and K+Affinity of the Renal Na,K-ATPase *

    Elena Arystarkhova;Randall K. Wetzel;Natalya K. Asinovski;Kathleen J. Sweadner

  • Distinct neurological disorders with ATP1A3 mutations

    Erin L Heinzen;Alexis Arzimanoglou;Allison Brashear;Steven J Clapcote

  • Structural similarities of Na,K-ATPase and SERCA, the Ca(2+)-ATPase of the sarcoplasmic reticulum.

    Kathleen J. Sweadner;Claudia Donnet

  • The Na, K-ATPase α2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice

    Amy E. Moseley;Steve P. Lieske;Randall K. Wetzel;Paul F. James

  • Two isozymes of the Na,K-ATPase have distinct antigenic determinants.

    K J Sweadner;R C Gilkeson

  • Postnatal changes in Na,K-ATPase isoform expression in rat cardiac ventricle. Conservation of biphasic ouabain affinity.

    P A Lucchesi;K J Sweadner

  • Isoforms of Na,K-ATPase alpha and beta subunits in the rat cerebellum and in granule cell cultures.

    Liang Peng;Pablo Martin-Vasallo;Kathleen J. Sweadner

  • STRUCTURAL BASIS FOR SPECIES-SPECIFIC DIFFERENCES IN THE PHOSPHORYLATION OF NA,K-ATPASE BY PROTEIN KINASE C

    Marina S. Feschenko;Kathleen J. Sweadner

  • Enzymatic properties of separated isozymes of the Na,K-ATPase: substrate affinities, kinetic cooperativity, and ion transport stoichiometry

    K J Sweadner

  • Multiple tubulin forms are expressed by a single neurone.

    Illana Gozes;Kathleen J. Sweadner

  • Fine specificity mapping and topography of an isozyme-specific epitope of the Na,K-ATPase catalytic subunit.

    D P Felsenfeld;K J Sweadner

  • Filtration removal of endotoxin (pyrogens) in solution in different states of aggregation.

    K J Sweadner;M Forte;L L Nelsen

Frequent Co-Authors

Laurie J. Ozelius
Laurie J. Ozelius Harvard University
William B. Dobyns
William B. Dobyns University of Minnesota
Alan H. Beggs
Alan H. Beggs Harvard Medical School
John T. Penniston
John T. Penniston Harvard University
Larry R. Jones
Larry R. Jones Indiana University
Eva Andermann
Eva Andermann McGill University
William A. Gahl
William A. Gahl National Institutes of Health
Gerald M. Kidder
Gerald M. Kidder University of Western Ontario
Kamran Khodakhah
Kamran Khodakhah Albert Einstein College of Medicine
Frederick Andermann
Frederick Andermann McGill University

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